Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Timothy J, Aitman"'
Autor:
Tess D. Pottinger, Joshua E. Motelow, Gundula Povysil, Cristiane A. Martins Moreno, Zhong Ren, Hemali Phatnani, The New York Genome Center ALS Sequencing Consortium, Timothy J. Aitman, Javier Santoyo-Lopez, Scottish Genomes Partnership, Hiroshi Mitsumoto, ALS COSMOS Study Group, PLS COSMOS Study Group, GTAC Investigators, David B. Goldstein, Matthew B. Harms
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting over 300,000 people worldwide. It is characterized by the progressive decline of the nervous system that leads to the weakening of muscles which impacts
Externí odkaz:
https://doaj.org/article/77b804dfb5a346ffb655ea53c881d520
Autor:
Danny Laurent, Fiona Semple, Philip J. Starkey Lewis, Elaine Rose, Holly A. Black, Jennifer Coe, Stuart J. Forbes, Mark J. Arends, James W. Dear, Timothy J. Aitman
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-12 (2020)
Abstract Background Despite the emergence of cell-free DNA (cfDNA) as a clinical biomarker in cancer, the tissue origins of cfDNA in healthy individuals have to date been inferred only by indirect and relative measurement methods, such as tissue-spec
Externí odkaz:
https://doaj.org/article/9401d867436e46d280e980e296abdf7e
Autor:
Mihail Halachev, Alison Meynert, Martin S Taylor, Veronique Vitart, Shona M Kerr, Lucija Klaric, S. G. P. Consortium, Timothy J Aitman, Chris S Haley, James G Prendergast, Carys Pugh, David A Hume, Sarah E Harris, David C Liewald, Ian J Deary, Colin A Semple, James F Wilson
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008480 (2019)
Human population isolates provide a snapshot of the impact of historical demographic processes on population genetics. Such data facilitate studies of the functional impact of rare sequence variants on biomedical phenotypes, as strong genetic drift c
Externí odkaz:
https://doaj.org/article/09ea862e75084e98bfa75eb5fa8e4a38
Autor:
Antoni Olona, Ximena Terra, Jeong-Hun Ko, Carme Grau-Bové, Montserrat Pinent, Anna Ardevol, Ana Garcia Diaz, Aida Moreno-Moral, Matthew Edin, David Bishop-Bailey, Darryl C. Zeldin, Timothy J. Aitman, Enrico Petretto, Mayte Blay, Jacques Behmoaras
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 18-32 (2018)
Objective: When molecular drivers of healthy adipogenesis are perturbed, this can cause hepatic steatosis. The role of arachidonic acid (AA) and its downstream enzymatic cascades, such as cyclooxygenase, in adipogenesis is well established. The exact
Externí odkaz:
https://doaj.org/article/d7285575e91349bf8008e12a518b25d1
Autor:
Bhuvaneish T. Selvaraj, Matthew R. Livesey, Chen Zhao, Jenna M. Gregory, Owain T. James, Elaine M. Cleary, Amit K. Chouhan, Angus B. Gane, Emma M. Perkins, Owen Dando, Simon G. Lillico, Youn-Bok Lee, Agnes L. Nishimura, Urjana Poreci, Sai Thankamony, Meryll Pray, Navneet A. Vasistha, Dario Magnani, Shyamanga Borooah, Karen Burr, David Story, Alexander McCampbell, Christopher E. Shaw, Peter C. Kind, Timothy J. Aitman, C. Bruce A. Whitelaw, Ian Wilmut, Colin Smith, Gareth B. Miles, Giles E. Hardingham, David J. A. Wyllie, Siddharthan Chandran
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Repeat expansion mutation in C9ORF72 is the most common cause of familial ALS. Here, the authors generate motor neurons from cells of patients with C9ORF72 mutations, and characterize changes in gene expression in these motor neurons compared to gene
Externí odkaz:
https://doaj.org/article/6a962a5b03a74471945829a86138ad2f
Autor:
Peter J. Arthur-Farraj, Claire C. Morgan, Martyna Adamowicz, Jose A. Gomez-Sanchez, Shaline V. Fazal, Anthony Beucher, Bonnie Razzaghi, Rhona Mirsky, Kristjan R. Jessen, Timothy J. Aitman
