Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Timothy Hardman"'
Autor:
Marc D. Ryser, Diego Mallo, Allison Hall, Timothy Hardman, Lorraine M. King, Sergei Tatishchev, Inmaculada C. Sorribes, Carlo C. Maley, Jeffrey R. Marks, E. Shelley Hwang, Darryl Shibata
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Invasion is a critical step in tumor development. Here, in colorectal cancer, the authors show that multiclonal invasion of the muscularis mucosae is pervasive, suggesting that invasive capacity is not a significant bottleneck in the evolution of the
Externí odkaz:
https://doaj.org/article/0d25956044414a47b376fdedd27dfad9
Autor:
Daniela Siel, María José Ubilla, Sonia Vidal, Alexandra Loaiza, John Quiroga, Federico Cifuentes, Timothy Hardman, Lisette Lapierre, Rodolfo Paredes, Leonardo Sáenz
Publikováno v:
Animals, Vol 10, Iss 2, p 226 (2020)
Canine immunocastration development has been of interest for many years as a complementary strategy to surgical castration. The purpose of this paper was to verify the effect of a recombinant vaccine for dog immunocastration. Two tests were done, one
Externí odkaz:
https://doaj.org/article/1782259daf7247508d0ab232bf201ab0
Publikováno v:
Medical Writing. 31:10-23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8606d05a8f5f3175e52597c6ed9c43c
https://doi.org/10.56012/ejbj4872
https://doi.org/10.56012/ejbj4872
Autor:
Siri H Strand, Belén Rivero-Gutiérrez, Kathleen E Houlahan, Jose A Seoane, Lorraine M King, Tyler Risom, Lunden Simpson, Sujay Vennam, Aziz Khan, Timothy Hardman, Bryan E Harmon, Fergus J Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla F McAuliffe, Julie Nangia, Joanna Lee, Jennifer Tseng, Anna Maria Storniolo, Alastair Thompson, Gaorav Gupta, Robyn Burns, Deborah J Veis, Katherine DeSchryver, Chunfang Zhu, Magdalena Matusiak, Jason Wang, Shirley X Zhu, Jen Tappenden, Daisy Yi Ding, Dadong Zhang, Jingqin Luo, Shu Jiang, Sushama Varma, Cody Straub, Sucheta Srivastava, Christina Curtis, Rob Tibshirani, Robert Michael Angelo, Allison Hall, Kouros Owzar, Kornelia Polyak, Carlo Maley, Jeffrey R Marks, Graham A Colditz, E Shelley Hwang, Robert B West
Publikováno v:
Cancer Research. 82:GS4-07
Background. DCIS consists of a molecularly heterogeneous group of premalignant lesions, with variable risk of invasive progression. Understanding biomarkers for invasive progression could help individualize treatment recommendations based upon tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f8c97e776b4367db99f41dc29040b6b
https://doi.org/10.1158/1538-7445.sabcs21-gs4-07
https://doi.org/10.1158/1538-7445.sabcs21-gs4-07
Autor:
Siri H. Strand, Belén Rivero-Gutiérrez, Kathleen E. Houlahan, Jose A. Seoane, Lorraine M. King, Tyler Risom, Lunden A. Simpson, Sujay Vennam, Aziz Khan, Luis Cisneros, Timothy Hardman, Bryan Harmon, Fergus Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla F. McAuliffe, Julie Nangia, Joanna Lee, Jennifer Tseng, Anna Maria Storniolo, Alastair M. Thompson, Gaorav P. Gupta, Robyn Burns, Deborah J. Veis, Katherine DeSchryver, Chunfang Zhu, Magdalena Matusiak, Jason Wang, Shirley X. Zhu, Jen Tappenden, Daisy Yi Ding, Dadong Zhang, Jingqin Luo, Shu Jiang, Sushama Varma, Lauren Anderson, Cody Straub, Sucheta Srivastava, Christina Curtis, Rob Tibshirani, Robert Michael Angelo, Allison Hall, Kouros Owzar, Kornelia Polyak, Carlo Maley, Jeffrey R. Marks, Graham A. Colditz, E. Shelley Hwang, Robert B. West
