Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Timothy E, O'Toole"'
Autor:
Alok R Amraotkar, David Hoetker, Mohammad J Negahdar, Chin K Ng, Pawel Lorkiewicz, Ugochukwu S Owolabi, Shahid P Baba, Aruni Bhatnagar, Timothy E O'Toole
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299872 (2024)
Carnosine is an endogenous di-peptide (β-alanine -L- histidine) involved in maintaining tissue homeostasis. It is most abundant in skeletal muscle where its concentration has been determined in biopsy samples using tandem mass spectrometry (MS-MS).
Externí odkaz:
https://doaj.org/article/537067f086124cf69b941847bf937b1f
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Background High-throughput RNA sequencing (RNA-seq) has evolved as an important analytical tool in molecular biology. Although the utility and importance of this technique have grown, uncertainties regarding the proper analysis of RNA-seq da
Externí odkaz:
https://doaj.org/article/5211d3632bae457abe93c3e8b6f179bd
Autor:
Jingjing Zhao, Daniel Gomes, Lexiao Jin, Steven P. Mathis, Xiaohong Li, Eric C. Rouchka, Haribabu Bodduluri, Daniel J. Conklin, Timothy E. O’Toole
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 232, Iss , Pp 113239- (2022)
Vast amounts of plastic materials are produced in the modern world and despite recycling efforts, large amounts are disposed in water systems and landfills. Under these storage conditions, physical weathering and photochemical processes break down th
Externí odkaz:
https://doaj.org/article/b180ca31c080472a906cac1d01bb9f86
Autor:
Petra Haberzettl, Lexiao Jin, Daniel W. Riggs, Jingjing Zhao, Timothy E. O’Toole, Daniel J. Conklin
Publikováno v:
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Abstract Exposure to fine particulate matter (PM2.5) air pollution increases blood pressure, induces vascular inflammation and dysfunction, and augments atherosclerosis in humans and rodents; however, the understanding of early changes that foster ch
Externí odkaz:
https://doaj.org/article/bbacb423d55c4ce290b50415863baa41
Autor:
Jordan Finch, Daniel W. Riggs, Timothy E. O’Toole, C. Arden Pope III, Aruni Bhatnagar, Daniel J. Conklin
Publikováno v:
AIMS Environmental Science, Vol 6, Iss 4, Pp 265-276 (2019)
Acute and chronic exposures to particulate matter (PM2.5) air pollution increase the risk for cardiovascular disease (CVD). A hypothesized mechanism linking PM2.5 exposure and CVD is the induction of endothelial dysfunction – a key step to increase
Externí odkaz:
https://doaj.org/article/c572b869b37b4289b3b5bb55411c8c21
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 13 (2019)
Background Exposure to fine airborne particulate matter (PM 2.5) induces quantitative and qualitative defects in bone marrow–derived endothelial progenitor cells of mice, and similar outcomes in humans may contribute to vascular dysfunction and the
Externí odkaz:
https://doaj.org/article/eef9e6a4b7da46aaa733ba192629f0b6
Autor:
Ray Yeager, Daniel W. Riggs, Natasha DeJarnett, David J. Tollerud, Jeffrey Wilson, Daniel J. Conklin, Timothy E. O'Toole, James McCracken, Pawel Lorkiewicz, Zhengzhi Xie, Nagma Zafar, Sathya S. Krishnasamy, Sanjay Srivastava, Jordan Finch, Rachel J. Keith, Andrew DeFilippis, Shesh N. Rai, Gilbert Liu, Aruni Bhatnagar
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 24 (2018)
Background Exposure to green vegetation has been linked to positive health, but the pathophysiological processes affected by exposure to vegetation remain unclear. To study the relationship between greenness and cardiovascular disease, we examined th
Externí odkaz:
https://doaj.org/article/f0397ebecfef4105b14a041fb1949fd6
Autor:
Nagma Zafar, Sathya S Krishnasamy, Jasmit Shah, Shesh N Rai, Daniel W Riggs, Aruni Bhatnagar, Timothy E O'Toole
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205851 (2018)
Circulating angiogenic cells (CACs) of various described phenotypes participate in the regeneration of the damaged endothelium, but the abundance of these cells is highly influenced by external cues including diabetes. It is not entirely clear which
Externí odkaz:
https://doaj.org/article/404f63b07ec7420bab13b90a48a70456
Autor:
Xiaohong Li, Eric C Rouchka, Guy N Brock, Jun Yan, Timothy E O'Toole, David A Tieri, Nigel G F Cooper
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201813 (2018)
Breast cancer (BC) is increasing in incidence and resistance to treatment worldwide. The challenges in limited therapeutic options and poor survival outcomes in BC subtypes persist because of its molecular heterogeneity and resistance to standard end
Externí odkaz:
https://doaj.org/article/97566553d6bd4255b00c581fde6a0e99
Autor:
Xiaohong Li, Guy N Brock, Eric C Rouchka, Nigel G F Cooper, Dongfeng Wu, Timothy E O'Toole, Ryan S Gill, Abdallah M Eteleeb, Liz O'Brien, Shesh N Rai
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176185 (2017)
Normalization is an essential step with considerable impact on high-throughput RNA sequencing (RNA-seq) data analysis. Although there are numerous methods for read count normalization, it remains a challenge to choose an optimal method due to multipl
Externí odkaz:
https://doaj.org/article/a8a395924fac4d30ad6a7991f554b336