Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Timothy Hoggard"'
Publikováno v:
PLoS Genetics, Vol 20, Iss 8, p e1011366 (2024)
In Saccharomyces cerevisiae, the forkhead (Fkh) transcription factor Fkh1 (forkhead homolog) enhances the activity of many DNA replication origins that act in early S-phase (early origins). Current models posit that Fkh1 acts directly to promote thes
Externí odkaz:
https://doaj.org/article/2360b81529ef4b71ad7488bf4d73cdf6
Autor:
Timothy Hoggard, Ivan Liachko, Cassaundra Burt, Troy Meikle, Katherine Jiang, Gheorghe Craciun, Maitreya J. Dunham, Catherine A. Fox
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 4, Pp 993-1012 (2016)
The ability of plasmids to propagate in Saccharomyces cerevisiae has been instrumental in defining eukaryotic chromosomal control elements. Stable propagation demands both plasmid replication, which requires a chromosomal replication origin (i.e., an
Externí odkaz:
https://doaj.org/article/cb3bd1dbcd2b4d0c855051d7676cd891
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003798 (2013)
Eukaryotic DNA replication origins are selected in G1-phase when the origin recognition complex (ORC) binds chromosomal positions and triggers molecular events culminating in the initiation of DNA replication (a.k.a. origin firing) during S-phase. Ea
Externí odkaz:
https://doaj.org/article/d39805776d0644a199ad3b44d503d8ad
Publikováno v:
Nucleic Acids Research
The pioneer event in eukaryotic DNA replication is binding of chromosomal DNA by the origin recognitioncomplex (ORC). The ORC-DNA complex directs the formation of origins, the specific chromosomal regions where DNA synthesis initiates. In all eukaryo
Autor:
Gemma Regan-Mochrie, Timothy Hoggard, Nikhil Bhagwat, Gerard Lynch, Neil Hunter, Dirk Remus, Catherine A. Fox, Xiaolan Zhao
Publikováno v:
Genes & development, vol 36, iss 13-14
Sumoylation is emerging as a posttranslation modification important for regulating chromosome duplication and stability. The origin recognition complex (ORC) that directs DNA replication initiation by loading the MCM replicative helicase onto origins
The pioneer event in eukaryotic DNA replication is binding of chromosomal DNA by the origin recognition complex (ORC), which directs the formation of origins, the specific chromosomal regions where DNA will be unwound for the initiation of DNA synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad3827649e4c233aa6880c85b1d6c54c
https://doi.org/10.1101/2021.03.01.433423
https://doi.org/10.1101/2021.03.01.433423
Autor:
Timothy Hoggard, Catherine A. Fox, Conrad A. Nieduszynski, Michael Weinreich, Carolin A. Müller
Publikováno v:
Proc Natl Acad Sci U S A
A eukaryotic chromosome relies on the function of multiple spatially distributed DNA replication origins for its stable inheritance. The location of an origin is determined by the chromosomal position of an MCM complex, the inactive form of the DNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a71fccc451b5232cff6ee04d923302
Autor:
Michael J. Beebe, Thomas R Sellers, Timothy Hoggard, Gregory Carlson, Jordan Meiss, D. W. Watson, Roy W. Sanders, Jonathan H Quade, Hassan R. Mir, Rafael Serrano, Darryl A. Auston, Brian J. Kistler, Anjan R. Shah, Robert Bruce Simpson
Publikováno v:
Journal of Orthopaedic Trauma. 31:215-219
Objective To compare the incidence of complications (wound, infection, and nonunion) among those patients treated with closed, percutaneous, and open intramedullary nailing for closed tibial shaft fractures. Design Retrospective review. Setting Multi
Autor:
Ivan Liachko, Katherine Jiang, Cassaundra Burt, Troy Meikle, Catherine A. Fox, Gheorghe Craciun, Maitreya J. Dunham, Timothy Hoggard
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 6, Iss 4, Pp 993-1012 (2016)
G3: Genes, Genomes, Genetics, Vol 6, Iss 4, Pp 993-1012 (2016)
The ability of plasmids to propagate in Saccharomyces cerevisiae has been instrumental in defining eukaryotic chromosomal control elements. Stable propagation demands both plasmid replication, which requires a chromosomal replication origin (i.e., an
Autor:
Sandya Subramanian, Erika Shor, Timothy Hoggard, Michael Weinreich, Edel M. Hyland, Fu-Jung Chang, Jessica Kenworthy, Catherine A. Fox, Jef D. Boeke, Julie Chueng, Kelsey Rae Perry
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007418 (2018)
Hoggard, T A, Chang, F, Perry, K R, Subramanian, S, Kenworthy, J, Chueng, J, Shor, E, Hyland, E M, Boeke, J D, Weinreich, M & Fox, C A 2018, ' Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins ', PLoS Genetics, vol. 14, no. 5, pp. e1007418 . https://doi.org/10.1371/journal.pgen.1007418
PLoS Genetics
Hoggard, T A, Chang, F, Perry, K R, Subramanian, S, Kenworthy, J, Chueng, J, Shor, E, Hyland, E M, Boeke, J D, Weinreich, M & Fox, C A 2018, ' Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins ', PLoS Genetics, vol. 14, no. 5, pp. e1007418 . https://doi.org/10.1371/journal.pgen.1007418
PLoS Genetics
Most active DNA replication origins are found within euchromatin, while origins within heterochromatin are often inactive or inhibited. In yeast, origin activity within heterochromatin is negatively controlled by the histone H4K16 deacetylase, Sir2,