Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Timothy H. Murphy"'
Autor:
Ellen T. Koch, Judy Cheng, Daniel Ramandi, Marja D. Sepers, Alex Hsu, Tony Fong, Timothy H. Murphy, Eric Yttri, Lynn A. Raymond
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Huntington disease (HD) is a neurodegenerative disorder with complex motor and behavioural manifestations. The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of the human disease. Howe
Externí odkaz:
https://doaj.org/article/abbc69e7a5c44729926d173be44cabc4
Autor:
Yuhao Yan, Timothy H. Murphy
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114348- (2024)
Summary: The cortex and cerebellum form multi-synaptic reciprocal connections. We investigate the functional connectivity between single spiking cerebellar neurons and the population activity of the mouse dorsal cortex using mesoscale imaging. Cortic
Externí odkaz:
https://doaj.org/article/99ae995fbc3d478b9d381b9f2f131111
Publikováno v:
Frontiers in Research Metrics and Analytics, Vol 9 (2024)
Academic departments, research clusters and evaluators analyze author and citation data to measure research impact and to support strategic planning. We created Scholar Metrics Scraper (SMS) to automate the retrieval of bibliometric data for a group
Externí odkaz:
https://doaj.org/article/21b6160ee3a34932aacfb6ce9440c121
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
High content imaging of the brain holds the promise of improving our understanding of the brain’s circuitry. Here, the authors present a tool that automates the scaling and segmentation of cortical maps to accelerate neurobiological discovery using
Externí odkaz:
https://doaj.org/article/fe1ae3c950c14fc1ab4f4161487e086f
Autor:
Marja D. Sepers, James P. Mackay, Ellen Koch, Dongsheng Xiao, Majid H. Mohajerani, Allen W. Chan, Amy I. Smith-Dijak, Daniel Ramandi, Timothy H. Murphy, Lynn A. Raymond
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105740- (2022)
Huntington disease (HD), a hereditary neurodegenerative disorder, manifests as progressively impaired movement and cognition. Although early abnormalities of neuronal activity in striatum are well established in HD models, there are fewer in vivo stu
Externí odkaz:
https://doaj.org/article/6c6b2a489e66429e9fc1c4156edb5abf
Autor:
Timothy H. Murphy, Jamie D. Boyd, Federico Bolaños, Matthieu P. Vanni, Gergely Silasi, Dirk Haupt, Jeff M. LeDue
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Functional imaging in awake head-fixed mice is a widely used technique to study neural responses. Here the authors report on an open source, fully automated unsupervised system for training mice to self initiate head fixation to enable stable mesosco
Externí odkaz:
https://doaj.org/article/8b677be267364ad88171c99b778f3d8d
Autor:
Matthew P. Parsons, Matthieu P. Vanni, Cameron L. Woodard, Rujun Kang, Timothy H. Murphy, Lynn A. Raymond
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slice
Externí odkaz:
https://doaj.org/article/d4f6616d2af740d5b4e314bf2774e1ff
Publikováno v:
Neuron. 110:3688-3710
Multiscale neurophysiology reveals that simple motor actions are associated with changes in neuronal firing in virtually every brain region studied. Accordingly, the assessment of focal pathology such as stroke or progressive neurodegenerative diseas
Publikováno v:
Journal of Parkinson's Disease. 12:2085-2096
Human motion analysis has been a common thread across modern and early medicine. While medicine evolves, analysis of movement disorders is mostly based on clinical presentation and trained observers making subjective assessments using clinical rating
Autor:
Mehwish Anwer, Jeffrey LeDue, Zefang Wang, Sarah Wang, Wai Hang Cheng, Mariia Burdyniuk, Honor Cheung, Jianjia Fan, Carlos Barron, Peter A Cripton, Mark S Cembrowski, Fabio Rossi, Timothy H Murphy, Cheryl L Wellington
Despite the fundamental importance of understanding impaired brain activity exhibited in post-traumatic epilepsy and other neurological impairments associated with traumatic brain injury (TBI), knowledge of how brain injury affects neuronal activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb1063ee4f9427a645ab1d0709974cb5
https://doi.org/10.1101/2023.04.27.537761
https://doi.org/10.1101/2023.04.27.537761