Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Timothy E. G. Krueger"'
Autor:
Tamara S. Rodems, Erika Heninger, Charlotte N. Stahlfeld, Cole S. Gilsdorf, Kristin N. Carlson, Madison R. Kircher, Anupama Singh, Timothy E. G. Krueger, David J. Beebe, David F. Jarrard, Douglas G. McNeel, Michael C. Haffner, Joshua M. Lang
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Loss of HLA-I gene expression in prostate cancer is associated with repressive chromatin states, which can be reversed by pharmacological DNMT and HDAC inhibition leading to increased activation of co-cultured tumor-specific CD8+ T-cells.
Externí odkaz:
https://doaj.org/article/1153e9cc0b6a481e85909d4a3f28af7d
Autor:
Timothy E. G. Krueger, Daniel L. J. Thorek, Samuel R. Denmeade, John T. Isaacs, W. Nathaniel Brennen
Publikováno v:
Stem Cells Translational Medicine, Vol 7, Iss 9, Pp 651-663 (2018)
Abstract The development of mesenchymal stem cells (MSCs) as cell‐based drug delivery vectors for numerous clinical indications, including cancer, has significant promise. However, a considerable challenge for effective translation of these approac
Externí odkaz:
https://doaj.org/article/7559fd62178645e6b65db7694242911c
Autor:
Zhongyuan Zhang, W. Nathaniel Brennen, Angelo M. De Marzo, Alexandria Brame, Levent Trabzonlu, Sarah R. Amend, Denis Wirtz, Timothy E. G. Krueger, Ashley Kiemen, Amber E. de Groot, Kayla V. Myers, Kenneth J. Pienta, Vicente E Torres, Natalia H Nagy
Publikováno v:
Prostate
Background Tumor-associated macrophages (TAMs) are critical components of the tumor microenvironment (TME) in prostate cancer. Commonly used orthotopic models do not accurately reflect the complete TME of a human patient or the natural initiation and
Autor:
Lizamma Antony, W. Nathaniel Brennen, Daniel L.J. Thorek, Samuel R. Denmeade, Timothy E. G. Krueger, Wen Jiang, John T. Isaacs
Publikováno v:
Immunotherapy
The tumor microenvironment contributes to disease progression through multiple mechanisms, including immune suppression mediated in part by fibroblast activation protein (FAP)-expressing cells. Herein, a review of FAP biology is presented, supplement
Autor:
Tamara S. Rodems, Erika Heninger, Charlotte N. Stahlfeld, Cole S. Gilsdorf, Kristin N. Carlson, Madison R. Kircher, Anupama Singh, Timothy E. G. Krueger, David J. Beebe, David F. Jarrard, Douglas G. McNeel, Michael C. Haffner, Joshua M. Lang
Publikováno v:
Communications biology. 5(1)
Downregulation of HLA class I (HLA-I) impairs immune recognition and surveillance in prostate cancer and may underlie the ineffectiveness of checkpoint blockade. However, the molecular mechanisms regulating HLA-I loss in prostate cancer have not been
Autor:
Daniel L.J. Thorek, Timothy E. G. Krueger, Samuel R. Denmeade, John T. Isaacs, W. Nathaniel Brennen
Publikováno v:
Stem Cells Translational Medicine, Vol 7, Iss 9, Pp 651-663 (2018)
Stem Cells Translational Medicine
Stem Cells Translational Medicine
The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for numerous clinical indications, including cancer, has significant promise. However, a considerable challenge for effective translation of these approaches is the
Autor:
Stephanie M. Thiede, Erika Heninger, Madison R. Kircher, David Kosoff, Timothy E. G. Krueger, Jamie M. Sperger, Brianna L. Byers, Joshua M. Lang, David F. Jarrard, Douglas G. McNeel, Bing Yang
Publikováno v:
Oncotarget
// Erika Heninger 1, 3 , Timothy E.G. Krueger 3 , Stephanie M. Thiede 1, 3 , Jamie M. Sperger 1, 3 , Brianna L. Byers 3 , Madison R. Kircher 3 , David Kosoff 1, 3 , Bing Yang 2, 3 , David F. Jarrard 2, 3 , Douglas G. McNeel 1, 3 , Joshua M. Lang 1, 3
Autor:
Timothy E. G. Krueger, Alan K. Meeker, John T. Isaacs, Daniel L.J. Thorek, W. Nathaniel Brennen
Publikováno v:
The Prostate. 79(3)
BACKGROUND: Prostate cancer is characterized by T-cell exclusion, which is consistent with their poor responses to immunotherapy. In addition, T-cells restricted to the adjacent stroma and benign areas are characterized by anergic and immunosuppressi
Publikováno v:
Immunotherapy. 5:1243-1254
The ability to evade host immune surveillance is critical for the survival of tumor cells and is correlated with poor clinical outcomes. Many tumor types have been found to downregulate expression of genes involved in antigen production, processing a
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Frontiers in Immunology
Frontiers in Immunology
Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that occurs in the process of tumorigenesis. This phenomena impacts antigen processing and antigen presentation by tumor cells and facilitates evasion of immunosu