Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Timothy E Sweeney"'
Autor:
Steven L Raymond, María Cecilia López, Henry V Baker, Shawn D Larson, Philip A Efron, Timothy E Sweeney, Purvesh Khatri, Lyle L Moldawer, James L Wynn
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184159 (2017)
Sepsis is a major cause of morbidity and mortality, especially at the extremes of age. To understand the human age-specific transcriptomic response to sepsis, a multi-cohort, pooled analysis was conducted on adults, children, infants, and neonates wi
Externí odkaz:
https://doaj.org/article/96358a27d07b4d0daa06eb06cfd3829a
Autor:
Timothy E Sweeney, Hagir B Suliman, John W Hollingsworth, Karen E Welty-Wolf, Claude A Piantadosi
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25249 (2011)
Activation of the host antibacterial defenses by the toll-like receptors (TLR) also selectively activates energy-sensing and metabolic pathways, but the mechanisms are poorly understood. This includes the metabolic and mitochondrial biogenesis master
Externí odkaz:
https://doaj.org/article/81c62789aeda430ab7335cd319989d47
Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis.
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11606 (2010)
The PGC family of transcriptional co-activators (PGC-1alpha [Ppargc1a], PGC-1beta [Ppargc1b], and PRC [Pprc]) coordinates the upregulation of mitochondrial biogenesis, and Ppargc1a is known to be activated in response to mitochondrial damage in sepsi
Externí odkaz:
https://doaj.org/article/17fde4beaaed4030bb7366faf735b245
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background Viral acute respiratory illnesses (viral ARIs) contribute significantly to human morbidity and mortality worldwide, but their successful treatment requires timely diagnosis of viral etiology, which is complicated by overlap in cli
Externí odkaz:
https://doaj.org/article/e35765f48c964693b946ba09ce295eec
Autor:
Jeremy A. Balch, Uan-I Chen, Oliver Liesenfeld, Petr Starostik, Tyler J. Loftus, Philip A. Efron, Scott C. Brakenridge, Timothy E. Sweeney, Lyle L. Moldawer
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may lead to targeted interventions. We investigated whether patients admit
Externí odkaz:
https://doaj.org/article/ebd16a5d714d405c8c683d468eb7bc5b
Autor:
Khushbu Patel, Susan Evans, Jong Lee, Vamsee Pamula, Ajay Shah, Timothy E Sweeney, Amogha Tadimety
Publikováno v:
Clinical Chemistry. 69:216-221
Publikováno v:
Diagnostics, Vol 11, Iss 10, p 1902 (2021)
Background: Anti-TNF-alpha (anti-TNFα) therapies have transformed the care and management of inflammatory bowel disease (IBD). However, they are expensive and ineffective in greater than 50% of patients, and they increase the risk of infections, liv
Externí odkaz:
https://doaj.org/article/a498898ce8464721910278b24ed947c8
Autor:
Antigone, Kostaki, James W, Wacker, Asimina, Safarika, Nicky, Solomonidi, Konstantinos, Katsaros, George, Giannikopoulos, Ioannis M, Koutelidakis, Catherine A, Hogan, Florian, Uhle, Oliver, Liesenfeld, Timothy E, Sweeney, Evangelos J, Giamarellos-Bourboulis
Publikováno v:
Shock. 58:224-230
Background: Risk stratification of emergency department patients with suspected acute infections and/or suspected sepsis remains challenging. We prospectively validated a 29-messenger RNA host response classifier for predicting severity in these pati
Autor:
Paul N. Newton, Pruksa Nawtaisong, Anisone Chanthongthip, David A. Relman, Sanjana Gupta, Isaac I. Bogoch, Jason R. Andrews, Manivanh Vongsouvath, Viengmon Davong, Matthew T. Robinson, Simone A. Thair, Krista Vaidya, Sabine Dittrich, Stephen J. Popper, Mayfong Maxay, Purvesh Khatri, Aditya M Rao, Timothy E. Sweeney, Biraj Man Karmacharya
Background: Early and accurate diagnosis of acute infection has important consequences for antibiotic stewardship, resource allocation, and clinical outcomes. However, limited sensitivity and specificity of current diagnostics lead to the erroneous p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe6402c1231ed347e1994c5181129d6
https://ora.ox.ac.uk/objects/uuid:8f605e8f-8a47-442a-9367-60eabdd5f14e
https://ora.ox.ac.uk/objects/uuid:8f605e8f-8a47-442a-9367-60eabdd5f14e
Autor:
Noa Galtung, Eva Diehl-Wiesenecker, Dana Lehmann, Natallia Markmann, Wilma H. Bergström, James Wacker, Oliver Liesenfeld, Michael Mayhew, Ljubomir Buturovic, Roland Luethy, Timothy E. Sweeney, Rudolf Tauber, Kai Kappert, Rajan Somasundaram, Wolfgang Bauer
Publikováno v:
European Journal of Emergency Medicine. 29:357-365
mRNA-based host response signatures have been reported to improve sepsis diagnostics. Meanwhile, prognostic markers for the rapid and accurate prediction of severity in patients with suspected acute infections and sepsis remain an unmet need. IMX-SEV