Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Timothy H. Click"'
Autor:
Tyler M. Weaver, Timothy H. Click, Thu H. Khoang, M. Todd Washington, Pratul K. Agarwal, Bret D. Freudenthal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Rev1 is a specialized translesion synthesis DNA polymerase involved in the bypass DNA damage during DNA replication. Here, the authors determine the structural basis for preferential incorporation of dCTP by Rev1 during bypass of DNA damage.
Externí odkaz:
https://doaj.org/article/910c77d8426543aaaf98c3556e2e1127
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3293-3302 (2021)
Ribonucleotides (rNTPs) are predicted to be incorporated into the genome at a rate of up to 3 million times per cell division, making rNTPs the most common non-standard nucleotide in the human genome. Typically, misinserted ribonucleotides are repair
Externí odkaz:
https://doaj.org/article/1cb17b3695494a05a1c0d6398ac3bf99
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 12, Pp 5292-5309 (2010)
Intrinsically disordered proteins (IDPs) are a newly recognized class of functional proteins that rely on a lack of stable structure for function. They are highly prevalent in biology, play fundamental roles, and are extensively involved in human dis
Externí odkaz:
https://doaj.org/article/2213762075ac4db29f3edb0910b40a29
Publikováno v:
Chemical Science. 13:3688-3696
A protein's adaptive response to its substrates is one of the key questions driving molecular physics and physical chemistry. This work employs the recently developed structure-mechanics statistical learning method to establish a mechanical perspecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8e01000d13c770eab2a4a202503b01
https://doi.org/10.1039/d1sc06184d
https://doi.org/10.1039/d1sc06184d
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5309-5320 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5309-5320 (2021)
Graphical abstract
Highlights • Statistical learning from protein dynamics unravels rigidities in interaction network. • Backbone and side-chain mechanical couplings exhibit scale-free network properties. • Graphical depiction of network r
Highlights • Statistical learning from protein dynamics unravels rigidities in interaction network. • Backbone and side-chain mechanical couplings exhibit scale-free network properties. • Graphical depiction of network r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8009d7bedf6462c8e8dadb6b6035e93e
https://doi.org/10.1016/j.csbj.2021.09.004
https://doi.org/10.1016/j.csbj.2021.09.004
Autor:
Bret D. Freudenthal, Pratul K Agarwal, T.M. Weaver, Thu H Khoang, Todd Washington, Timothy H. Click
Publikováno v:
Nature Communications. 13
Rev1 is a translesion DNA synthesis (TLS) polymerase involved in the bypass of adducted-guanine bases and abasic sites during DNA replication. During damage bypass, Rev1 utilizes a protein-template mechanism of DNA synthesis, where the templating DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8451a6d0ea8a9b678976c31289f351b
https://doi.org/10.1038/s41467-022-30577-0
https://doi.org/10.1038/s41467-022-30577-0
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3293-3302 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3293-3302 (2021)
Graphical abstract
Ribonucleotides (rNTPs) are predicted to be incorporated into the genome at a rate of up to 3 million times per cell division, making rNTPs the most common non-standard nucleotide in the human genome. Typically, misinserted ri
Ribonucleotides (rNTPs) are predicted to be incorporated into the genome at a rate of up to 3 million times per cell division, making rNTPs the most common non-standard nucleotide in the human genome. Typically, misinserted ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4627fe3304512c7249a8465befd98b
https://pubmed.ncbi.nlm.nih.gov/34188778
https://pubmed.ncbi.nlm.nih.gov/34188778
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 12, Pp 5292-5309 (2010)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Intrinsically disordered proteins (IDPs) are a newly recognized class of functional proteins that rely on a lack of stable structure for function. They are highly prevalent in biology, play fundamental roles, and are extensively involved in human dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43a6237dc94face1bb9b761412c82bf
http://www.mdpi.com/1422-0067/11/12/5292/
http://www.mdpi.com/1422-0067/11/12/5292/
Publikováno v:
Journal of Computational Chemistry. 32:513-524
We have simulated pure liquid butane, methanol and hydrated alanine polypeptide with the Monte Carlo technique using three kinds of random number generators - the standard Linear Congruential Generator (LCG), a modification of the LCG with additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411789f86ea27061a555f9455ab98d6f
https://doi.org/10.1002/jcc.21638
https://doi.org/10.1002/jcc.21638
CopZ is a copper chaperone from Bacillus subtilis. It is an important part of Cu(I) trafficking. We have calculated pK(a) values for the CXXC motif of this protein, which is responsible for the Cu(I) binding, and the Cu(I) binding constants. Polariza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3bb32245ade89524417e25a94ee43d
https://europepmc.org/articles/PMC3306534/
https://europepmc.org/articles/PMC3306534/