Publikováno v:
Scientia
Strand, S H, Rivero-Gutiérrez, B, Houlahan, K E, Seoane, J A, King, L M, Risom, T, Simpson, L A, Vennam, S, Khan, A, Cisneros, L, Hardman, T, Harmon, B, Couch, F, Gallagher, K, Kilgore, M, Wei, S, DeMichele, A, King, T, McAuliffe, P F, Nangia, J, Lee, J, Tseng, J, Storniolo, A M, Thompson, A M, Gupta, G P, Burns, R, Veis, D J, DeSchryver, K, Zhu, C, Matusiak, M, Wang, J, Zhu, S X, Tappenden, J, Ding, D Y, Zhang, D, Luo, J, Jiang, S, Varma, S, Anderson, L, Straub, C, Srivastava, S, Curtis, C, Tibshirani, R, Angelo, R M, Hall, A, Owzar, K, Polyak, K, Maley, C, Marks, J R, Colditz, G A, Hwang, E S & West, R B 2022, ' Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ : Analysis of TBCRC 038 and RAHBT cohorts ', Cancer Cell, vol. 40, no. 12, pp. 1521-1536.e7 . https://doi.org/10.1016/j.ccell.2022.10.021
Strand, S H, Rivero-Gutiérrez, B, Houlahan, K E, Seoane, J A, King, L M, Risom, T, Simpson, L A, Vennam, S, Khan, A, Cisneros, L, Hardman, T, Harmon, B, Couch, F, Gallagher, K, Kilgore, M, Wei, S, DeMichele, A, King, T, McAuliffe, P F, Nangia, J, Lee, J, Tseng, J, Storniolo, A M, Thompson, A M, Gupta, G P, Burns, R, Veis, D J, DeSchryver, K, Zhu, C, Matusiak, M, Wang, J, Zhu, S X, Tappenden, J, Ding, D Y, Zhang, D, Luo, J, Jiang, S, Varma, S, Anderson, L, Straub, C, Srivastava, S, Curtis, C, Tibshirani, R, Angelo, R M, Hall, A, Owzar, K, Polyak, K, Maley, C, Marks, J R, Colditz, G A, Hwang, E S & West, R B 2022, ' Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ : Analysis of TBCRC 038 and RAHBT cohorts ', Cancer Cell, vol. 40, no. 12, pp. 1521-1536.e7 . https://doi.org/10.1016/j.ccell.2022.10.021
Ductal carcinoma in situ; Tumor microenvironment; Whole genome sequencing Carcinoma ductal in situ; Microambiente tumoral; Secuenciación del genoma completo Carcinoma ductal in situ; Microambient tumoral; Seqüenciació del genoma complet Ductal car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5ce28cf6c965de1e61deadc35a7264
https://hdl.handle.net/11351/8732
https://hdl.handle.net/11351/8732
Autor:
Inmaculada C. Sorribes, Marc D. Ryser, Timothy Hardman, E. Shelley Hwang, Carlo C. Maley, Lorraine M. King, Darryl Shibata, Jeffrey R. Marks, Allison Hall, Sergei Tatishchev, Diego Mallo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
Intra-tumoral heterogeneity (ITH) could represent clonal evolution where subclones with greater fitness confer more malignant phenotypes and invasion constitutes an evolutionary bottleneck. Alternatively, ITH could represent branching evolution with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091fb3ea9f6e2aa62900f8fa63cfa6f5
http://link.springer.com/article/10.1038/s41467-020-14908-7
http://link.springer.com/article/10.1038/s41467-020-14908-7
Autor:
