Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Timothy Hancox"'
Autor:
Laurent Salphati, Stewart J. Baker, Steve Price, Jim Nonomiya, Matthew C. Lucas, Timothy Hancox, David Knowles, Bohdan Waszkowycz, Neil Anthony Pegg, David Chantry, Bryan K. Chan, Paul Blaney, Anthony Brown, Steven T. Staben, Jodie Pang, Paul Depledge, Rama K. Kondru, Mark Ultsch, Paul Goldsmith, Karin Reif, Angelina Bisconte, Cristina Lewis, Eileen Mary Seward, Jeremy Murray, Brian Safina, Daniel P. Sutherlin, Zachary Kevin Sweeney, Georgette Castanedo, David Michael Goldstein, Jasmit Kaur, Sukhjit Sohal, Binqing Wei, John Lesnick, Stephen J. Shuttleworth, Alan Nadin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4296-4302
A potent inhibitor of PI3Kδ that is ⩾200 fold selective for the remaining three Class I PI3K isoforms and additional kinases is described. The hypothesis for selectivity is illustrated through structure activity relationships and crystal structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92be9aea35b7ac14f79d9d789ee6948b
https://doi.org/10.1016/j.bmcl.2012.05.027
https://doi.org/10.1016/j.bmcl.2012.05.027
Autor:
Suzanne A. Eccles, Pauline Moore, Lori Friedman, Paul A. Clarke, Stewart J. Baker, Olivero Alan G, Gary Box, Anthony Robson, Paul Workman, Khatereh Ahmadi, Laurent Salphati, Nahid Saghir, Giles Pergl-Wilson, Irina Chuckowree, Mark H. Ultsch, Wendy K. Alderton, Marketa Zvelebil, Florence I. Raynaud, Sukhjit Sohal, Arumugam Kugendradas, Christian Wiesmann, Adrian Folkes, Sonal Patel, Letitia Lensun, Angela Hayes, Timothy Hancox, Stephen J. Shuttleworth, Alexander Zhyvoloup, Heidi J.A. Wallweber, Paul Depledge, Melanie Valenti, Sonia Alix, Nan Chi Wan, Jodie Pang
Publikováno v:
Journal of Medicinal Chemistry. 51:5522-5532
Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation of the PI3K/ Akt signaling pathway in a wide variety of tumors. A series of thieno[3,2-d]pyrimidine derivatives were prepared and evaluated as inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de0e3ae091925e99a0f90135c014d5f
https://doi.org/10.1021/jm800295d
https://doi.org/10.1021/jm800295d
Autor:
Hayley Farmer, Peter Charlton, Simon Cocks, Paul Depledge, Richard Faint, Irina Chuckowree, Deanne Thompson, Shouming Wang, Nan Chi Wan, Adrian Folkes, John W. Scott, Jan Broadbridge, Stewart J. Baker, John R. Harrison, Anthony Boyce, Sukhjit Sohal, Timothy Hancox, Warren Miller, Francis Xavier Wilson, Prakash Mistry, Caroline Freathy
Publikováno v:
Journal of Medicinal Chemistry. 47:1339-1350
In our continued effort to identify selective MRP1 modulators, we have developed two novel templates, 3 and 4, through rational drug design by identifying the key pharmacophore interaction at the 7-position of the pyrrolopyrimidine template 1. Furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0bee0b02b3618e536f0b7b91a6b068
https://doi.org/10.1021/jm0310129
https://doi.org/10.1021/jm0310129
Autor:
Dalya R. Soond, Bart Vanhaesebroeck, Timothy Hancox, Heather Maecker, Ee Lyn Lim, Cheryl L. Scudamore, Thorsten Hagemann, Roberto Piñeiro, Wayne Pearce, Martin R Turner, Klaus Okkenhaug, Khaled Ali, Lori Friedman, Hicham Bouabe
Inhibitors against the p110δ isoform of phosphoinositide-3-OH kinase (PI(3)K) have shown remarkable therapeutic efficacy in some human leukaemias. As p110δ is primarily expressed in leukocytes, drugs against p110δ have not been considered for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d7f8a16ae33ac7a9264117648f1d4d
https://www.repository.cam.ac.uk/handle/1810/277584
https://www.repository.cam.ac.uk/handle/1810/277584
Autor:
Wayne Pearce, Lori Friedman, Hicham Bouabe, Timothy Hancox, Klaus Okkenhaug, Dalya R. Soond, Khaled Ali, Thorsten Hagemann, Bart Vanhaesebroeck, Roberto Piñeiro, Cheryl L. Scudamore, Heather Maecker, Ee Lyn Lim, Martin R Turner
Publikováno v:
Nature. 535:580-580
Nature 510, 407–411 (2014); doi:10.1038/nature13444 Queen Mary University London notified Nature and University College London that there is reason to question the provenance of the data for Fig. 5b, d, e of this Letter (Fig. 5a, c data are unaffec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ab77e150382f40f02aac25c6b2a532
https://doi.org/10.1038/nature17641
https://doi.org/10.1038/nature17641
Autor:
Steve Price, Georgette Castanedo, Fernando Padilla, Bohdan Waszkowycz, Christine Chabot, Neil Anthony Pegg, Laurent Salphati, Alan Nadin, Jun Li, Karin Reif, Raj K. Handa, Arnaud J. Cheguillaume, Timothy Hancox, Suzanne Tay, Pascal Savy, Parcharee Tivitmahaisoon, Zachary Kevin Sweeney, Jeremy Murray, Binqing Wei, Krintel Sussie Lerche, Qin Yue, Eileen Mary Seward, Sophie Mukadam, Rama K. Kondru, Pravin Iyer, Sukhjit Sohal, Jasmit Kaur, John Lesnick, Yung-Hsiang Chen, Daniel P. Sutherlin, Stephen J. Shuttleworth, Matthew W. Cartwright, Bindu Goyal, Paul M. Blaney, Paul Goldsmith, Jodie Pang, Matthew C. Lucas, Stewart J. Baker, Jim Nonomiya, Cristina Lewis, Wylie Solang Palmer, Chenghong Zhang, Brian Safina, Matt Baumgardner, Bryan K. Chan, David Michael Goldstein, Jane R. Kenny
Publikováno v:
Journal of medicinal chemistry. 55(12)
PI3Kδ is a lipid kinase and a member of a larger family of enzymes, PI3K class IA(α, β, δ) and IB (γ), which catalyze the phosphorylation of PIP2 to PIP3. PI3Kδ is mainly expressed in leukocytes, where it plays a critical, nonredundant role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f3151193dd85c9e07e1ac655378624
https://pubmed.ncbi.nlm.nih.gov/22626259
https://pubmed.ncbi.nlm.nih.gov/22626259
Autor:
John Milton, Wendy Dangerfield, Hamish Ryder, Richard Faint, Stephanie Hassan, Ian Dale, Pretswell Ian Andrew, Rory Dodd, Shouming Wang, Paul Depledge, Peter Charlton, Timothy Hancox
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
The syntheses and SAR studies of various quinazolinone compounds are described for the dual inhibition of Pgp and MRP1 in multidrug resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c85b17ff11309ca6edef55d7f4af1aa
https://pubmed.ncbi.nlm.nih.gov/11844674
https://pubmed.ncbi.nlm.nih.gov/11844674