Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Timothy G, Keys"'
Autor:
Aline Cuénod, Jessica Agnetti, Helena M. B. Seth-Smith, Tim Roloff, Denise Wälchli, Dimitri Shcherbakov, Rashid Akbergenov, Sarah Tschudin-Sutter, Stefano Bassetti, Martin Siegemund, Christian H. Nickel, Jacob Moran-Gilad, Timothy G. Keys, Valentin Pflüger, Nicholas R. Thomson, Adrian Egli
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, often caused by uropathogenic Escherichia coli. Multiple bacterial virulence factors or patient characteristics have been linked separately
Externí odkaz:
https://doaj.org/article/24bce8ec0d7249b99753281a7d7df2ce
Autor:
Hanne L. P. Tytgat, Chia-wei Lin, Mikail D. Levasseur, Markus B. Tomek, Christoph Rutschmann, Jacqueline Mock, Nora Liebscher, Naohiro Terasaka, Yusuke Azuma, Michael Wetter, Martin F. Bachmann, Donald Hilvert, Markus Aebi, Timothy G. Keys
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Established bacterial glycoengineering platforms limit access to protein and glycan substrates. Here the authors design a cytoplasmic protein glycosylation system, Glycoli, to generate a variety of multivalent glycostructures.
Externí odkaz:
https://doaj.org/article/ac3f91e741e14ae68b947f045f6333f3
Autor:
Aline Cuenod, Jessica Agnetti, Helena Seth-Smith, Denise Waelchli, Dimitri Scherbakov, Rashid Akbergenov, Sarah Tschudin-Sutter, Stefano Bassetti, Martin Siegemund, Christian H. Nickel, Jacob Moran-Gilad, Timothy G. Keys, Valentin Pflueger, Nicholas R Thomson, Adrian Egli
Urinary tract infections are extremely common and often caused by Escherichia coli. Bacterial virulence factors and patient characteristics have been linked separately to progressive, invasive infection. The interaction of these factors has however r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d971bdb1bc411284e51d4d5791cacd75
https://doi.org/10.1101/2023.05.24.23290482
https://doi.org/10.1101/2023.05.24.23290482
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2183
The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures-polysaccharides, glycolipids, and glycoproteins. To raise a long-lasting and effective immune response against carbohydrate antigens, they generally re
Publikováno v:
Vaccine Delivery Technology ISBN: 9781071607947
The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures-polysaccharides, glycolipids, and glycoproteins. To raise a long-lasting and effective immune response against carbohydrate antigens, they generally re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a92a9631e59c4f9a66e0f531dd5e478
https://doi.org/10.1007/978-1-0716-0795-4_11
https://doi.org/10.1007/978-1-0716-0795-4_11
Autor:
Timothy G. Keys, Markus Aebi
Publikováno v:
Current Opinion in Systems Biology. 5:23-31
Controlling the specific glycan structure(s) present on a glycoprotein is a key challenge for both understanding its function and for developing effective next generation medical reagents. A decade ago the first engineered glycoproteins were produced
Autor:
Chris Meier, Mark Sutherland, Robert A. Falconer, Rita Gerardy-Schahn, Saskia Wolf, Jörg Ehrit, Timothy G. Keys
Publikováno v:
ChemBioChem. 18:1332-1337
α2,8-Linked polysialic acid (polySia) is an oncofoetal antigen with high abundance during embryonic development. It reappears in malignant tumours of neuroendocrine origin. Two polysialyltransferases (polySTs) ST8SiaII and IV are responsible for pol
Autor:
Martin F. Bachmann, Markus B. Tomek, Christoph Rutschmann, Yusuke Azuma, Naohiro Terasaka, Markus Aebi, Chia-Wei Lin, Donald Hilvert, Jacqueline Mock, Hanne L. P. Tytgat, Michael Wetter, Mikail D. Levasseur, Nora Liebscher, Timothy G. Keys
Publikováno v:
Nature Communications, 10 (1)
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Tytgat, Hanne L P; Lin, Chia-Wei; Levasseur, Mikail D; Tomek, Markus B; Rutschmann, Christoph; Mock, Jacqueline; Liebscher, Nora; Terasaka, Naohiro; Azuma, Yusuke; Wetter, Michael; Bachmann, Martin F.; Hilvert, Donald; Aebi, Markus; Keys, Timothy G (2019). Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies. Nature communications, 10(1), p. 5403. Springer Nature 10.1038/s41467-019-13283-2
Nature Communications 10 (2019) 1
Nature Communications, 10(1)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Tytgat, Hanne L P; Lin, Chia-Wei; Levasseur, Mikail D; Tomek, Markus B; Rutschmann, Christoph; Mock, Jacqueline; Liebscher, Nora; Terasaka, Naohiro; Azuma, Yusuke; Wetter, Michael; Bachmann, Martin F.; Hilvert, Donald; Aebi, Markus; Keys, Timothy G (2019). Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies. Nature communications, 10(1), p. 5403. Springer Nature 10.1038/s41467-019-13283-2
Nature Communications 10 (2019) 1
Nature Communications, 10(1)
Nature Communications
Glycosylation of proteins profoundly impacts their physical and biological properties. Yet our ability to engineer novel glycoprotein structures remains limited. Established bacterial glycoengineering platforms require secretion of the acceptor prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b83ff2af8fa8f17889cae3c4ac46b8e
https://hdl.handle.net/20.500.11850/383659
https://hdl.handle.net/20.500.11850/383659
Autor:
Angela Romanow, Rita Gerardy-Schahn, Friedrich Freiberger, Timothy G. Keys, Bernard Henrissat, Katharina Stummeyer
Publikováno v:
Journal of Biological Chemistry. 289:33945-33957
Crucial virulence determinants of disease causing Neisseria meningitidis species are their extracellular polysaccharide capsules. In the serogroups W and Y, these are heteropolymers of the repeating units (→6)-α-d-Gal-(1→4)-α-Neu5Ac-(2→)n in
Autor:
Manuela Mally, Ivan Hang, Jörg Schneider, Markus Aebi, Michael Wetter, Fabian Müller, Christoph Rutschmann, Simona Russo, Michael Steffen, Chia-Wei Lin, Matthias Zuppiger, Timothy G. Keys, Amirreza Faridmoayer
Publikováno v:
Metabolic Engineering, 44
Polysialic acid (polySia) is a posttranslational modification found on only a handful of proteins in the central nervous and immune systems. The addition of polySia to therapeutic proteins improves pharmacokinetics and reduces immunogenicity. To date