Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Timothy E. McGraw"'
Autor:
Maiko Matsui, Lauren E. Lynch, Isabella Distefano, Allison Galante, Aravind R. Gade, Hong-Gang Wang, Nicolas Gómez-Banoy, Patrick Towers, Daniel S. Sinden, Eric Q. Wei, Adam S. Barnett, Kenneth Johnson, Renan Lima, Alfonso Rubio-Navarro, Ang K. Li, Steven O. Marx, Timothy E. McGraw, Paul S. Thornton, Katherine W. Timothy, James C. Lo, Geoffrey S. Pitt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The canonical G406R mutation that increases Ca2+ influx through the CACNA1C-encoded CaV1.2 Ca2+ channel underlies the multisystem disorder Timothy syndrome (TS), characterized by life-threatening arrhythmias. Severe episodic hypoglycemia is
Externí odkaz:
https://doaj.org/article/c69ae191aabc414ca794e63e3df33805
Autor:
Nasser K. Altorki, Zachary H. Walsh, Johannes C. Melms, Jeffery L. Port, Benjamin E. Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J. Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J. Sanfilippo, Vivek Mittal, Alain C. Borczuk, Silvia C. Formenti, Benjamin Izar, Timothy E. McGraw
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract We previously reported the results of a randomized phase II trial (NCT02904954) in patients with early-stage non-small cell lung cancer (NSCLC) who were treated with either two preoperative cycles of the anti-PD-L1 antibody durvalumab alone
Externí odkaz:
https://doaj.org/article/9c53c31942514d7386ef3822fb6b7bc0
Autor:
Lucie Yammine, Belén Picatoste, Nazish Abdullah, Rosemary A. Leahey, Emma F. Johnson, Nicolás Gómez-Banoy, Carolina Rosselot, Jennifer Wen, Tahmina Hossain, Marcus D. Goncalves, James C. Lo, Adolfo Garcia-Ocaña, Timothy E. McGraw
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101831- (2023)
Objective: Glucose-dependent insulinotropic polypeptide (GIP) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor (GIPR) variant (Q354, rs1800437) is associated with a lower body mass index (BMI) and increased risk for Ty
Externí odkaz:
https://doaj.org/article/08e30cb16fb344d1bf22ff6b6349e352
Autor:
Anudari Letian, Eyoel Yemanaberhan Lemma, Paola Cavaliere, Noah Dephoure, Nasser K. Altorki, Timothy E. McGraw
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background PD-L1, a transmembrane ligand for immune checkpoint receptor PD1, has been successfully targeted to activate an anti-tumor immune response in a variety of solid tumors, including non-small cell lung cancer (NSCLC). Despite the suc
Externí odkaz:
https://doaj.org/article/71edcff8f7774d1ea09a38dadeeab3fd
Autor:
Ezequiel Dantas, Anirudh Murthy, Tanvir Ahmed, Mujmmail Ahmed, Shakti Ramsamooj, Maurice A. Hurd, Tiffany Lam, Murtaza Malbari, Christopher Agrusa, Olivier Elemento, Chen Zhang, Darryl J. Pappin, Timothy E. McGraw, Brendon M. Stiles, Nasser K. Altorki, Marcus D. Goncalves
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Background Lung cancer remains the major cause of cancer‐related deaths worldwide. Early stages of lung cancer are characterized by long asymptomatic periods that are ineffectively identified with the current screening programs. This defic
Externí odkaz:
https://doaj.org/article/9f3f0facc0d04731a5086808193bc9a9
Autor:
Michael J. P. Crowley, Bhavneet Bhinder, Geoffrey J. Markowitz, Mitchell Martin, Akanksha Verma, Tito A. Sandoval, Chang-Suk Chae, Shira Yomtoubian, Yang Hu, Sahil Chopra, Diamile A. Tavarez, Paolo Giovanelli, Dingcheng Gao, Timothy E. McGraw, Nasser K. Altorki, Olivier Elemento, Juan R. Cubillos-Ruiz, Vivek Mittal
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The IRE1α-XBP1 arm of the unfolded protein response (UPR) has been associated with immunosuppression and cancer progression. Here the authors show that IRE1α-XBP1 activation is associated with poor overall survival in patients with non-small cell l
Externí odkaz:
https://doaj.org/article/77b087499a044dd7be6eee31431dbce9
Autor:
Nasser K. Altorki, Zachary H. Walsh, Johannes C. Melms, Jeffery L. Port, Benjamin E. Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J. Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J. Sanfilippo, Vivek Mittal, Alain C. Borczuk, Silvia C. Formenti, Benjamin Izar, Timothy E. McGraw
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/52eb86e83ce04383a4f75d1460b549c4
Autor:
Nasser K. Altorki, Alain C. Borczuk, Sebron Harrison, Lauren K. Groner, Bhavneet Bhinder, Vivek Mittal, Olivier Elemento, Timothy E. McGraw
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110639- (2022)
Summary: To investigate changes in the tumor microenvironment (TME) during lung cancer progression, we interrogate tumors from two chest computed tomography (CT)-defined groups. Pure non-solid (pNS) CT density nodules contain preinvasive/minimally in
Externí odkaz:
https://doaj.org/article/173c102807e94bf980b2287099c20a2d
Autor:
Belén Picatoste, Lucie Yammine, Rosemary A. Leahey, David Soares, Emma F. Johnson, Paul Cohen, Timothy E. McGraw
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101305- (2021)
Objective: Recent studies indicate that brown adipose tissue, in addition to its role in thermogenesis, has a role in the regulation of whole-body metabolism. Here we characterize the metabolic effects of deleting Rab10, a protein key for insulin sti
Externí odkaz:
https://doaj.org/article/32bccb72a53e47c8941846dc4ef62228
Autor:
Archana Vijayakumar, Pratik Aryal, Jennifer Wen, Ismail Syed, Reema P. Vazirani, Pedro M. Moraes-Vieira, Joao Paulo Camporez, Molly R. Gallop, Rachel J. Perry, Odile D. Peroni, Gerald I. Shulman, Alan Saghatelian, Timothy E. McGraw, Barbara B. Kahn
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 1021-1035 (2017)
Summary: Lower adipose-ChREBP and de novo lipogenesis (DNL) are associated with insulin resistance in humans. Here, we generated adipose-specific ChREBP knockout (AdChREBP KO) mice with negligible sucrose-induced DNL in adipose tissue (AT). Chow-fed
Externí odkaz:
https://doaj.org/article/01014948a8b042bc958c1e6672bd5820