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2719-2734 (2017)
Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly understood. Here, we perform a combined whole-genome, coding and non-coding RNA and CpG methy
Externí odkaz:
https://doaj.org/article/b1df5bc580954457aa1f44a8b2ac5ad5
Autor:
Philip M. Coan, Oliver Hummel, Ana Garcia Diaz, Marjorie Barrier, Neza Alfazema, Penny J. Norsworthy, Michal Pravenec, Enrico Petretto, Norbert Hübner, Timothy J. Aitman
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 3, Pp 297-306 (2017)
We previously mapped hypertension-related insulin resistance quantitative trait loci (QTLs) to rat chromosomes 4, 12 and 16 using adipocytes from F2 crosses between spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats, and subsequently identi
Externí odkaz:
https://doaj.org/article/217f43e21ad843a2903c54aea3fe26e6
Autor:
Sophie J. Warlow, Martyna Adamowicz, John P. Thomson, Robert A. Wescott, Christelle Robert, Lara M. Carey, Helen Thain, Kate Cuschieri, Lucy Q. Li, Brendan Conn, Ashley Hay, Iain J. Nixon, Timothy J. Aitman
Publikováno v:
Warlow, S J, Adamowicz, M, Thomson, J P, Wescott, R A, Robert, C, Carey, L M, Thain, H, Cuschieri, K, Li, L Q, Conn, B, Hay, A, Nixon, I J & Aitman, T J 2022, ' Longitudinal measurement of HPV copy number in cell-free DNA is associated with patient outcomes in HPV-positive oropharyngeal cancer ', EJSO-European Journal of Surgical Oncology, vol. 48, no. 6, pp. 1224-1234 . https://doi.org/10.1016/j.ejso.2022.03.232
INTRODUCTION: Oropharyngeal squamous cell carcinoma (OPSCC) is increasing in global prevalence and is divided into two types dependent on association with human papillomavirus (HPV). Assay of HPV copy number in plasma cell-free DNA (cfDNA) provides a
Autor:
Danielle J, Leighton, Morad, Ansari, Judith, Newton, David, Parry, Elaine, Cleary, Shuna, Colville, Laura, Stephenson, Juan, Larraz, Micheala, Johnson, Emily, Beswick, Michael, Wong, Jenna, Gregory, Javier, Carod Artal, Richard, Davenport, Callum, Duncan, Ian, Morrison, Colin, Smith, Robert, Swingler, Ian J, Deary, Mary, Porteous, Timothy J, Aitman, Siddharthan, Chandran, George H, Gorrie, Suvankar, Pal, Carolyn, Webber
Publikováno v:
Journal of neurology.
We investigated the phenotypes and genotypes of a cohort of 'long-surviving' individuals with motor neuron disease (MND) to identify potential targets for prognostication.Patients were recruited via the Clinical Audit Research and Evaluation for MND
Autor:
Lucy Q. Li, Martyna Adamowicz, Robert A. Wescott, Sophie J. Warlow, John P. Thomson, Christelle Robert, Lara M. Carey, Helen Thain, Kate Cuschieri, Brendan Conn, Ashley Hay, Timothy J. Aitman, Iain J. Nixon
Publikováno v:
Qian Li, L, Adamowicz, M, Wescott, R, Warlow, S, Thomson, J, Robert, C, Carey, L, Thain, H, Cuschieri, K S, Conn, B, Hay, A, Aitman, T J & Nixon, I 2022, ' The role of liquid biopsy in management of the neck with indeterminate response on post-treatment imaging following non-surgical management of oropharyngeal cancer ', European Journal of Surgical Oncology (EJSO) . https://doi.org/10.1016/j.ejso.2022.09.016
This study aimed to determine if post-treatment HPV cell-free DNA (cfDNA) can assist in the decision-making process for salvage neck dissection in patients following non-surgical treatment of oropharyngeal squamous cell carcinoma (OPSCC) with a parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14cfc54dcec878ba6b4c944842c7d43
https://hdl.handle.net/20.500.11820/1be71c00-77cd-4031-9a12-c97e359d258d
https://hdl.handle.net/20.500.11820/1be71c00-77cd-4031-9a12-c97e359d258d