Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Timothy H. Lucas"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract It is hypothesized that disparate brain regions interact via synchronous activity to control behavior. The nature of these interconnected ensembles remains an area of active investigation, and particularly the role of high frequency synchron
Externí odkaz:
https://doaj.org/article/b5c782b748f745949e8f7a979bfc95ea
Autor:
Lin Du, Han Hao, Yixiao Ding, Andrew Gabros, Thomas C. E. Mier, Jan Van der Spiegel, Timothy H. Lucas, Firooz Aflatouni, Andrew G. Richardson, Mark G. Allen
Publikováno v:
Microsystems & Nanoengineering, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract The sense of touch is critical to dexterous use of the hands and thus an essential component of efforts to restore hand function after amputation or paralysis. Prosthetic systems have addressed this goal with wearable tactile sensors. Howeve
Externí odkaz:
https://doaj.org/article/a6c38a8472ff4035b2d5d6da3c0b655a
Autor:
T. Campbell Arnold, Lohith G. Kini, John M. Bernabei, Andrew Y. Revell, Sandhitsu R. Das, Joel M. Stein, Timothy H. Lucas, Dario J. Englot, Victoria L. Morgan, Brian Litt, Kathryn A. Davis
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 559-570 (2023)
Abstract Objective Epilepsy surgery is an effective treatment for drug‐resistant patients. However, how different surgical approaches affect long‐term brain structure remains poorly characterized. Here, we present a semiautomated method for quant
Externí odkaz:
https://doaj.org/article/6e8b20f7f78e4b2e959c76e9d88b37bf
Autor:
Kayla Prezelski, Megan Keiser, Joel M. Stein, Timothy H. Lucas, Beverly Davidson, Pedro Gonzalez-Alegre, Flavia Vitale
Publikováno v:
Frontiers in Medical Technology, Vol 3 (2021)
Convection enhanced delivery (CED) allows direct intracranial administration of neuro-therapeutics. Success of CED relies on specific targeting and broad volume distributions (VD). However, to prevent off-target delivery and tissue damage, CED is typ
Externí odkaz:
https://doaj.org/article/3d98c385551b417cae2eea1117424af7
Autor:
Ankit N. Khambhati, Ari E. Kahn, Julia Costantini, Youssef Ezzyat, Ethan A. Solomon, Robert E. Gross, Barbara C. Jobst, Sameer A. Sheth, Kareem A. Zaghloul, Gregory Worrell, Sarah Seger, Bradley C. Lega, Shennan Weiss, Michael R. Sperling, Richard Gorniak, Sandhitsu R. Das, Joel M. Stein, Daniel S. Rizzuto, Michael J. Kahana, Timothy H. Lucas, Kathryn A. Davis, Joseph I. Tracy, Danielle S. Bassett
Publikováno v:
Network Neuroscience, Vol 3, Iss 3, Pp 848-877 (2019)
Chronically implantable neurostimulation devices are becoming a clinically viable option for treating patients with neurological disease and psychiatric disorders. Neurostimulation offers the ability to probe and manipulate distributed networks of in
Externí odkaz:
https://doaj.org/article/7b23708247584e1da29859ac6380f9eb
Autor:
Jacqueline Morris, Young-Ji Na, Hua Zhu, Jae-Hee Lee, Hoa Giang, Alexandra V. Ulyanova, Gordon H. Baltuch, Steven Brem, H. Isaac Chen, David K. Kung, Timothy H. Lucas, Donald M. O’Rourke, John A. Wolf, M. Sean Grady, Jai-Yoon Sul, Junhyong Kim, James Eberwine
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2706-2713 (2017)
Summary: A number of mitochondrial diseases arise from single-nucleotide variant (SNV) accumulation in multiple mitochondria. Here, we present a method for identification of variants present at the single-mitochondrion level in individual mouse and h
Externí odkaz:
https://doaj.org/article/27a7caa8a52541c2a8d3b84b4ce4f7e0
Autor:
Jennifer M. Spaethling, Young-Ji Na, Jaehee Lee, Alexandra V. Ulyanova, Gordon H. Baltuch, Thomas J. Bell, Steven Brem, H. Isaac Chen, Hannah Dueck, Stephen A. Fisher, Marcela P. Garcia, Mugdha Khaladkar, David K. Kung, Timothy H. Lucas Jr., Donald M. O’Rourke, Derek Stefanik, Jinhui Wang, John A. Wolf, Tamas Bartfai, M. Sean Grady, Jai-Yoon Sul, Junhyong Kim, James H. Eberwine
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 791-803 (2017)
Investigation of human CNS disease and drug effects has been hampered by the lack of a system that enables single-cell analysis of live adult patient brain cells. We developed a culturing system, based on a papain-aided procedure, for resected adult
Externí odkaz:
https://doaj.org/article/dfca0d124ee0410cac03e2216d6c2535
Autor:
Jennifer Stiso, Ankit N. Khambhati, Tommaso Menara, Ari E. Kahn, Joel M. Stein, Sandihitsu R. Das, Richard Gorniak, Joseph Tracy, Brian Litt, Kathryn A. Davis, Fabio Pasqualetti, Timothy H. Lucas, Danielle S. Bassett
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2554-2566.e7 (2019)
Summary: Optimizing direct electrical stimulation for the treatment of neurological disease remains difficult due to an incomplete understanding of its physical propagation through brain tissue. Here, we use network control theory to predict how stim
Externí odkaz:
https://doaj.org/article/27933cbb9dc34483afc23a7e74c38c80
Autor:
Preya Shah, John M. Bernabei, Lohith G. Kini, Arian Ashourvan, Jacqueline Boccanfuso, Ryan Archer, Kelly Oechsel, Sandhitsu R. Das, Joel M. Stein, Timothy H. Lucas, Danielle S. Bassett, Kathryn A. Davis, Brian Litt
Publikováno v:
NeuroImage: Clinical, Vol 23, Iss , Pp - (2019)
Patients with drug-resistant focal epilepsy are often candidates for invasive surgical therapies. In these patients, it is necessary to accurately localize seizure generators to ensure seizure freedom following intervention. While intracranial electr
Externí odkaz:
https://doaj.org/article/c6c3dad978db4afe807e81463ef3c7b9
Autor:
Vivek P. Buch, Andrew G. Richardson, Cameron Brandon, Jennifer Stiso, Monica N. Khattak, Danielle S. Bassett, Timothy H. Lucas
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Brain computer interfaces (BCIs) have been applied to sensorimotor systems for many years. However, BCI technology has broad potential beyond sensorimotor systems. The emerging field of cognitive prosthetics, for example, promises to improve learning
Externí odkaz:
https://doaj.org/article/758c893f662c45d888d1ed5b0b36aa1e