Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Timothy E Graham"'
Publikováno v:
Laboratory Medicine. 54:327-332
Monogenetic diabetes mellitus (DM) describes a collection of single-gene diseases marked by hyperglycemia presenting in childhood or adulthood and the absence of immunological markers of type 1 DM. Mutations in the human insulin gene INS give rise to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bcb10771e36fed8d2391858c5498f8
https://doi.org/10.1093/labmed/lmac115
https://doi.org/10.1093/labmed/lmac115
Autor:
Jinjin Cai, Karla M. Pires, Maroua Ferhat, Bhagirath Chaurasia, Márcio A. Buffolo, Rana Smalling, Ashot Sargsyan, Donald L. Atkinson, Scott A. Summers, Timothy E. Graham, Sihem Boudina
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1708-1717.e5 (2018)
Summary: Autophagy is a homeostatic cellular process involved in the degradation of long-lived or damaged cellular components. The role of autophagy in adipogenesis is well recognized, but its role in mature adipocyte function is largely unknown. We
Externí odkaz:
https://doaj.org/article/1964fc4db6104ef3a7b9a2e4940e3468
Autor:
Mark Cadena, Quincy Eckert Harenda, Michelle E. Kimple, Harpreet K. Brar, Erin Laundre, Jaclyn A. Wisinski, Haley Wienkes, Rachel J. Fenske, Feyza Engin, Kathryn A. Carbajal, Jinjin Cai, Allison L. Brill, Timothy E. Graham, Michael D. Schaid, Nathan A. Truchan
Publikováno v:
Endocrinology. 158:1645-1658
The α-subunit of the heterotrimeric Gz protein, Gαz, promotes β-cell death and inhibits β-cell replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that loss of Gαz protein would preserve functional β-cell mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e38097c30271c3b225bcbcfa7ad6d26
https://doi.org/10.1210/en.2016-1700
https://doi.org/10.1210/en.2016-1700
Autor:
Jason J. Yuen, Jinjin Cai, Seung-Ah Lee, Manuel Mark, Ashot Sargsyan, Norbert B. Ghyselinck, Rana Smalling, Spencer J Thompson, Timothy E. Graham, William S. Blaner
Publikováno v:
Diabetes
Diabetes, 2017, 66 (1), pp.58-63. ⟨10.2337/db16-0286⟩
Diabetes, 2017, 66 (1), pp.58-63. ⟨10.2337/db16-0286⟩
RBP4 is produced mainly by hepatocytes. In type 2 diabetes and obesity, circulating RBP4 is increased and may act systemically to cause insulin resistance and glucose intolerance. Observations that adipocyte RBP4 mRNA increases in parallel with circu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083453db126a4ad7c1cff18b89467a78
https://hal.science/hal-03677801
https://hal.science/hal-03677801
Autor:
Sihem Boudina, Timothy E. Graham
Publikováno v:
Experimental Physiology. 99:1168-1178
The role of mitochondria in white adipocytes has long been neglected due in part to their lower abundance in these cells. However, accumulating evidence suggests that mitochondria are vital for maintaining metabolic homeostasis in white adipocytes be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a994bed2291a2e181d0fe11297d95583
https://doi.org/10.1113/expphysiol.2014.081414
https://doi.org/10.1113/expphysiol.2014.081414
Autor:
Christopher Yeager, Christopher C. Shoemaker, Nathaniel P. Clancy, Timothy E. Graham, Erin M. Lehmer, Kathryn Lavengood, Hannah L. Price, Shane Michael Kersten, Sherry A. Paddock
Publikováno v:
BIOS. 85:38-47
Sin Nombre virus (SNV) is a hantavirus hosted almost exclusively by deer mice (Peromyscus maniculatus) that causes high (∼40%) mortality in humans. Transmission patterns of SNV in natural host populations are not well understood and, as such, repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54552261d9e520579b54c4fa2fbd3982
https://doi.org/10.1893/0005-3155-85.1.38
https://doi.org/10.1893/0005-3155-85.1.38
Autor:
Seul Ki Park, Van Reese, Ting Ruan, Timothy E. Graham, Youyou Li, David D. Symons, Sihem Boudina, Jae Min Cho, Russel S. Richardson, Pon Velayutham Anandh Babu, Ashot Sargsyan, Leena P. Bharath, Robert A. Mueller, Tyler Bean, Jinjin Cai, Karla Maria Pereira Pires
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 37(9)
Objective— Impaired endothelial cell (EC) autophagy compromises shear stress–induced nitric oxide (NO) generation. We determined the responsible mechanism. Approach and Results— On autophagy compromise in bovine aortic ECs exposed to shear stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8c0e75332453aef19133c86b9e4b66
https://pubmed.ncbi.nlm.nih.gov/28684613
https://pubmed.ncbi.nlm.nih.gov/28684613
Shifts between on and off states of the Atlantic Meridional Overturning Circulation (AMOC) have been associated with past abrupt climate change, supported by the bistability of the AMOC found in many older, coarser resolution, ocean and climate model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec17fc2a14ce5db15c9b8650a44b6b14
https://eprints.soton.ac.uk/402320/
https://eprints.soton.ac.uk/402320/
Autor:
Iratxe Eskurza, Qin Yang, Barbara B. Kahn, Urban A. Kiernan, Matthias Blüher, Timothy E. Graham, David A. Phillips
Publikováno v:
Endocrinology. 153:1519-1527
Serum retinol-binding protein 4 (RBP4) levels are increased in insulin-resistant humans and correlate with severity of insulin resistance in metabolic syndrome. Quantitative Western blotting (qWestern) has been the most accurate method for serum RBP4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f805e4e56079ad7513324f60a6166a0
https://doi.org/10.1210/en.2011-1750
https://doi.org/10.1210/en.2011-1750
Autor:
Timothy E. Graham, Scott A. Summers, Bhagirath Chaurasia, Jinjin Cai, Ashot Sargsyan, Karla Maria Pereira Pires, Sihem Boudina, Ma´rcio A. Buffolo, Maroua Ferhat, Rana Smalling, Donald L. Atkinson
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1708-1717.e5 (2018)
Summary: Autophagy is a homeostatic cellular process involved in the degradation of long-lived or damaged cellular components. The role of autophagy in adipogenesis is well recognized, but its role in mature adipocyte function is largely unknown. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d123342b2eb8d8e9bba58bdf54c8d9bc
https://doi.org/10.1016/j.celrep.2018.10.040
https://doi.org/10.1016/j.celrep.2018.10.040