Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Timothy H Florin"'
Autor:
Michael A. McGuckin, Julie M. Davies, Pascal Felgner, Kuan Yau Wong, Rabina Giri, Yaowu He, Md Moniruzzaman, Thomas Kryza, Haressh Sajiir, John D. Hooper, Timothy H. Florin, Jakob Begun, Abderrahim Oussalah, Sumaira Z. Hasnain, Michael Hensel, Yong H. Sheng
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 6, Pp 985-1009 (2023)
Background & Aims: MUC13 cell surface mucin is highly expressed on the mucosal surface throughout the intestine, yet its role against bacterial infection is unknown. We investigated how MUC13 impacts Salmonella typhimurium (S Tm) infection and elucid
Externí odkaz:
https://doaj.org/article/f2c1a11738f14b40a127bcac80dbb8db
Autor:
Ramya Movva, Nida Murtaza, Rabina Giri, Chin Wen Png, Julie Davies, Saleh Alabbas, Iulia Oancea, Páraic O'Cuiv, Mark Morrison, Jakob Begun, Timothy H. Florin
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 3, Pp 359-374 (2022)
Background and Aims: There is clinical interest in the sustainability or otherwise of prebiotic, microbial, and antibiotic treatments to both prevent and treat inflammatory bowel diseases. This study examined the role of antibiotic manipulation of th
Externí odkaz:
https://doaj.org/article/1c205f339420446d94e162e8111db893
Autor:
Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney, Iulia Oancea, Gregor Kijanka, Sumaira Hasnain, Andrew J. Lucke, David P. Fairlie, Michael A. McGuckin, Timothy H. Florin, Jakob Begun
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 33-53 (2021)
Background & Aims: Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD). Abnormal Wnt/β-catenin
Externí odkaz:
https://doaj.org/article/89948fa3daa4489086e5c513772d4acd
Autor:
Femke Crouwel, Melek Simsek, Amarylle S van Doorn, Chris J J Mulder, Hans J C Buiter, Murray L Barclay, Timothy H Florin, Nanne K de Boer
Publikováno v:
Crouwel, F, Simsek, M, van Doorn, A S, Mulder, C J J, Buiter, H J C, Barclay, M L, Florin, T H & de Boer, N K 2023, ' Rectally Administrated Thioguanine for Distal Ulcerative Colitis : A Multicenter Case Series ', Inflammatory Bowel Diseases, vol. 29, no. 6, pp. 1000-1004 . https://doi.org/10.1093/ibd/izac195
Inflammatory Bowel Diseases, 29(6), 1000-1004. John Wiley and Sons Inc.
Inflammatory Bowel Diseases, 29(6), 1000-1004. John Wiley and Sons Inc.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8eb4e383ab0f634d5f5207391918cd
https://doi.org/10.1093/ibd/izac195
https://doi.org/10.1093/ibd/izac195
Autor:
Saleh Y Alabbas, Rabina Giri, Iulia Oancea, Julie Davies, Veronika Schreibner, Timothy H Florin, Jakob Begun
Publikováno v:
Journal of Gastroenterology and Hepatology. 38:609-618
Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen, APAP) overdose remains a vexed health problem despite well publicised guidelines for its early detection and treatment. It is recognised that the gut may ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6e4516a8037a613e69d0013c080593
https://doi.org/10.1111/jgh.16102
https://doi.org/10.1111/jgh.16102
Autor:
Yong H. Sheng, Julie M. Davies, Ran Wang, Kuan Yau Wong, Rabina Giri, Yuanhao Yang, Jakob Begun, Timothy H. Florin, Sumaira Z. Hasnain, Michael A. McGuckin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology. 14:789-811
MUC1 is abnormally expressed in colorectal cancer, including colitis-associated colorectal cancer (CAC), but its role in tumorigenesis is unclear. This study investigated MUC1's effects in murine models of colitis and CAC and elucidated mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afa2a625c065fb28544ddf9d92d43e4
https://doi.org/10.1016/j.jcmgh.2022.06.010
https://doi.org/10.1016/j.jcmgh.2022.06.010
Autor:
Nripen Chanda, Nanne K. H. de Boer, Femke Crouwel, Chris J. J. Mulder, Timothy H. Florin, Ahmed B. Bayoumy, Hans J. C. Buiter
