Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Timothy Hamerly"'
Autor:
Timothy J. Garrett, Heather Coatsworth, Iqbal Mahmud, Timothy Hamerly, Caroline J. Stephenson, Jasmine B. Ayers, Hoda S. Yazd, Megan R. Miller, John A. Lednicky, Rhoel R. Dinglasan
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionSARS-CoV-2 subverts host cell processes to facilitate rapid replication and dissemination, and this leads to pathological inflammation.MethodsWe used niclosamide (NIC), a poorly soluble anti-helminth drug identified initially for repurpos
Externí odkaz:
https://doaj.org/article/f344e2a7e79e47e79fd946a495bfe7bc
Autor:
Vincent O. Nyasembe, Timothy Hamerly, Borja López-Gutiérrez, Alexandra M. Leyte-Vidal, Heather Coatsworth, Rhoel R. Dinglasan
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Plasmodium falciparum infection activates adipokinetic hormone signaling and lipid mobilization in the Anopheles gambiae mosquito vector to promote sporogony.
Externí odkaz:
https://doaj.org/article/ee9632754a8e4d8ead8278099162e3b1
Autor:
Nicole G. Bender, Prachi Khare, Juan Martinez, Rebecca E. Tweedell, Vincent O. Nyasembe, Borja López-Gutiérrez, Abhai Tripathi, Dustin Miller, Timothy Hamerly, Eric M. Vela, Ryan R. Davis, Randall F. Howard, Sandrine Nsango, Ronald R. Cobb, Matthias Harbers, Rhoel R. Dinglasan
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Malaria transmission-blocking vaccines (TBVs) prevent the completion of the developmental lifecycle of malarial parasites within the mosquito vector, effectively blocking subsequent infections. The mosquito midgut protein Anopheline alanyl a
Externí odkaz:
https://doaj.org/article/28e79b6e90d24744bdea15515a7a039e
Autor:
Gregory P. Howard, Nicole G. Bender, Prachi Khare, Borja López-Gutiérrez, Vincent Nyasembe, William J. Weiss, Jerry W. Simecka, Timothy Hamerly, Hai-Quan Mao, Rhoel R. Dinglasan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
A successful malaria transmission blocking vaccine (TBV) requires the induction of a high antibody titer that leads to abrogation of parasite traversal of the mosquito midgut following ingestion of an infectious bloodmeal, thereby blocking the cascad
Externí odkaz:
https://doaj.org/article/b57a063ffd7d4e87aa007842f02ce0da
Autor:
Timothy Hamerly, Rebecca E. Tweedell, Bernadette Hritzo, Vincent O. Nyasembe, Babu L. Tekwani, N. P. Dhammika Nanayakkara, Larry A. Walker, Rhoel R. Dinglasan
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Malaria is a major global health threat, with nearly half the world’s population at risk of infection. Given the recently described delayed clearance of parasites by artemisinin-combined therapies, new antimalarials are needed to facilitate the glo
Externí odkaz:
https://doaj.org/article/3b6b2e412ccb465fb984a6c2212ecd70
Autor:
Silvia Sanz, Eleonora Aquilini, Rebecca E. Tweedell, Garima Verma, Timothy Hamerly, Bernadette Hritzo, Abhai Tripathi, Marta Machado, Thomas S. Churcher, João A. Rodrigues, Luis Izquierdo, Rhoel R. Dinglasan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Thrombospondin type I repeat (TSR) domains are commonly O-fucosylated by protein O-fucosyltransferase 2 (PoFUT2), and this modification is required for optimal folding and secretion of TSR-containing proteins. The human malaria parasite Plasmodium fa
Externí odkaz:
https://doaj.org/article/03a8e10b72a04f759132e4392e6538c4
Autor:
Rebecca E. Tweedell, Dingyin Tao, Timothy Hamerly, Tanisha M. Robinson, Simon Larsen, Alexander G. B. Grønning, Alessandra M. Norris, Jonas G. King, Henry Chun Hin Law, Jan Baumbach, Elke S. Bergmann-Leitner, Rhoel R. Dinglasan
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
In vitro studies of liver stage (LS) development of the human malaria parasite Plasmodium falciparum are technically challenging; therefore, fundamental questions about hepatocyte receptors for invasion that can be targeted to prevent infection remai
Externí odkaz:
https://doaj.org/article/7230f2151b24475987bc989fc66f2ced
Autor:
Timothy Hamerly, Margaret H. Butler, Steve T. Fisher, Jonathan K. Hilmer, Garth A. James, Brian Bothner
Publikováno v:
AIMS Medical Science, Vol 2, Iss 3, Pp 150-161 (2015)
The ability to generate two-dimensional images of a wound that contains information about the distribution of bacteria overlaid with the distribution of drugs and metabolites could enhance our understanding of wound healing processes. Advances in tec
Externí odkaz:
https://doaj.org/article/b3331478fcca41e7a98ed8cd626aa8cf
Autor:
Timothy Hamerly, Brian Tripet, Louie Wurch, Robert L. Hettich, Mircea Podar, Brian Bothner, Valérie Copié
Publikováno v:
Archaea, Vol 2015 (2015)
Lipids composed of condensed isoprenyl units connected to glycerol backbones by ether linkages are a distinguishing feature of Archaea. Data suggesting that fatty acids with linear hydrocarbon chains are present in some Archaea have been available fo
Externí odkaz:
https://doaj.org/article/1055a2e53b7d4c9585adf42f9aff4b63
Autor:
Carlota Dobaño, Chenjerai Jairoce, Dídac Macià, Jorge Torres-Yaguana, Leonie Mayer, Marta Vidal, Rebeca Santano, Ramón Hurtado-Guerrero, Karine Reiter, David Narum, Borja Lopez-Gutierrez, Timothy Hamerly, Jahit Sacarlal, Ruth Aguilar, Rhoel Dinglasan, Gemma Moncunill, Luis Izquierdo
The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced IgGs recognise vaccine-like non-fucosylated PfCSP bett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::588fcd6d4ff41528d0b98a700bd30c08
https://doi.org/10.21203/rs.3.rs-2352899/v1
https://doi.org/10.21203/rs.3.rs-2352899/v1
