Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Timothy E Saunders"'
Publikováno v:
eLife, Vol 12 (2024)
Microtubule asters are essential in localizing the action of microtubules in processes including mitosis and organelle positioning. In large cells, such as the one-cell sea urchin embryo, aster dynamics are dominated by hydrodynamic pulling forces. H
Externí odkaz:
https://doaj.org/article/16d5864055d14e339889fb08d48da9b4
Publikováno v:
eLife, Vol 11 (2022)
In a previous study, it was reported that Yap1 and Wwtr1 in zebrafish regulates the morphogenesis of the posterior body and epidermal fin fold (Kimelman et al., 2017). We report here that DNA damage induces apoptosis of epidermal basal cells (EBCs) i
Externí odkaz:
https://doaj.org/article/bcb4509d67614ed3ae48cc8580f4faa5
Publikováno v:
eLife, Vol 9 (2020)
During development, many mutations cause increased variation in phenotypic outcomes, a phenomenon termed decanalization. Phenotypic discordance is often observed in the absence of genetic and environmental variations, but the mechanisms underlying su
Externí odkaz:
https://doaj.org/article/1ae721d9700f4fa2aaaee4c349ec0766
Autor:
Lucia Durrieu, Daniel Kirrmaier, Tatjana Schneidt, Ilia Kats, Sarada Raghavan, Lars Hufnagel, Timothy E Saunders, Michael Knop
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 9, Pp 1-15 (2018)
Abstract Embryogenesis relies on instructions provided by spatially organized signaling molecules known as morphogens. Understanding the principles behind morphogen distribution and how cells interpret locally this information remains a major challen
Externí odkaz:
https://doaj.org/article/2c0ade67e83342f8a757a66bdf98e136
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 3, p e1006039 (2018)
Quantitative reasoning and techniques are increasingly ubiquitous across the life sciences. However, new graduate researchers with a biology background are often not equipped with the skills that are required to utilize such techniques correctly and
Externí odkaz:
https://doaj.org/article/80daa5248d2d4de1b286ad1de3fe44bc
Publikováno v:
eLife, Vol 6 (2017)
Morphogen gradients provide essential spatial information during development. Not only the local concentration but also duration of morphogen exposure is critical for correct cell fate decisions. Yet, how and when cells temporally integrate signals f
Externí odkaz:
https://doaj.org/article/a147b0a654c24b83a02cae01e22dc05e
Publikováno v:
eLife, Vol 3 (2014)
Cells can, in principle, control their size by growing to a specified size before commencing cell division. How any cell actually senses its own size remains poorly understood. The fission yeast Schizosaccharomyces pombe are rod-shaped cells that gro
Externí odkaz:
https://doaj.org/article/e8f1e6869e37427883ab8bf52f728ebc
Autor:
Jelena Erceg, Timothy E Saunders, Charles Girardot, Damien P Devos, Lars Hufnagel, Eileen E M Furlong
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004060 (2014)
Deciphering the specific contribution of individual motifs within cis-regulatory modules (CRMs) is crucial to understanding how gene expression is regulated and how this process is affected by sequence variation. But despite vast improvements in the
Externí odkaz:
https://doaj.org/article/d597279fba374fe1a304bf8e004529e1
Autor:
Shaobo Zhang, Timothy E. Saunders
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100817- (2021)
Summary: How individual cells form precise connections with partners in a complicated environment has been a longstanding question. However, most cell matching studies have used qualitative approaches, which may miss subtle but significant morphologi
Externí odkaz:
https://doaj.org/article/cd01daad95df48b1b7ec0c8a6ed4821d
Microtubule asters are essential in localizing the action of microtubules in processes including mitosis and organelle positioning. In large cells, such as the one-cell sea urchin embryo, aster dynamics are dominated by hydrodynamic pulling forces. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::c17eb8bddc24f4ec6cfd2867017c64e8
https://zenodo.org/record/8090780
https://zenodo.org/record/8090780
