Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Timothy G. Freels"'
Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit
Autor:
Susanna Molas, Timothy G. Freels, Rubing Zhao-Shea, Timothy Lee, Pablo Gimenez-Gomez, Melanie Barbini, Gilles E. Martin, Andrew R. Tapper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Animals are inherently motivated to explore social novelty cues over familiar ones, resulting in a novelty preference (NP), although the behavioral and circuit bases underlying NP are unclear. Combining calcium and neurotransmitter sensors w
Externí odkaz:
https://doaj.org/article/749a60f9c4244567b2a40f1e3566d5fb
Autor:
Nicholas C. Glodosky, Carrie Cuttler, Timothy G. Freels, Hayden R. Wright, Manuel J. Rojas, Samantha L. Baglot, Matthew N. Hill, Ryan J. McLaughlin
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100260- (2020)
Rationale: Cannabis users frequently report stress relief as their primary reason for use. Recent studies indicate that human cannabis users exhibit blunted stress reactivity; however, it is unknown whether this is a cause or a consequence of chronic
Externí odkaz:
https://doaj.org/article/e439e737b12147d4b654e092dc9db3a5
Autor:
Timothy G. Freels, Sara R. Westbrook, Hayden R. Wright, Jacqulyn R. Kuyat, Erica Zamberletti, Alexandra M. Malena, Max W. Melville, Amanda M. Brown, Nicholas C. Glodosky, Darren E. Ginder, Courtney M. Klappenbach, Kristen M. Delevich, Tiziana Rubino, Ryan J. McLaughlin
Cannabis is the most used illicit drug in the United States. With many states passing legislation to permit its recreational use, there is concern that cannabis use among adolescents could increase dramatically in the coming years. Historically, it h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c71927decd91ae01bd7b3efe25a551
https://doi.org/10.1101/2023.01.21.524468
https://doi.org/10.1101/2023.01.21.524468
Publikováno v:
eNeuro.
Midbrain dopaminergic (DAergic) neurons of the ventral tegmental area (VTA) are engaged by rewarding stimuli and encode reward prediction error to update goal-directed learning. However, recent data indicate that VTA DAergic neurons are functionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f193c9611449cc656b2c32925adeac
https://pubmed.ncbi.nlm.nih.gov/36599671
https://pubmed.ncbi.nlm.nih.gov/36599671
Publikováno v:
Psychopharmacology. 238:991-1004
Optimal decision-making necessitates evaluation of multiple rewards that are each offset by distinct costs, such as high effort requirement or high risk of failure. The neurotransmitter dopamine is fundamental toward these cost-benefit analyses, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c963e85ceaa1b0ed4bef1f2f5f3f3965
https://doi.org/10.1007/s00213-020-05745-z
https://doi.org/10.1007/s00213-020-05745-z
Publikováno v:
Neuropsychopharmacology
The risky decision-making task (RDT) measures risk-taking in a rat model by assessing preference between a small, safe reward and a large reward with increasing risk of punishment (mild foot shock). It is well-established that dopaminergic drugs modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54d05294d07673d8bb5b4d77ff48bfa
https://doi.org/10.1038/s41386-019-0527-0
https://doi.org/10.1038/s41386-019-0527-0
Publikováno v:
Behavioural Brain Research. 359:579-588
Excessive risk-taking is common in multiple psychiatric conditions, including substance use disorders. The risky decision-making task (RDT) models addiction-relevant risk-taking in rats by measuring preference for a small food reward vs. a large food
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8706e6fa9018308e54ba587241c4757b
https://doi.org/10.1016/j.bbr.2018.10.008
https://doi.org/10.1016/j.bbr.2018.10.008
Publikováno v:
Neuropsychopharmacology
A critical brain area implicated in nicotine dependence is the interpeduncular nucleus (IPN) located in the ventral midbrain and consisting primarily of GABAergic neurons. Previous studies indicate that IPN GABAergic neurons contribute to expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28770e2f74fe5cf4f333f1ea8786d706
https://pubmed.ncbi.nlm.nih.gov/34593977
https://pubmed.ncbi.nlm.nih.gov/34593977
Autor:
Carrie Cuttler, Manuel J. Rojas, Matthew N. Hill, Samantha L. Baglot, Ryan J. McLaughlin, Nicholas C. Glodosky, Hayden R. Wright, Timothy G. Freels
Publikováno v:
Neurobiology of Stress
Neurobiology of Stress, Vol 13, Iss, Pp 100260-(2020)
Neurobiology of Stress, Vol 13, Iss, Pp 100260-(2020)
Rationale Cannabis users frequently report stress relief as their primary reason for use. Recent studies indicate that human cannabis users exhibit blunted stress reactivity; however, it is unknown whether this is a cause or a consequence of chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a491750cccae696180bc418d3c2c5b5
http://europepmc.org/articles/PMC7739171
http://europepmc.org/articles/PMC7739171