Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Timothy G. Heath"'
Autor:
Ashit Trivedi, Min Zhu, John P. Gibbs, Sreeneeranj Kasichayanula, S Stienen, H Li, Theresa Yuraszeck, R Loberg, Timothy G. Heath
Publikováno v:
Clinical and Translational Science. 10:147-162
Development of bispecific antibodies (BsAbs) as therapeutic agents has recently attracted significant attention, and investments in this modality have been steadily increasing. This review discusses challenges, and suggestions to overcome them, assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d9856858051d7399fb41141e0578b68
https://doi.org/10.1111/cts.12459
https://doi.org/10.1111/cts.12459
Publikováno v:
Protein Analysis using Mass Spectrometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8532524e0a8044fb71c7e9552ccaaf53
https://doi.org/10.1002/9781119371779.ch12
https://doi.org/10.1002/9781119371779.ch12
Autor:
Ying Yu, Haodan Yuan, Jonathan Chupka, Bo Feng, Jenny Y. Zheng, Brian R. Bond, Timothy G. Heath
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 330:191-197
In humans and rats, a synergistic blood pressure reduction was observed when the fibrate gemcabene (CI-1027) was coadministered with the angiotensin-converting enzyme inhibitor quinapril. In a quinapril (3 mg/kg) pharmacokinetic rat study, there was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9858044871e5c4b87ba2b79001aa13db
https://doi.org/10.1124/jpet.108.149476
https://doi.org/10.1124/jpet.108.149476
Autor:
Judith Skaptason, Janice Bower, Emi Kimoto, Timothy G. Heath, David Romero, Lisa N. Toth, Shinji Yamazaki
Publikováno v:
Drug Metabolism and Disposition. 37:937-945
The primary objective of this study was to demonstrate the use of stable isotope (SI)-labeled compound as an approach for pharmacokinetic analysis such as fraction absorbed, hepatic extraction ratio, and fraction metabolized from the parent drug to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8760c60ab32d8b415c1309c1aa18d936
https://doi.org/10.1124/dmd.108.025478
https://doi.org/10.1124/dmd.108.025478
Autor:
Jessica Ortiz, Sergio Sanchez, Christian Vettermann, Hannah P. Victor, Timothy G. Heath, Mark Ma, Shalini Gupta, Stephanie A. Lee
Publikováno v:
Journal of immunological methods. 429
Neutralizing anti-drug antibodies (NAbs) can adversely impact efficacy and safety of biologic therapeutics. However, current assay formats to detect NAbs are limited in their use during the dosing phase due to interference by circulating drug, result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833bcfcfe83225b139ee37a5cf9fc317
https://pubmed.ncbi.nlm.nih.gov/26711311
https://pubmed.ncbi.nlm.nih.gov/26711311
Autor:
Timothy G. Heath, Dennis O. Scott
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 17:17-25
MDL 100,907 is a selective 5-HT 2a receptor antagonist which is currently being developed for the treatment of schizophrenia. Pharmacokinetic studies of MDL 100,907 in rats and dogs show that the drug is well absorbed but undergoes extensive first-pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9d631c11fc994265e5d0a87fb0ac13
https://doi.org/10.1016/s0731-7085(97)00144-1
https://doi.org/10.1016/s0731-7085(97)00144-1
Autor:
Timothy G. Heath, Dennis O. Scott
Publikováno v:
Journal of the American Society for Mass Spectrometry. 8:371-379
A method based on liquid chromatography-tandem mass spectrometry and microbore column separation was developed for the quantification of a potent 5-HT2a receptor antagonist (R)-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)etnyl]-4-piperidine-met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ed714c5d3e05c8f0b6ae1d1458439e
https://doi.org/10.1016/s1044-0305(96)00289-9
https://doi.org/10.1016/s1044-0305(96)00289-9
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 688:281-289
Characterizing components eluting from a HPLC column is enhanced when multiple detectors are incorporated in-line. The performance of a system consisting of a combination of two detectors-electrospray ionization mass spectrometry (and tandem mass spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2927b8fe74b6c155ff478cf0e4c5a5a1
https://doi.org/10.1016/s0378-4347(96)00299-x
https://doi.org/10.1016/s0378-4347(96)00299-x
Autor:
Gregory G. Dolnikowski, Christian Rolando, James H. Scrivens, Timothy G. Heath, J. Throck Watson
Publikováno v:
Journal of the American Society for Mass Spectrometry. 2(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462c2d6ccb8fdf74a5cf45a537933b16
https://pubmed.ncbi.nlm.nih.gov/24242283
https://pubmed.ncbi.nlm.nih.gov/24242283
Autor:
Paul C. Toren, Timothy G. Heath, Bradley S. Mathews, Jim Chang, Be-Sheng Kuo, Janice I. Carroll, Dennis O. Scott, D. Darlene Massad
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 670:91-101
MDL 100,240 ([4S-[4α,7α(R ∗ ), 12 b β]] - 7 - [[2 - ( acetylthio )-1- oxo - 3 - phenylpropyl ] amino ] - 1,2,3,4,6,7,8,12b - octahydro - 6 - oxo - pyrido [2,1 - a][2] benzazepine - 4 - carboxylic acid, I ) is the thioacetyl prodrug of the active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b014626342cde61673e39e99c8cb008
https://doi.org/10.1016/0378-4347(95)00134-5
https://doi.org/10.1016/0378-4347(95)00134-5