Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Timothy Ikeda"'
Autor:
Bharath Srinivasan, Juan Daniel Flórez Weidinger, Xiang Zhai, Guillaume Lemercier, Timothy Ikeda, Mark Brewer, Bairu Zhang, Stephan Heyse, Jonathan Wingfield, Stephan Steigele
Publikováno v:
SLAS Discovery, Vol 27, Iss 8, Pp 460-470 (2022)
Recent efforts for increasing the success in drug discovery focus on an early, massive, and routine mechanistic and/or kinetic characterization of drug-target engagement as part of a design-make-test-analyze strategy. From an experimental perspective
Externí odkaz:
https://doaj.org/article/a2126a1a1f8f429598c4f15e9ed9a831
Autor:
Huimin Wang, Tony Johnson, Sameer Kawatkar, Peng Wang, Lakshmaiah Gingipalli, Scott D. Edmondson, Jon Read, Scott Boyd, Timothy Ikeda, Andrew Pike, Qibin Su, Olivier Lorthioir, Lianghe Wang, Hannah Dry, Hannah Pollard, Barlaam Bernard Christophe, Haiyun Wang, Scott Boiko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127523
Hybridisation of amino-pyrimidine based SYK inhibitors (e.g. 1a) with previously reported diamine-based SYK inhibitors (e.g. TAK-659) led to the identification and optimisation of a novel pyrimidine-based series of potent and selective SYK inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64b2339e860fa1c384ebed0af403608
https://doi.org/10.1016/j.bmcl.2020.127523
https://doi.org/10.1016/j.bmcl.2020.127523
Autor:
James E. Dowling, Scott G. Lamont, Quanshan Wen, Scott Boiko, Peng Wang, Sameer Kawatkar, Scott D. Edmondson, Haiyun Wang, Ujjal Sarkar, Zhiyuan Yan, Barlaam Bernard Christophe, Andrew Pike, Joe Patel, Jon Read, Iain Simpson, Paul D. Kemmitt, Hannah Pollard, Hannah Dry, Timothy Ikeda, Qibin Su, David W. Watson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127393
Spleen Tyrosine Kinase (SYK) is a well-studied enzyme with therapeutic applications in oncology and autoimmune diseases. We identified an azabenzimidazole (ABI) series of SYK inhibitors by mining activity data of 86,000 compounds from legacy biochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1114c3d707cb69b964dd0155b8dfbd45
https://doi.org/10.1016/j.bmcl.2020.127393
https://doi.org/10.1016/j.bmcl.2020.127393