Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Timothy Friend Stanton"'
Autor:
Mirna Rodriguez, Timothy Friend Stanton, Frances Zhao, Eric Brian Sjogren, Taotao Wang, Jinfu Yang, Matthew I. Gross, Jim Li, Mark K. Bennett, Tania Chernov-Rogan, Julie Janes, Andrew L. Mackinnon, Susan Demo, Guy J. Laidig, Lijing Chen, Bindu Goyal, Francesco Parlati, Jennifer B. Dennison, Peter Shwonek, Evan R. Lewis
Publikováno v:
Molecular Cancer Therapeutics. 13:890-901
Glutamine serves as an important source of energy and building blocks for many tumor cells. The first step in glutamine utilization is its conversion to glutamate by the mitochondrial enzyme glutaminase. CB-839 is a potent, selective, and orally bioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2711514db56fc4c70085535c60e35c18
https://doi.org/10.1158/1535-7163.mct-13-0870
https://doi.org/10.1158/1535-7163.mct-13-0870
Autor:
Jamie Shields, Tina M. Woo, Kevin D. Shenk, Jinfu Yang, Catherine Sylvain, Congcong M. Sun, Francesco Parlati, Peter Shwonek, Evan R. Lewis, Jing Jiang, Eileen R. Ring, Guy J. Laidig, Timothy Friend Stanton, Mark K. Bennett, Monette Aujay, Tony Muchamuel, Maya Dajee, Han-Jie Zhou, Susan Demo, Ying Fang, Mark Nguyen Ho, Yan Lu, Christopher J. Kirk
Publikováno v:
Journal of Medicinal Chemistry. 52:3028-3038
Proteasome inhibition has been validated as a therapeutic modality in the treatment of multiple myeloma and non-Hodgkin's lymphoma. Carfilzomib, an epoxyketone currently undergoing clinical trials in malignant diseases, is a highly selective inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b068269960030e187ab3d9580dd312d
https://doi.org/10.1021/jm801329v
https://doi.org/10.1021/jm801329v
Autor:
Heinz E. Moser, Roland Burli, Kiet Truong, Yigong Ge, Alfred Chen, Timothy Friend Stanton, Wenhao Hu, Matthew I. Gross, Jacob Kaizerman, Sofia M. Touami, Vernon Jiang, Peter G. Jones, Mari Iwamoto, Kirk W. Johnson, Jian-Xin Duan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2067-2072
DNA binding ligands with potent antimicrobial activity against Gram-positive bacteria were further optimized by variation of the internal aromatic amino acids. This modification led to compounds with improved in vivo efficacy in lethal murine models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c0c07e0f36e16473735524315dc3a9
https://doi.org/10.1016/j.bmcl.2004.02.047
https://doi.org/10.1016/j.bmcl.2004.02.047
Autor:
Mark D. Matteucci, Zhijian Yang, Jian-Xin Duan, Timothy Friend Stanton, Hailong Jiao, Gustavo Lorente, Charles P. Hart, Monica Banica, Xiao-Ming Li, Robert M. Hoffman, Jacob Kaizerman, Jinwei Wang, James W. Evans, Leslie Lan, W. Steve Ammons, Don Jung, Huaiyu Ma
Publikováno v:
Journal of medicinal chemistry. 51(8)
A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA cross-linking toxin of the prodrug, ifosfamide. The hypoxia-selective cytotoxicity of several of the compounds was improved over previously reported racemic mixtu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6723ce4d2dc6246a4fbdee7903c25fc9
https://pubmed.ncbi.nlm.nih.gov/18257544
https://pubmed.ncbi.nlm.nih.gov/18257544