Zobrazeno 1 - 10 of 98 pro vyhledávání: '"Timothy I Shaw"'
1
Akademický článek
An Epigenomic fingerprint of human cancers by landscape interrogation of super enhancers at the constituent level.
Autor: Xiang Liu, Nancy Gillis, Chang Jiang, Anthony McCofie, Timothy I Shaw, Aik-Choon Tan, Bo Zhao, Lixin Wan, Derek R Duckett, Mingxiang Teng
Publikováno v: PLoS Computational Biology, Vol 20, Iss 2, p e1011873 (2024)
Super enhancers (SE), large genomic elements that activate transcription and drive cell identity, have been found with cancer-specific gene regulation in human cancers. Recent studies reported the importance of understanding the cooperation and funct
Externí odkaz: https://doaj.org/article/7df234ab18304bf99d2f0bbcc8d2190f
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6
Akademický článek
Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.
Autor: Samit Ganguly, David Finkelstein, Timothy I Shaw, Ryan D Michalek, Kimberly M Zorn, Sean Ekins, Kazuto Yasuda, Yu Fukuda, John D Schuetz, Kamalika Mukherjee, Erin G Schuetz
Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0253852 (2021)
Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and hepatic drug clearance. The systemic impact of Bcrp and Pgp ablation on metabolic homeosta
Externí odkaz: https://doaj.org/article/b18f9e558107487fa2603259aa77bcbd
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7
Akademický článek
Transcriptome sequencing and annotation for the Jamaican fruit bat (Artibeus jamaicensis).
Autor: Timothy I Shaw, Anuj Srivastava, Wen-Chi Chou, Liang Liu, Ann Hawkinson, Travis C Glenn, Rick Adams, Tony Schountz
Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48472 (2012)
The Jamaican fruit bat (Artibeus jamaicensis) is one of the most common bats in the tropical Americas. It is thought to be a potential reservoir host of Tacaribe virus, an arenavirus closely related to the South American hemorrhagic fever viruses. We
Externí odkaz: https://doaj.org/article/5edf6f15e0e549a2b673970d6cede6d3
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8
Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia
Autor: Jason E. Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda Ries, Tiffany Hylkema, Era L. Pogosova-Agadjanyan, Sneha Challa, Amanda Leonti, Timothy I. Shaw, Timothy J. Triche, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Xiaotu Ma, Derek L. Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Publikováno v: Journal of Clinical Oncology. 41:2949-2962
PURPOSE Optimized strategies for risk classification are essential to tailor therapy for patients with biologically distinctive disease. Risk classification in pediatric acute myeloid leukemia (pAML) relies on detection of translocations and gene mut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76ef473648313347225baef9d1b228a4
https://doi.org/10.1200/jco.22.01114
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9
Akademický článek
A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice
Autor: Liam C. Hunt, Jared Stover, Benard Haugen, Timothy I. Shaw, Yuxin Li, Vishwajeeth R. Pagala, David Finkelstein, Elisabeth R. Barton, Yiping Fan, Myriam Labelle, Junmin Peng, Fabio Demontis
Publikováno v: Cell Reports, Vol 28, Iss 5, Pp 1268-1281.e6 (2019)
Summary: Skeletal muscle cell (myofiber) atrophy is a detrimental component of aging and cancer that primarily results from muscle protein degradation via the proteasome and ubiquitin ligases. Transcriptional upregulation of some ubiquitin ligases co
Externí odkaz: https://doaj.org/article/dcb1de6fa47e484ca274395c83a6afde
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