Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Timothy G. Terrell"'
Autor:
H. Ramon Widmer, James R. Hully, Ralph H. Schwall, Nancy Gillett, Timothy G. Terrell, Ling Chang
Publikováno v:
Hepatology. 20:854-862
Recombinant human activin A, a member of the transforming growth factor-β superfamily, induced significant cell loss in rodent livers and in primary hepatocyte cultures. Histologically and biochemically the hepatocyte death was mediated by apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979e95848f4057cab8591dd61a5a6dd1
https://doi.org/10.1002/hep.1840200413
https://doi.org/10.1002/hep.1840200413
Autor:
Timothy G. Terrell, James D. Green
Publikováno v:
Toxicologic Pathology. 22:187-193
The emergence of the biotechnology industry and introduction of drugs derived from recombinant DNA technology has generated many new issues in approaches to preclinical safety evaluation and extrapolation of results to risk assessment in humans. Prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c57af4769dd5148903457b38d3ad7a
https://doi.org/10.1177/019262339402200212
https://doi.org/10.1177/019262339402200212
Publikováno v:
Endocrinology. 131:2540-2544
Hepatocyte growth factor (HGF) is a potent stimulator of DNA synthesis in cultured hepatocytes. To determine whether HGF has any activity in vivo, we have tested HGF in rats in which intrahepatic cholestasis was induced by acute administration of alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb8f0648086261c7529baa99129a20b
https://doi.org/10.1210/endo.131.6.1446596
https://doi.org/10.1210/endo.131.6.1446596
Autor:
Anne M. Ryan, Timothy G. Terrell
Publikováno v:
Handbook of Toxicologic Pathology (Second Edition)
This chapter explores about biotechnology and its products. Recent scientific advances in molecular biology, recombinant DNA technology, and monoclonal antibody production have led to the development of a new class of therapeutic agents, biopharmaceu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1d78b3bcb62ec63c3fa4607f1612885
https://doi.org/10.1016/b978-012330215-1/50021-1
https://doi.org/10.1016/b978-012330215-1/50021-1
Autor:
Timothy G. Terrell, James D. Green
Publisher Summary This chapter discusses the data obtained from a series of toxicity studies with rHu (interferon) IFN- γ in a variety of species and presents a comparison of those findings with data from studies with recombinant murine IFN- γ (rMu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::167efcd6ee1e9d20a4d85609a75f57cc
https://doi.org/10.1016/b978-0-12-364935-5.50011-0
https://doi.org/10.1016/b978-0-12-364935-5.50011-0
The systemic administration of high doses of rHuTGF-beta 1 to rats produced a spectrum of lesions in multiple target tissues, including liver, bone, kidney, heart, thymus, pancreas, stomach, cecum, at the injection vein, and in skeletal muscle at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f02a95dfe9cf530241cb71d9b17c89c
https://doi.org/10.1016/b978-0-12-364935-5.50009-2
https://doi.org/10.1016/b978-0-12-364935-5.50009-2
Autor:
Kathy Barrett, M. Patricia Beckmann, C. Paul Chow, William C. Fanslow, Adriano Fontana, Michael Fountoulakis, Brian Foxwell, Karl Frei, Gianni Garotta, Reiner Gentz, Georges E. Grau, James D. Green, Cindy A. Jacobs, Thomas C. Jones, Steven L. Kunkel, Paul-Henri Lambert, Gerhard Leitz, David H. Lynch, Charles R. Maliszewski, M.J. Mihatsch, Ken Mohler, Laurence Ozmen, Hans-Walter Pfister, Daniela Piani, Pierre-François Piguet, Daniel G. Remick, Frank Rosenkaimer, Antal Rot, Bernhard Ryffel, Gerhard G. Steinmann, Angelika C. Stern, Timothy G. Terrell, Pierre Vassalli, Alfred Walz, Peter K. Working, Roland Zwahlen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e3689a1997934a62fd1568b49e3f3a
https://doi.org/10.1016/b978-0-12-364935-5.50004-3
https://doi.org/10.1016/b978-0-12-364935-5.50004-3
Autor:
Timothy G. Terrell, James D. Green
Publikováno v:
Toxicology letters.
Interferon-gamma is an immunomodulatory cytokine that has an extremely restricted host range of activities. RhIFN-gamma was one of the first species-specific recombinant proteins to be assessed in conventional safety models typically utilized for xen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37827a99eac89582a41b970e9fe15b5a
https://pubmed.ncbi.nlm.nih.gov/1471187
https://pubmed.ncbi.nlm.nih.gov/1471187
Dermal Sensitization Study in Hairless Guinea Pigs with Dinitrochlorobenzene and Ethyl Aminobenzoate
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 7:273-281
This study was designed to investigate the use of adult female hairless guinea pigs, bred at Charles River Laboratories, Inc. (CRL-IAF(HA)BR), as a model for dermal sensitization studies. These animals are euthymic and hairless except for continuous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccb539b95f506eb483ddd6d45483788d
https://doi.org/10.3109/15569528809056307
https://doi.org/10.3109/15569528809056307
Publikováno v:
The American journal of tropical medicine and hygiene. 22(6)
The histopathology of Machupo virus infection in intracerebrally inoculated suckling hamsters was studied and compared to the histopathology of a virus isolated from a case of hemorrhagic fever from Cochabamba, Bolivia. Both virus isolates were patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f8a12d75f9a47e8e006954cca215d4
https://pubmed.ncbi.nlm.nih.gov/4745242
https://pubmed.ncbi.nlm.nih.gov/4745242