Výsledky vyhledávání - "Timothy E. Bates"

Akademický článek

Co-inhibition of BCL-XL and MCL-1 with selective BCL-2 family inhibitors enhances cytotoxicity of cervical cancer cell lines

Autor: Siti Fairus Abdul Rahman, Kalaivani Muniandy, Yong Kit Soo, Elvin Yu Huai Tiew, Ke Xin Tan, Timothy E. Bates, Nethia Mohana-Kumaran

Publikováno v: Biochemistry and Biophysics Reports, Vol 22, Iss , Pp - (2020)

Development of resistance to chemo- and radiotherapy in patients suffering from advanced cervical cancer narrows the therapeutic window for conventional therapies. Previously we reported that a combination of the selective BCL-2 family inhibitors ABT

Externí odkaz: https://doaj.org/article/fd5c805d67fa48279d5e625a83065301

Zobrazit plný text záznamu

Akademický článek

Delayed Treatment with α-Phenyl-N-tert-butyl Nitrone (PBN) Attenuates Secondary Mitochondrial Dysfunction after Transient Focal Cerebral Ischemia in the Rat

Autor: Satoshi Kuroda, Ken-ichiro Katsura, Lars Hillered, Timothy E. Bates, Bo K. Siesjö

Publikováno v: Neurobiology of Disease, Vol 3, Iss 2, Pp 149-157 (1996)

The present experiments were undertaken to explore the mechanisms of secondary brain damage in focal ischemia of long duration (2 h), followed by recirculation. Recirculation has previously been found to cause partial recovery and secondary deteriora

Externí odkaz: https://doaj.org/article/c29edb58bb2f4ed58f9de2506d19afdc

Zobrazit plný text záznamu

Co-inhibition of BCL-XL and MCL-1 with selective BCL-2 family inhibitors enhances cytotoxicity of cervical cancer cell lines

Autor: Elvin Yu Huai Tiew, Kalaivani Muniandy, Ke Xin Tan, Nethia Mohana-Kumaran, Timothy E. Bates, Siti Fairus Abdul Rahman, Yong Kit Soo

Publikováno v: Biochemistry and Biophysics Reports, Vol 22, Iss, Pp-(2020)
Biochemistry and Biophysics Reports

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21989a9d11ce79ea0b21b4da5ceda5de
https://doi.org/10.1016/j.bbrep.2020.100756

Zobrazit plný text záznamu

Anti-angiogenic drugs: direct anti-cancer agents with mitochondrial mechanisms of action

Autor: Tammy Wiltshire, Lewis A. Quayle, Gerjan Scheper, Ria E. Peake, Maria G. Pereira, Carol Rea, Timothy E. Bates, Issam Hussain

Publikováno v: Oncotarget

Components of the mitochondrial electron transport chain have recently gained much interest as potential therapeutic targets. Since mitochondria are essential for the supply of energy that is required for both angiogenic and tumourigenic activity, ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c503d656154b39a327ae64da0241374b
https://pubmed.ncbi.nlm.nih.gov/29179466

Zobrazit plný text záznamu

The Effects of Antidepressants on Mitochondrial Function in a Model Cell System and Isolated Mitochondria

Autor: Timothy E. Bates, David A. Kendall, W. Abdel-Razaq

Publikováno v: Neurochemical Research. 36:327-338

The in vitro effects of antidepressant drugs on mitochondrial function were investigated in a CHOβ(2)SPAP cell line used previously to determine the effects of antidepressants on gene transcription (Abdel-Razaq et al., Biochem Pharmacol 73:1995-2003

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8511955b6f1aaacb5b5e35d354dae9bc
https://doi.org/10.1007/s11064-010-0331-z

Zobrazit plný text záznamu

Tricyclic antidepressants and the incidence of certain cancers: a study using the GPRD

Autor: Alex J Walker, Timothy R. Card, Kenneth Muir, Timothy E. Bates

Publikováno v: British Journal of Cancer

Background: Several studies suggest links between cancer and tricyclic antidepressant use. Methods: A case–control study using the General Practice Research Database examined whether previous tricyclic usage was associated with reduced incidence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3f50e8b4b06921ea3f6d5e59a0fb0f
https://doi.org/10.1038/sj.bjc.6605996

Zobrazit plný text záznamu

Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels

Autor: Ivan Rattray, David A. Barrett, Sarir Sarmad, Charles A. Marsden, Gillian A. Scullion, James Lowe, Marie-Christine Pardon, Timothy E. Bates, David A. Kendall

Publikováno v: Neurobiology of Aging. 30:1099-1113

Environmental factors (e.g. stress, exercise, enrichment) are thought to play a role in the development of Alzheimer's disease later in life. We investigated the influence of repeated novel cage exposure on the development of early Alzheimer's-like p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20456b97d63a617915376c26e772d70
https://doi.org/10.1016/j.neurobiolaging.2007.10.002

Zobrazit plný text záznamu

Characteristics of the Calcium-Triggered Mitochondrial Permeability Transition in Nonsynaptic Brain Mitochondria

Autor: Timothy E. Bates, Tibor Kristian, Jeffrey H. Gertsch, Bo K. Siesjö

Publikováno v: Journal of Neurochemistry. 74:1999-2009

The objective of the present study was to assess the capacity of nonsynaptic brain mitochondria to accumulate Ca2+ when subjected to repeated Ca2+ loads, and to explore under what conditions a mitochondrial permeability transition (MPT) pore is assem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64c514476d2e0a6a6e2cf1096fa2546e
https://doi.org/10.1046/j.1471-4159.2000.0741999.x

Zobrazit plný text záznamu

Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity

Autor: Anna Maria Giuffrida Stella, Timothy E. Bates, Albena T Dinkova Kostova, Carolin Cornelius, Vittorio Calabrese, Cesare Mancuso, Francesco Bellia, Enrico Rizzarelli, Tony Schapira, Giovanni Pennisi, Stella Calafato

Publikováno v: Neurochemical research 33 (2008): 2444–2471. doi:10.1007/s11064-008-9775-9
info:cnr-pdr/source/autori:Rizzarelli, Enrico (1); Bellia, Francesco (1); Mancuso, Cesare (3); Calabrese, Vittorio (1); Cornelius, Carolin (1); Calafato, Stella (4); Giuffrida Stella, Anna Maria (1); Pennisi, Giovanni (2); Schapira, Tony (4); Bates, Timothy E. (5); Dinkova Kostova, Albena T. (7)/titolo:Cellular stress response: A novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity/doi:10.1007%2Fs11064-008-9775-9/rivista:Neurochemical research/anno:2008/pagina_da:2444/pagina_a:2471/intervallo_pagine:2444–2471/volume:33

The predominant molecular symptom of aging is the accumulation of altered gene products. Moreover, several conditions including protein, lipid or glucose oxidation disrupt redox homeostasis and lead to accumulation of unfolded or misfolded proteins i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61e196b2b582912bdb96d1b13fcd14b
https://doi.org/10.1007/s11064-008-9775-9

Zobrazit plný text záznamu

Protection of Respiratory Chain Enzymes from Ischaemic Damage in Adult Rat Brain Slices

Autor: Iain P. Hargreaves, K Brooks, Timothy E. Bates

Publikováno v: Neurochemical Research. 33:1711-1716

The effect of aglycaemic hypoxia (AH) on the activity of the mitochondrial respiratory chain complexes was measured in superfused adult cortical brain slices. After 15 min of AH the activity of complex II-III was significantly reduced (by 45%) with n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f62c0dde927751f9ef715f7ff12a6e
https://doi.org/10.1007/s11064-008-9609-9

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání