Zobrazeno 1 - 10
of 339
pro vyhledávání: '"Timothy Hla"'
Autor:
Colin Niaudet, Bongnam Jung, Andrew Kuo, Steven Swendeman, Edward Bull, Takahiro Seno, Reed Crocker, Zhongjie Fu, Lois E H Smith, Timothy Hla
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 5, Pp 1-9 (2023)
Abstract Sphingosine‐1‐phosphate (S1P), the circulating HDL‐bound lipid mediator that acts via S1P receptors (S1PR), is required for normal vascular development. The role of this signaling axis in vascular retinopathies is unclear. Here, we sho
Externí odkaz:
https://doaj.org/article/baf615af7db14d7584f85d219c23d926
Autor:
Timothy Hla
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/6c229af4c5f24a268e0214a1fd7574aa
Autor:
Andrew Kuo, Antonio Checa, Colin Niaudet, Bongnam Jung, Zhongjie Fu, Craig E Wheelock, Sasha A Singh, Masanori Aikawa, Lois E Smith, Richard L Proia, Timothy Hla
Publikováno v:
eLife, Vol 11 (2022)
Serine palmitoyl transferase (SPT), the rate-limiting enzyme in the de novo synthesis of sphingolipids (SL), is needed for embryonic development, physiological homeostasis, and response to stress. The functions of de novo SL synthesis in vascular end
Externí odkaz:
https://doaj.org/article/e21f8001eecc472486c15e1a9e2ebd82
Autor:
Hideru Obinata, Andrew Kuo, Yukata Wada, Steven Swendeman, Catherine H. Liu, Victoria A. Blaho, Rieko Nagumo, Kenichi Satoh, Takashi Izumi, Timothy Hla
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1912-1921 (2019)
HDL-bound ApoM and albumin are protein chaperones for the circulating bioactive lipid, sphingosine 1-phosphate (S1P); in this role, they support essential extracellular S1P signaling functions in the vascular and immune systems. We previously showed
Externí odkaz:
https://doaj.org/article/11029506ce7d401da3576e4631334a6c
Autor:
Eric Engelbrecht, Michel V Levesque, Liqun He, Michael Vanlandewijck, Anja Nitzsche, Hira Niazi, Andrew Kuo, Sasha A Singh, Masanori Aikawa, Kristina Holton, Richard L Proia, Mari Kono, William T Pu, Eric Camerer, Christer Betsholtz, Timothy Hla
Publikováno v:
eLife, Vol 9 (2020)
Despite the medical importance of G protein-coupled receptors (GPCRs), in vivo cellular heterogeneity of GPCR signaling and downstream transcriptional responses are not understood. We report the comprehensive characterization of transcriptomes (bulk
Externí odkaz:
https://doaj.org/article/2b95d8d5a479422885261efe96819fc7
Autor:
Rajesh K. Singh, Abigail S. Haka, Alexandria Brumfield, Inna Grosheva, Priya Bhardwaj, Harvey F. Chin, Yuquan Xiong, Timothy Hla, Frederick R. Maxfield
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 10, Pp 1977-1987 (2017)
Macrophages use an extracellular, hydrolytic compartment formed by local actin polymerization to digest aggregated LDL (agLDL). Catabolism of agLDL promotes foam cell formation and creates an environment rich in LDL catabolites, including cholesterol
Externí odkaz:
https://doaj.org/article/e5661c0565b844518f2996af0079d911
Autor:
Mari Kono, Elizabeth G. Conlon, Samantha Y. Lux, Keisuke Yanagida, Timothy Hla, Richard L. Proia
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
G protein-coupled receptors are involved in numerous physiological functions, thus, they represent potential pharmaceutical targets. Here Kono et al. describe a new mouse model to image GPCR activation in real-time by exploiting firefly split lucifer
Externí odkaz:
https://doaj.org/article/c32511cc563843f48d30e2af1c4c9730
Autor:
Yi Ban, Wenjuan Dong, Lixing Zhang, Tian Zhou, Ahmad S. Altiti, Khaleel Ali, David R. Mootoo, Victoria A. Blaho, Timothy Hla, Yi Ren, Xiaojing Ma
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer). Its α-anomer (α-Galcer) has b
Externí odkaz:
https://doaj.org/article/5251299b5032476da7c45a6000463557
Autor:
Takuya Inoue, Masataka Kohno, Hidetake Nagahara, Ken Murakami, Tomoya Sagawa, Akiko Kasahara, Shunya Kaneshita, Takashi Kida, Kazuki Fujioka, Makoto Wada, Hiroshi Nakada, Timothy Hla, Yutaka Kawahito
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218090 (2019)
BackgroundSphingosine-1-phosphate receptor 3 (S1P3) is one of five receptors for sphingosine-1-phosphate (S1P). S1P/S1P3 signaling is involved in numerous physiological and pathological processes including bone metabolism, sepsis, cancer, and immunit
Externí odkaz:
https://doaj.org/article/3109b0cb113843a7b02134e79180a4d6
Autor:
Mallika Ghosh, Shobha Thangada, Oisharya Dasgupta, Kamal M Khanna, Harold T Yamase, Michael Kashgarian, Timothy Hla, Linda H Shapiro, Fernando A Ferrer
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194053 (2018)
Sphingosine Kinase-2 (Sphk2) is responsible for the production of the bioactive lipid Sphingosine-1 Phosphate, a key regulator of tissue repair. Here we address the in vivo significance of Sphingosine Kinase -2 in renal inflammation/fibrosis in respo
Externí odkaz:
https://doaj.org/article/42d52938e5744f6c81a303150b339e7f