Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Timothy G Geary"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009828 (2021)
Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals and plants. Despite great differences in their life cycles, host preference and transmission modes, these parasites share a common capacity to manipulate their
Externí odkaz:
https://doaj.org/article/b69745fa329f4bf79a314a4a95810598
Autor:
Karine Sonzogni-Desautels, Thomas Z Di Lenardo, Axel E Renteria, Marc-André Gascon, Timothy G Geary, Momar Ndao
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e0007259 (2019)
Cryptosporidiosis caused by the protozoan parasites Cryptosporidium hominis and C. parvum, threatens the lives of young children in developing countries. In veterinary medicine, C. parvum causes life-threatening diarrhea and dehydration in newborn da
Externí odkaz:
https://doaj.org/article/0c0d857e3d734151acb196e548867e4b
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0006436 (2019)
Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It h
Externí odkaz:
https://doaj.org/article/28566c3e692349a3a00977e4cca7341b
Autor:
Rajesh M Valanparambil, Mifong Tam, Pierre-Paul Gros, Jean-Philippe Auger, Mariela Segura, Philippe Gros, Armando Jardim, Timothy G Geary, Keiko Ozato, Mary M Stevenson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006647 (2017)
Interferon regulatory factor-8 (IRF-8) is critical for Th1 cell differentiation and negatively regulates myeloid cell development including myeloid-derived suppressor cells (MDSC). MDSC expand during infection with various pathogens including the gas
Externí odkaz:
https://doaj.org/article/7ed5a4d98cc749188793e07309153a83
Autor:
Cristina Ballesteros, Lucienne Tritten, Maeghan O'Neill, Erica Burkman, Weam I Zaky, Jianguo Xia, Andrew Moorhead, Steven A Williams, Timothy G Geary
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004929 (2016)
BACKGROUND:Lymphatic filariasis and onchocerciasis are disabling and disfiguring neglected tropical diseases of major importance in developing countries. Ivermectin is the drug of choice for mass drug administration programs for the control of onchoc
Externí odkaz:
https://doaj.org/article/d3b53452fdca4f4d9f24ce3a220ad952
Autor:
Maeghan O'Neill, Abdelmoneim Mansour, Utami DiCosty, James Geary, Michael Dzimianski, Scott D McCall, John W McCall, Charles D Mackenzie, Timothy G Geary
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004698 (2016)
Current control strategies for onchocerciasis and lymphatic filariasis (LF) rely on prolonged yearly or twice-yearly mass administration of microfilaricidal drugs. Prospects for near-term elimination or eradication of these diseases would be improved
Externí odkaz:
https://doaj.org/article/796e5ec4734640cb8dc32e004100f353
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004624 (2016)
Helminth infections affect more than a third of the world's population. Despite very broad phylogenetic differences among helminth parasite species, a systemic Th2 host immune response is typically associated with long-term helminth infections, also
Externí odkaz:
https://doaj.org/article/eceec56b626c4ed6b55879553d2ea6d6
Autor:
Cristina Ballesteros, Lucienne Tritten, Maeghan O'Neill, Erica Burkman, Weam I Zaky, Jianguo Xia, Andrew Moorhead, Steven A Williams, Timothy G Geary
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004311 (2016)
BACKGROUND:Filarial nematodes cause serious and debilitating infections in human populations of tropical countries, contributing to an entrenched cycle of poverty. Only one human filarial parasite, Brugia malayi, can be maintained in rodents in the l
Externí odkaz:
https://doaj.org/article/be027c0b99ec46449af88628f537a085
Autor:
Daniel Kulke, Georg von Samson-Himmelstjerna, Sandra M Miltsch, Adrian J Wolstenholme, Aaron R Jex, Robin B Gasser, Cristina Ballesteros, Timothy G Geary, Jennifer Keiser, Simon Townson, Achim Harder, Jürgen Krücken
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 12, p e3401 (2014)
The cyclooctadepsipeptide emodepside and its parent compound PF1022A are broad-spectrum nematicidal drugs which are able to eliminate nematodes resistant to other anthelmintics. The mode of action of cyclooctadepsipeptides is only partially understoo
Externí odkaz:
https://doaj.org/article/eee59e0458bc4c27a811a0d3f320d95e
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 6, p e2939 (2014)
Strategies employed by parasites to establish infections are poorly understood. The host-parasite interface is maintained through a molecular dialog that, among other roles, protects parasites from host immune responses. Parasite excretory/secretory
Externí odkaz:
https://doaj.org/article/ea7bac288037479fb2509a35276e6a19