Chunfang Zhu, Siri H Strand, Daisy Yi Ding, Kristalyn K. Gallagher, Jose A. Seoane, Lunden A Simpson, Luis Cisneros, Allison Hall, Kornelia Polyak, Belén Rivero-Gutiérrez, Sucheta Srivastava, Kathleen E. Houlahan, Shirley Zhu, Cody Straub, Aziz Khan, Dadong Zhang, Magdalena Matusiak, Deborah J. Veis, Alastair M. Thompson, Mark R. Kilgore, Julie R. Nangia, Jeffrey R. Marks, Jennifer F. Tseng, Robert B. West, Timothy Hardman, Angela DeMichele, Graham A. Colditz, Anna Maria Storniolo, Tari King, Kouros Owzar, Jen Tappenden, E. Shelley Hwang, Robert M. Angelo, Joanna Lee, Shu Jiang, Sushama Varma, Carlo C. Maley, Priscilla F. McAuliffe, Lauren Anderson, Shi Wei, Katherine DeSchryver, Robert Tibshirani, Robyn Burns, Gaorav P. Gupta, Sujay Vennam, Bryan Harmon, Lorraine M. King, Christina Curtis, Jason K. Wang, Jingqin Luo, Tyler Risom, Fergus J. Couch
SUMMARYDuctal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We have performed the first multiscale, integrated profiling of DCIS with clinical outcomes by analyzing 67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d756705ca8fdb45c948c692a33a65913
https://doi.org/10.1101/2021.06.16.448585
https://doi.org/10.1101/2021.06.16.448585
Autor:
Angelo Fortunato, E. Shelley Hwang, Allison Hall, Diego Mallo, Joseph Y. Lo, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, Timothy Hardman, Shawn M. Rupp
Publikováno v:
Briefings in Bioinformatics
Most tissue collections of neoplasms are composed of formalin-fixed and paraffin-embedded (FFPE) excised tumor samples used for routine diagnostics. DNA sequencing is becoming increasingly important in cancer research and clinical management; however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fef238a633ec59b8d4210f264d4463
https://doi.org/10.1093/bib/bbab221
https://doi.org/10.1093/bib/bbab221
Autor:
Allison Hall, Lorraine M. King, Diego Mallo, Carlo C. Maley, Angelo Fortunato, Shelley Hwang, Jeffrey R. Marks, Timothy Hardman
Publikováno v:
Cancer Research. 79:P3-06
Background: Heterogeneity is a hallmark of human cancers that is apparent both between and within individual tumors. Intra-tumor heterogeneity provides the genetic fuel for natural selection in clonal evolution and cancer progression. Tumors with hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb59be008559c44a425c84226de5482b
https://doi.org/10.1158/1538-7445.sabcs18-p3-06-12
https://doi.org/10.1158/1538-7445.sabcs18-p3-06-12
Autor:
Deborah Collyar, Abeer M Shaaban, Tapsi Kumar, Mingchu Xu, Angelo Fortunato, Lorraine M. King, Marlous Hoogstraat, Sarah E Pinder, Nicholas N. Navin, Wim Brugman, Andrew Futreal, Maria Roman-Escorza, Marielle Krete, Mathini Sridharan, Alastair M. Thompson, Emi Sei, Anargyros Megalios, Diego Mallo, Jelle Wesseling, Frank Nieboer, Carolina Salinas-Souza, Michael Sheinman, Hilary Stobart, Lodewyk F. A. Wessels, Rana Shami, Ahmed A. Ahmed, Esther H. Lips, Jeffrey R. Marks, Serena Nik-Zainal, Lennart Mulder, Carlo C. Maley, Helen Davies, Salpie Nowinski, Vandna Shah, John Zhang, Karen Clements, Jelmar Quist, Michael Schaapveld, E. Shelley Hwang, Petra Kristel, Elinor J. Sawyer, Anita Grigoriadis, Liping Fu, Marjanka K. Schmidt, Lindy L. Visser, Brian A. Menegaz, Michiel de Maaker, Timothy Hardman
Pure ductal carcinoma in situ (DCIS) is being diagnosed more frequently through breast screening programmes and is associated with an increased risk of developing invasive breast cancer. We assessed the clonal relatedness of 143 cases of pure DCIS an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d34124ca76de07a15115ddabc2f67e1e
https://doi.org/10.1101/2021.03.22.21253209
https://doi.org/10.1101/2021.03.22.21253209