Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Timothy F. Osborne"'
Autor:
Eun-Ho Lee, Jae-Ho Lee, Do-Young Kim, Young-Seung Lee, Yunju Jo, Tam Dao, Kyung Eun Kim, Dae-Kyu Song, Ji Hae Seo, Young-Kyo Seo, Je Kyung Seong, Changjong Moon, Eugene Han, Mi Kyung Kim, Seungwan Ryu, Minsang Shin, Gu Seob Roh, Hye Ra Jung, Timothy F. Osborne, Dongryeol Ryu, Tae-Il Jeon, Seung-Soon Im
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 4, Pp 1001-1012 (2024)
Abstract Sterol regulatory element-binding protein (SREBP)-1c is involved in cellular lipid homeostasis and cholesterol biosynthesis and is highly increased in nonalcoholic steatohepatitis (NASH). However, the molecular mechanism by which SREBP-1c re
Externí odkaz:
https://doaj.org/article/80e78e3a38c74985adacee329525bee4
Autor:
Yu Muta, Juan F. Linares, Anxo Martinez-Ordoñez, Angeles Duran, Tania Cid-Diaz, Hiroto Kinoshita, Xiao Zhang, Qixiu Han, Yuki Nakanishi, Naoko Nakanishi, Thekla Cordes, Gurpreet K. Arora, Marc Ruiz-Martinez, Miguel Reina-Campos, Hiroaki Kasashima, Masakazu Yashiro, Kiyoshi Maeda, Ana Albaladejo-Gonzalez, Daniel Torres-Moreno, José García-Solano, Pablo Conesa-Zamora, Giorgio Inghirami, Christian M. Metallo, Timothy F. Osborne, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their po
Externí odkaz:
https://doaj.org/article/7936ce2ec8a04c66b79574c289fddb37
Autor:
Ryo Ito, Shiyu Xie, Myagmar Tumenjargal, Yuto Sugahara, Chaoran Yang, Hiroki Takahashi, Makoto Arai, Shin-Ichi Inoue, Aoi Uchida, Kenji Nakano, Hyunmi Choi, Ge Yang, Yanan Zhao, Rei Yamaguchi, Hitomi Jin, Hina Sagae, Youichiro Wada, Toshiya Tanaka, Hiroshi Kimura, Tatsuhiko Kodama, Hiroyuki Aburatani, Kazuhisa Takeda, Takeshi Inagaki, Timothy F. Osborne, Takeshi Yoneshiro, Yoshihiro Matsumura, Juro Sakai
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109398- (2024)
Summary: Mitochondria play a vital role in non-shivering thermogenesis in both brown and subcutaneous white adipose tissues (BAT and scWAT, respectively). However, specific regulatory mechanisms driving mitochondrial function in these tissues have be
Externí odkaz:
https://doaj.org/article/04a6729f65d1452297c0ef6f43b6e818
Autor:
Nityanand Bolshette, Saar Ezagouri, Vaishnavi Dandavate, Iuliia Karavaeva, Marina Golik, Hu Wang, Peter J Espenshade, Timothy F Osborne, Xianlin Han, Gad Asher
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002367 (2023)
In mammals, O2 and CO2 levels are tightly regulated and are altered under various pathological conditions. While the molecular mechanisms that participate in O2 sensing are well characterized, little is known regarding the signaling pathways that par
Externí odkaz:
https://doaj.org/article/94107980991d459cbfaa05c3857584f0
Autor:
Jae-Ho Lee, Sun Hee Lee, Eun-Ho Lee, Jeong-Yong Cho, Dae-Kyu Song, Young Jae Lee, Taeg Kyu Kwon, Byung-Chul Oh, Kae Won Cho, Timothy F. Osborne, Tae-Il Jeon, Seung-Soon Im
Publikováno v:
Journal of Advanced Research, Vol 45, Iss , Pp 1-13 (2023)
Introduction: Sterol regulatory element binding protein (SREBP) cleavage-associating protein (SCAP) is a sterol-regulated escort protein that translocates SREBPs from the endoplasmic reticulum to the Golgi apparatus, thereby activating lipid metaboli
Externí odkaz:
https://doaj.org/article/fa480bf32fcc444ab2cfb2d2d12b298f
Autor:
Yeong-Bin Baek, Hyung-Jun Kwon, Muhammad Sharif, Jeongah Lim, In-Chul Lee, Young Bae Ryu, Jae-In Lee, Ji-Sun Kim, Young-Seung Lee, Dong-Hoon Kim, Sang-Ik Park, Don-Kyu Kim, Jeong-Sun Kim, Hyon E. Choy, Sunwoo Lee, Hueng-Sik Choi, Timothy F. Osborne, Tae-Il Jeon, Kyoung-Oh Cho
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract The biosynthesis of host lipids and/or lipid droplets (LDs) has been studied extensively as a putative therapeutic target in diverse viral infections. However, directly targeting the LD lipolytic catabolism in virus-infected cells has not be
Externí odkaz:
https://doaj.org/article/48b91d4301c04a9aa8ecff65754a81e2
Autor:
Hiroki Takahashi, Ge Yang, Takeshi Yoneshiro, Yohei Abe, Ryo Ito, Chaoran Yang, Junna Nakazono, Mayumi Okamoto-Katsuyama, Aoi Uchida, Makoto Arai, Hitomi Jin, Hyunmi Choi, Myagmar Tumenjargal, Shiyu Xie, Ji Zhang, Hina Sagae, Yanan Zhao, Rei Yamaguchi, Yu Nomura, Yuichi Shimizu, Kaito Yamada, Satoshi Yasuda, Hiroshi Kimura, Toshiya Tanaka, Youichiro Wada, Tatsuhiko Kodama, Hiroyuki Aburatani, Min-Sheng Zhu, Takeshi Inagaki, Timothy F. Osborne, Takeshi Kawamura, Yasushi Ishihama, Yoshihiro Matsumura, Juro Sakai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How β-AR signaling coordinates epigenetic and transcriptional pathways is unknown. Here the authors show that cold-induced β-AR signaling negatively regulates MYPT1-PP1β phosphatase activity to orchestrate both pathways for beige adipogenesis.
Externí odkaz:
https://doaj.org/article/208e13262a3c409a916118bc6968d38e
Autor:
Edina Erdos, Katalin Sandor, Crystal L. Young-Erdos, Laszlo Halasz, Steven R. Smith, Timothy F. Osborne, Adeline Divoux
Publikováno v:
Cells, Vol 13, Iss 1, p 86 (2023)
Determining the mechanism driving body fat distribution will provide insights into obesity-related health risks. We used functional genomics tools to profile the epigenomic landscape to help infer the differential transcriptional potential of apple-
Externí odkaz:
https://doaj.org/article/986d819370ce4fa08fd33ece892becdc
Autor:
Laszlo Halasz, Adeline Divoux, Katalin Sandor, Edina Erdos, Bence Daniel, Steven R. Smith, Timothy F. Osborne
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 437 (2023)
The genome of human adipose-derived stem cells (ADSCs) from abdominal and gluteofemoral adipose tissue depots are maintained in depot-specific stable epigenetic conformations that influence cell-autonomous gene expression patterns and drive unique de
Externí odkaz:
https://doaj.org/article/e68b6e50da8a4b759f38e46de30fd0f7
Autor:
Yoshihiro Matsumura, Ryo Ito, Ayumu Yajima, Rei Yamaguchi, Toshiya Tanaka, Takeshi Kawamura, Kenta Magoori, Yohei Abe, Aoi Uchida, Takeshi Yoneshiro, Hiroyuki Hirakawa, Ji Zhang, Makoto Arai, Chaoran Yang, Ge Yang, Hiroki Takahashi, Hitomi Fujihashi, Ryo Nakaki, Shogo Yamamoto, Satoshi Ota, Shuichi Tsutsumi, Shin-ichi Inoue, Hiroshi Kimura, Youichiro Wada, Tatsuhiko Kodama, Takeshi Inagaki, Timothy F. Osborne, Hiroyuki Aburatani, Koichi Node, Juro Sakai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
How enhancers transition from a hypoacetylated primed state to a hyperacetylated-active state in response to differentiation stimuli is incompletely understood. Here the authors show that SETD5 forms a complex with NCoR-HDAC3 co-repressor to prevent
Externí odkaz:
https://doaj.org/article/2640437aeaa849649cfb58cee545c8e6