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics
Bayoumy, A B, Crouwel, F, Chanda, N, Florin, T H J, Buiter, H J C, Mulder, C J J & de Boer, N K H 2021, ' Advances in Thiopurine Drug Delivery: The Current State-of-the-Art ', European Journal of Drug Metabolism and Pharmacokinetics, vol. 46, no. 6, pp. 743-758 . https://doi.org/10.1007/s13318-021-00716-x
Bayoumy, A B, Crouwel, F, Chanda, N, Florin, T H J, Buiter, H J C, Mulder, C J J & de Boer, N K H 2021, ' Advances in Thiopurine Drug Delivery: The Current State-of-the-Art ', European Journal of Drug Metabolism and Pharmacokinetics, vol. 46, no. 6, pp. 743-758 . https://doi.org/10.1007/s13318-021-00716-x
Thiopurines (mercaptopurine, azathioprine and thioguanine) are well-established maintenance treatments for a wide range of diseases such as leukemia, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE) and other inflammatory and auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e498a56c54b40b77a4cd031f388902d8
http://europepmc.org/articles/PMC8599251
http://europepmc.org/articles/PMC8599251
Autor:
Iulia Oancea, Andy Wu, Michael A. McGuckin, Sumaira Z. Hasnain, Rabina Giri, John D. Hooper, Veronika Schreiber, Brett C McWhinney, Julie M. Davies, Jakob Begun, Yonghua Sheng, David P. Fairlie, Saleh Y. Alabbas, Gregor Kijanka, Yaowu He, Ramya Movva, Andrew J. Lucke, Timothy H. Florin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 33-53 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD). Abnormal Wnt/β-catenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f601ccce23a182b6171ce5a7c5598ec
http://www.sciencedirect.com/science/article/pii/S2352345X20300886
http://www.sciencedirect.com/science/article/pii/S2352345X20300886
Autor:
Martha Zakrzewski, Katherine Hanigan, Gillian Mahy, Miles P. Sparrow, Graham L. Radford-Smith, James D. Doecke, Ian C. Lawrance, Susan J. Connor, Peter A. Bampton, Richard B. Gearry, Jake Begun, Sally Bell, Anton Lord, Jane M. Andrews, Alissa Walsh, Krupa Krishnaprasad, Timothy H Florin, Grant W. Montgomery, Lisa A. Simms, Sally Mortlock
Publikováno v:
Journal of Crohn'scolitis.
Ulcerative colitis (UC) is a major form of inflammatory bowel disease with increasing global incidence. There is significant phenotypic heterogeneity defined by a range of clinical variables including age of onset and disease extent. Clinical outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9978e1fc0ae62c3e8068df8e86d84a5
https://pubmed.ncbi.nlm.nih.gov/36111848
https://pubmed.ncbi.nlm.nih.gov/36111848
Autor:
Melek Simsek, Rupa Banerjee, Javier P. Gisbert, Adriaan A. van Bodegraven, Rupert W. Leong, Azhar Ansari, Graham L. Radford-Smith, Vineet Ahuja, Margien L. Seinen, Richard B. Gearry, Timothy H. Florin, David P. Epstein, Nanne K. H. de Boer, Jean-Frederic Colombel, Sven Almer, Chris J. J. Mulder, Jake Begun, Murray L. Barclay, Miles P. Sparrow, Markus F. Neurath
Publikováno v:
de Boer, N K H, Thiopurine Working Group, Ahuja, V, Almer, S, Ansari, A, Banerjee, R, Barclay, M L, Begun, J, van Bodegraven, A A, Colombel, J-F, Epstein, D P, Florin, T H J, Gearry, R B, Gisbert, J P, Leong, R W, Mulder, C J J, Neurath, M F, Radford-Smith, G L, Seinen, M L, Simsek, M & Sparrow, M P 2019, ' Thiopurine Therapy in Inflammatory Bowel Diseases: Making New Friends Should Not Mean Losing Old Ones ', Gastroenterology, vol. 156, no. 1, pp. 11-14 . https://doi.org/10.1053/j.gastro.2018.11.039
Gastroenterology, 156(1), 11-14. W.B. Saunders Ltd
Gastroenterology, 156(1), 11-14. W.B. Saunders Ltd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21d90faaf9b579f3c56ea5dc3f15e2b
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058876383&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058876383&origin=inward