Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Timothy I Richardson"'
Autor:
Vera Ruíz Moleón, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Timothy I. Richardson, Maryam Fotouhi, Charles Alende, Logan M. Bedford
Publikováno v:
F1000Research, Vol 13 (2024)
Phosphatidylinositol-specific phospholipase C gamma 2 (PLC-gamma-2) is an enzyme that regulates the function of immune cells. PLC-gamma-2 has been implicated in neurodegenerative and autoimmune disorders, yet investigation of this protein has been li
Externí odkaz:
https://doaj.org/article/0d08fa12e4e4431487c4dbc896ef7605
Autor:
Cynthia D. Jesudason, Emily R. Mason, Shaoyou Chu, Adrian L. Oblak, June Javens‐Wolfe, Mustapha Moussaif, Greg Durst, Philip Hipskind, Daniel E. Beck, Jiajun Dong, Ovini Amarasinghe, Zhong‐Yin Zhang, Adam K. Hamdani, Kratika Singhal, Andrew D. Mesecar, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Disha M. Soni, Murugesh Kandasamy, Andrea R. Masters, Sara K Quinney, Suzanne Doolen, Hasi Huhe, Stacey J. Sukoff Rizzo, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract INTRODUCTION The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate‐5‐phosphatase (INPP5D), which encodes Src homology 2 (SH2) domain–containing inositol polyphosphat
Externí odkaz:
https://doaj.org/article/4d6f6a10135b4cdbb5e5fc4dd51947a7
Autor:
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce Jr., Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction A chemogenomic set of small molecules with annotated activities and implicated roles in Alzheimer's disease (AD) called the AD Informer Set was recently developed and made available to the AD research community: https://treatad.
Externí odkaz:
https://doaj.org/article/b33c64d9d5fa4d89ad4554a76c6b0930
Autor:
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce, Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the Accelerating Medicines Partnership Program for Alzheimer's Disease (AMP AD) program. Methods Publicly available resources, such as literat
Externí odkaz:
https://doaj.org/article/e2d6a7a95cd548b0ab470f7102528da7
Autor:
Timothy I Richardson, Cynthia D Jesudason, Karen L Lobb, Gregory L Durst, Brent Clayton, Steven M Massey, Daniel E Beck, Zhong‐Yin Zhang, Jiajun Dong, Jianping Lin, Jinmin Miao, Karson S Putt, Andrew D Mesecar, Adam K Hamdani, Emma K Lendy, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Shaoyou Chu, Emily R Mason, Adrian L Oblak, Disha Soni, Sara K Quinney, Larissa L Silva, Murugesh Kandasamy, Andrea R Masters, Stacey J Sukoff Rizzo, Suzanne Doolen, Kun Huang, Jie Zhang, Bruce T Lamb, Alan D Palkowitz
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78be85314990ac6063212d386aa1803
https://doi.org/10.1002/alz.068781
https://doi.org/10.1002/alz.068781
Autor:
Charles W, Lugar, Christian A, Clarke, Richard, Morphy, Helene, Rudyk, Selma, Sapmaz, Ryan E, Stites, Grant M, Vaught, Kelly, Furness, Howard B, Broughton, Greg L, Durst, David K, Clawson, Stephanie L, Stout, Sherry Y, Guo, Jim D, Durbin, Keith R, Stayrook, Denise D, Edmondson, Kristy, Kikly, Nicole E, New, Holly A, Bina, Mark G, Chambers, Pamela, Shetler, William Y, Chang, Veavi Ching-Yun, Chang, Rob, Barr, Wendy H, Gough, Jimmy P, Steele, Brian, Getman, Nita, Patel, Brian M, Mathes, Timothy I, Richardson
Publikováno v:
Journal of medicinal chemistry. 64(9)
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef03d39fb502b855beadc34c7a19e1e7
https://pubmed.ncbi.nlm.nih.gov/33852312
https://pubmed.ncbi.nlm.nih.gov/33852312
Autor:
Hannah Nguyen, Xing Jun Cao, Lisa Hong Chen, Robert M. Campbell, Jonathan B. Olsen, Timothy I. Richardson, Alexander Horvath, Bomie Han, Benjamin A. Garcia
The significance of non-histone lysine methylation in cell biology and human disease is an emerging area of research exploration. The development of small molecule inhibitors that selectively and potently target enzymes that catalyze the addition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c76497e2c7055f5ac4b29b761d1523
https://europepmc.org/articles/PMC4813708/
https://europepmc.org/articles/PMC4813708/
Publikováno v:
Tetrahedron. 55:8977-8996
Filipin III ( 1 ), a polyene macrolide antibiotic, has been synthesized for the first time. The polyol chain was assembled using a stereoselective carbon-carbon bond forming strategy previously developed in our lab: a cyanohydrin acetonide alkylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c7836c4a29a6d8e34ca14a7ea6853e
https://doi.org/10.1016/s0040-4020(99)00457-3
https://doi.org/10.1016/s0040-4020(99)00457-3
Autor:
Michael R. Wood, B. Wesley Trotter, Christopher J. Dinsmore, Jeffrey L. Katz, Timothy I. Richardson, David A. Evans, Paul S. Watson
Publikováno v:
Angewandte Chemie International Edition. 37:2704-2708
Controlling the elements of planar and axial chirality are the principal challenges in the synthesis of the aglycon of vancomycin. Vancomycin is the prototypical member of the glycopeptide family of antibiotics which are effective for the treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0db903cb63546f2dd4b324bd29a37133
https://doi.org/10.1002/(sici)1521-3773(19981016)37:19<2704::aid-anie2704>3.0.co
https://doi.org/10.1002/(sici)1521-3773(19981016)37:19<2704::aid-anie2704>3.0.co
Autor:
Timothy I. Richardson, Michael R. Wood, B. Wesley Trotter, Jeffrey L. Katz, David A. Evans, James C. Barrow
Publikováno v:
Angewandte Chemie International Edition. 37:2700-2704
Controlling the elements of planar and axial chirality are the principal challenges in the synthesis of the aglycon of vancomycin. Vancomycin is the prototypical member of the glycopeptide family of antibiotics which are effective for the treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79c9c144f2e00959ef27f363cba2ff6
https://doi.org/10.1002/(sici)1521-3773(19981016)37:19<2700::aid-anie2700>3.0.co
https://doi.org/10.1002/(sici)1521-3773(19981016)37:19<2700::aid-anie2700>3.0.co