Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Timothy E. Cullingford"'
Autor:
Andrew K Marshall, Oliver P T Barrett, Timothy E Cullingford, Achchuthan Shanmugasundram, Peter H Sugden, Angela Clerk
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10027 (2010)
Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g. endothelin-1)] regulate gene expression and are implicated in the response
Externí odkaz:
https://doaj.org/article/a5f889d6a8db46e181196577e51151c9
Publikováno v:
Advances in Enzyme Regulation. 49:30-42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2fc823241f97f69ebca635b0bc1eb0
https://doi.org/10.1016/j.advenzreg.2008.12.007
https://doi.org/10.1016/j.advenzreg.2008.12.007
Autor:
Angela Clerk, Timothy M. Cannell, Mario Petrou, Sanjay K Prasad, Timothy J. Kemp, Alexander W.Y. Chen, Martin R. Cowie, Timothy E. Cullingford
Publikováno v:
European Journal of Heart Failure. 10:1177-1180
A greater understanding of the molecular basis of hibernating myocardium may assist in identifying those patients who would most benefit from revascularization. Paired heart biopsies were taken from hypocontractile and normally-contracting myocardium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779543ecc1a1a2025dafe0d5880aa276
https://doi.org/10.1016/j.ejheart.2008.08.008
https://doi.org/10.1016/j.ejheart.2008.08.008
Autor:
Stephen J. Fuller, Hauke Cornils, El Li Tham, Timothy E. Cullingford, Sampsa Pikkarainen, Jeffery D. Molkentin, Angela Clerk, Brian A. Hemmings, Alexander Hergovich, Peter H. Sugden
Publikováno v:
Cellular Signalling. 20:1564-1577
The nuclear Dbf2-related protein kinases 1 and 2 (NDR1/2) are closely-related AGC family kinases that are strongly conserved through evolution. In mammals, they are activated inter alia by phosphorylation of an hydrophobic domain threonine-residue [N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e164ea1fbc6e054ff0b079302c6a180b
https://doi.org/10.1016/j.cellsig.2008.04.013
https://doi.org/10.1016/j.cellsig.2008.04.013
Publikováno v:
Advances in Enzyme Regulation. 45:94-111
Considerable efforts have been expended in elucidating the inter-cellular and intra-cellular signaling pathways which elicit cardiac myocyte hypertrophy or apoptosis, and in identifying the changes which are associated with the end-stage of the respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8e76fb54ffdc4c2badb2f8fd89cd55
https://doi.org/10.1016/j.advenzreg.2005.02.007
https://doi.org/10.1016/j.advenzreg.2005.02.007
Autor:
Angela Clerk, Andrew K. Marshall, Peter H. Sugden, Timothy E. Cullingford, El Li Tham, Thomais Markou
Publikováno v:
BMC Genomics
BMC Genomics, Vol 11, Iss 1, p 343 (2010)
BMC Genomics, Vol 11, Iss 1, p 343 (2010)
Background Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6452a61291c1c88184ebd573bdb45a7
https://pubmed.ncbi.nlm.nih.gov/20509958
https://pubmed.ncbi.nlm.nih.gov/20509958
Autor:
Thomais Markou, Ali Alsafi, Timothy E. Cullingford, Alejandro Giraldo, Sophie C. Weiss, Peter H. Sugden, Angela Clerk, Stephen J. Fuller
Inhibition of glycogen synthase kinase 3beta (GSK3beta) as a consequence of its phosphorylation by protein kinase B/Akt (PKB/Akt) has been implicated in cardiac myocyte hypertrophy in response to endothelin-1 or phenylephrine. We examined the regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9466eb81b8bef209578a3503d5d0b842
https://centaur.reading.ac.uk/18419/1/GSK3_Cell_Signal.pdf
https://centaur.reading.ac.uk/18419/1/GSK3_Cell_Signal.pdf
Autor:
Angela Clerk, Joanne G Harrison, Donna M. Valks, Timothy E. Cullingford, Mika Jormakka, Sharon M. Cole
Publikováno v:
Pharmacologytherapeutics. 97(3)
Cardiac myocyte death, whether through necrotic or apoptotic mechanisms, is a contributing factor to many cardiac pathologies. Although necrosis and apoptosis are the widely accepted forms of cell death, they may utilize the same cell death machinery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cffae524f0afd659b53763ee5944e5f
https://pubmed.ncbi.nlm.nih.gov/12576135
https://pubmed.ncbi.nlm.nih.gov/12576135
Autor:
Daniel J. Beckett, Robert L. Smith, Azara Janmohamed, Ian Phillips, Timothy E. Cullingford, Elizabeth A. Shephard, Colin T. Dolphin
Publikováno v:
The Journal of biological chemistry. 273(46)
Flavin-containing monooxygenases (FMOs) are NADPH-dependent flavoenzymes that catalyze the oxidation of heteroatom centers in numerous drugs and xenobiotics. FMO2, or “pulmonary” FMO, one of five forms of the enzyme identified in mammals, is expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b300fe1121a7193a5a4c96392062ae0
https://pubmed.ncbi.nlm.nih.gov/9804831
https://pubmed.ncbi.nlm.nih.gov/9804831
Autor:
Oliver P. T. Barrett, Andrew K. Marshall, Angela Clerk, Timothy E. Cullingford, Achchuthan Shanmugasundram, Peter H. Sugden
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 4, p e10027 (2010)
PLoS ONE, Vol 5, Iss 4, p e10027 (2010)
BACKGROUND Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g. endothelin-1)] regulate gene expression and are implicated in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da425b9e1b3a50e06ccca16f7e15f917
https://doi.org/10.1371/journal.pone.0010027
https://doi.org/10.1371/journal.pone.0010027