Výsledky vyhledávání - "Timothy Farren"

Data from CD126 and Targeted Therapy with Tocilizumab in Chronic Lymphocytic Leukemia

Autor: Samir G. Agrawal, Xishan Hao, Hong Li, Timothy Farren, Ping Wang, Li Jia, Feng-Ting Liu

Purpose: IL6 promotes tumor growth and signal transduction via both its membrane-bound (CD126) and soluble receptors (sCD126). We aimed to study whether the levels of CD126 expression in chronic lymphocytic leukemic (CLL) cells can predict in vitro a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16dcf2709f393c2f648d6fb795aa92a4
https://doi.org/10.1158/1078-0432.c.6524279

Zobrazit plný text záznamu

Supplementary Figures 1-6 from CD126 and Targeted Therapy with Tocilizumab in Chronic Lymphocytic Leukemia

Autor: Samir G. Agrawal, Xishan Hao, Hong Li, Timothy Farren, Ping Wang, Li Jia, Feng-Ting Liu

Figure S1: CD126 expression on CLL cells; S2: In vitro and in vivo chemoresponsiveness in CLL patients with 11q-/17p- and with higher or lower CD126 expression; S3: Correlation between CD126 expression and the sensitivity to Fludarabine-induced cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb1b13b909e3e5c25bee2c116edaf1a
https://doi.org/10.1158/1078-0432.22459667.v1

Zobrazit plný text záznamu

Increased autocrine interleukin‐6 production is significantly associated with worse clinical outcome in patients with chronic lymphocytic leukemia

Autor: Yu Ting Li, Timothy Farren, Feng Ting Liu, Samir G. Agrawal, Li Jia, Hua-Qing Wang

Publikováno v: Journal of Cellular Physiology

Chronic lymphocytic leukemia (CLL) remains incurable with current standard therapy. We have previously reported that an increased expression of interleukin‐6 (IL‐6) receptor CD126 leads to resistance of CLL cells to chemotherapy and worse prognos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6759140dcd3c515ca13f77e019e206
https://doi.org/10.1002/jcp.28086

Zobrazit plný text záznamu

Highly Sensitive and Accurate Assessment of Minimal Residual Disease in Chronic Lymphocytic Leukemia Using the Novel CD160-ROR1 Assay

Autor: Timothy Farren, Samir G. Agrawal, Kaushik S Sadanand

Publikováno v: Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)

Undetectable minimal residual disease (MRD) in Chronic Lymphocytic Leukemia (CLL) has a favorable prognostic outcome compared with MRD that can be detected. This study investigated a flow cytometric assay (CD160-ROR1FCA) targeting the tumor-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3eeda8c175c090d23eca1c1fdeff34a
https://pubmed.ncbi.nlm.nih.gov/33344247

Zobrazit plný text záznamu

Genomics and Diagnostics in Acute Myeloid Leukaemia

Autor: Ahad F. Al Seraihi, Ana Rio-Machin, Kiran Tawana, Sarah Charrot, Doriana Di Bella, Csaba Bödör, Tom Butler, Timothy Farren, Marianne Grantham, Jude Fitzgibbon

Publikováno v: Genomics and Clinical Diagnostics ISBN: 9781782628217

Cancers can be best described as genetic diseases, where mutations typically accumulate over a protracted period of time, leading to a cellular shift from normalcy to malignancy and an ever-evolving tumour and its microenvironment. The tools at our d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d80c2bec3d461a5022027d34bee1bcb
https://doi.org/10.1039/9781782628217-00161

Zobrazit plný text záznamu

STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia

Autor: Samir G. Agrawal, Hua-Qing Wang, Li Jia, Ping Wang, Timothy Farren, Feng Ting Liu

Publikováno v: Oncotarget

Chronic lymphocytic leukemia (CLL) is an adult disease characterized by in vivo accumulation of mature CD5/CD19/CD23 triple positive B cells and is currently incurable. CLL cells undergo spontaneous apoptosis in response to in vitro cell culture cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a252d57f8cccc143bfa792b39634f36c
https://doi.org/10.18632/oncotarget.8672

Zobrazit plný text záznamu

Frequency, demographics and risk (according to tumour type or site) of cancer-associated thrombosis among patients seen at outpatient DVT clinics

Autor: Derek Cooper, Anthea Nieland, Nicholas Scriven, Tim Nokes, Denise O'Shaughnessy, Harry Smith, Roopen Arya, Shankaranarayana Paneesha, Verity Investigators, Peter Rose, Aidan McManus, Timothy Farren, Sue Bacon

Publikováno v: Thrombosis and Haemostasis. 103:338-343

SummaryVenous thromboembolism (VTE) is a clinically important complication for both hospitalised and ambulatory cancer patients. In the current study, the frequency, demographics and risk (according to tumour site) of VTE were examined among patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a226d7d482208b9b42276a2989e3cda
https://doi.org/10.1160/th09-06-0397

Zobrazit plný text záznamu

Differential and tumor-specific expression of CD160 in B-cell malignancies

Autor: Dimitris A. Tsitsikas, John G. Gribben, Samir G. Agrawal, Armand Bensussan, Feng-Ting Liu, James D. Cavenagh, Timothy Farren, David Taussig, Adrian C. Newland, Jérôme Giustiniani, Heather Oakervee, Maria Calaminici, Marion G. Macey, Michael Jenner

CD160 is a human natural killer (NK)-cell–activating receptor that is also expressed on T-cell subsets. In the present study, we examined 811 consecutive cases of B-cell lymphoproliferative disorders (B-LPDs), and demonstrated CD160 expression in 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c25dca022250abafeb9953f1a16390
https://europepmc.org/articles/PMC5292591/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání