Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Timothy G Jenkins"'
Autor:
Patrick J Murphy, Jingtao Guo, Timothy G Jenkins, Emma R James, John R Hoidal, Thomas Huecksteadt, Dallin S Broberg, James M Hotaling, David F Alonso, Douglas T Carrell, Bradley R Cairns, Kenneth I Aston
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008756 (2020)
Paternal cigarette smoke (CS) exposure is associated with increased risk of behavioral disorders and cancer in offspring, but the mechanism has not been identified. Here we use mouse models to investigate mechanisms and impacts of paternal CS exposur
Externí odkaz:
https://doaj.org/article/f1c39d09b6eb4aa9abd6df5fcde7696e
Autor:
Sorena Keihani, James R Craig, Chong Zhang, Angela P Presson, Jeremy B Myers, William O Brant, Kenneth I Aston, Benjamin R Emery, Timothy G Jenkins, Douglas T Carrell, James M Hotaling
Publikováno v:
Asian Journal of Andrology, Vol 20, Iss 3, Pp 290-293 (2018)
Proton-pump inhibitors (PPIs) are among the most widely used drugs worldwide. PPI use has recently been linked to adverse changes in semen quality in healthy men; however, the effects of PPI use on semen parameters remain largely unknown specifically
Externí odkaz:
https://doaj.org/article/411c997574e7450abc7db5d8efb8398a
Autor:
Jin Zhou, Timothy G Jenkins, Alesia M Jung, Kyoung Sook Jeong, Jing Zhai, Elizabeth T Jacobs, Stephanie C Griffin, Devi Dearmon-Moore, Sally R Littau, Wayne F Peate, Nathan A Ellis, Peter Lance, Yin Chen, Jefferey L Burgess
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214282 (2019)
Firefighters are exposed to carcinogens and have elevated cancer rates. We hypothesized that occupational exposures in firefighters would lead to DNA methylation changes associated with activation of cancer pathways and increased cancer risk. To addr
Externí odkaz:
https://doaj.org/article/803476579a1745a081af118592db6940
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004458 (2014)
Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It is well established that various neuropsychiatric disorders (schizophrenia, autism, etc.), trinucleotide expansion associated diseases (myotonic dystrophy,
Externí odkaz:
https://doaj.org/article/ae3f77a707f34631980ecf0911fe0f17
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background As the average age of fatherhood increases worldwide, so too does the need for understanding effects of aging in male germline cells. Molecular change, including epigenomic alterations, may impact offspring. Age-associated change
Externí odkaz:
https://doaj.org/article/5cc65ef36d3240949518b3115a3923b6
Autor:
Liina Nagirnaja, Alexandra M. Lopes, Wu-Lin Charng, Brian Miller, Rytis Stakaitis, Ieva Golubickaite, Alexandra Stendahl, Tianpengcheng Luan, Corinna Friedrich, Eisa Mahyari, Eloise Fadial, Laura Kasak, Katinka Vigh-Conrad, Manon S. Oud, Miguel J. Xavier, Samuel R. Cheers, Emma R. James, Jingtao Guo, Timothy G. Jenkins, Antoni Riera-Escamilla, Alberto Barros, Filipa Carvalho, Susana Fernandes, João Gonçalves, Christina A. Gurnett, Niels Jørgensen, Davor Jezek, Emily S. Jungheim, Sabine Kliesch, Robert I. McLachlan, Kenan R. Omurtag, Adrian Pilatz, Jay I. Sandlow, James Smith, Michael L. Eisenberg, James M. Hotaling, Keith A. Jarvi, Margus Punab, Ewa Rajpert-De Meyts, Douglas T. Carrell, Csilla Krausz, Maris Laan, Moira K. O’Bryan, Peter N. Schlegel, Frank Tüttelmann, Joris A. Veltman, Kristian Almstrup, Kenneth I. Aston, Donald F. Conrad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The GEMINI consortium sequenced 1,000 cases of idiopathic male infertility and identified a plausible Mendelian cause in 20% of cases. The infertility genes can be grouped by expression pattern, facilitating their interpretation and follow-up.
Externí odkaz:
https://doaj.org/article/d33757f275f346459883626f17daf68f
Autor:
Timothy G. Jenkins, Zhen Chen, Traci E Clemons, James L. Mills, Lindsey A. Sjaarda, C. Matthew Peterson, Sunni L. Mumford, Kayla Chaney, Erica Johnstone, Amy E.T. Sparks, Benjamin R. Emery, Elizabeth A. DeVilbiss, Neil J. Perkins, Kenneth I. Aston, Enrique F Schisterman, James M. Hotaling, Douglas T. Carrell
Publikováno v:
Fertility and Sterility. 117:75-85
Objective To determine if 6-month folic acid (5 mg) and zinc (30 mg) supplementation impacts sperm DNA methylation patterns. Design A multicenter, double-blind, block randomized, placebo-controlled trial titled “The Folic Acid and Zinc Supplementat
Autor:
Alesia M. Jung, Todd A. Stueckle, Jaclyn M. Goodrich, Angela L. Slitt, Alberto J. Caban-Martinez, Jeff Hughes, Darin D. Wallentine, Sally R. Littau, Shawn C. Beitel, Jefferey L. Burgess, Antonia M. Calafat, Amy Nematollahi, John Gulotta, Alisa L Dewald, Casey Grant, Charles Popp, Judith M. Graber, Timothy G. Jenkins, Miriam M. Calkins, Julianne Cook Botelho
Publikováno v:
Epigenomics
Background: Per- and polyfluoroalkyl substances (PFASs) are persistent chemicals that firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as PFASs toxicity biomarkers. Methods: With a sample size of 197 firefighte
Autor:
Raheel Samuel, Haidong Feng, Bruce K. Gale, Kenneth I. Aston, Alex Jafek, James M. Hotaling, Timothy G. Jenkins
Publikováno v:
The Analyst. 146:3368-3377
Immotile and rare sperm isolation from a complex cell background is an essential process for infertility treatment. The traditional sperm collection process from a biopsy sample requires long, tedious searches, yet still results in low sperm retrieva
Autor:
Hayden Brady, Marzieh Chaharlang, Raheel Samuel, Alex Jafek, Timothy G. Jenkins, Kevin E. Petersen, Bruce K. Gale, Kenneth I. Aston, Haidong Feng
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Sperm preparation is critical to achieving a successful intrauterine insemination and requires the processing of a semen sample to remove white blood cells, wash away seminal plasma, and reduce sample volume. We present an automated instrument capabl