Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Timothy D. Westfall"'
Autor:
Timothy D. Westfall, Céline Rouget, Pascal Rischmann, Stefano Palea, Philippe Lluel, Philippe Camparo, Moez Rekik, Henri Botto
Publikováno v:
European Journal of Pharmacology. 690:202-206
Fenoterol has been reported to be a potent and selective β2-adrenoceptor agonist and is currently used clinically to treat asthma. Electrical field stimulation (EFS) of isolated urinary bladder mimics the voiding contraction by stimulating parasympa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55206245590df23345de3c670cd76ffb
https://doi.org/10.1016/j.ejphar.2012.06.036
https://doi.org/10.1016/j.ejphar.2012.06.036
Publikováno v:
European Journal of Pharmacology. 618:76-83
beta(3)-adrenoceptor activation produces relaxation of human urinary bladder smooth muscle (detrusor). Therefore, beta(3)-adrenoceptor agonism is being investigated as a new therapeutic strategy for the treatment of overactive bladder. The aim of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4255f90fe39e3ca2e82f01e089f65a
https://doi.org/10.1016/j.ejphar.2009.07.012
https://doi.org/10.1016/j.ejphar.2009.07.012
Autor:
Timothy D. Westfall, Chris P. Doe, Shufang Zhao, Ross G. Bentley, Alan R. Olzinski, Robert W. Coatney, Marianne E. Eybye, Kristeen Maniscalco, Robert N. Willette, Nambi Aiyar, David J. Behm
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 330:964-970
The evidence is compelling for a role of inflammation in cardiovascular diseases; however, the chronic use of anti-inflammatory drugs for these indications has been disappointing. The recent study compares the effects of two anti-inflammatory agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4afb6033e6cd0e7c28aaf30d94e8b7
https://doi.org/10.1124/jpet.109.154443
https://doi.org/10.1124/jpet.109.154443
Autor:
Earl Gordon, David P. Brooks, Timothy D. Westfall, Erin S. R. Lashinger, Bartholomew J. Votta, Blake A. Misajet, Linda N. Casillas, Robert W. Marquis, Gerald P. McCafferty, Josephine H.L. Nation, David J. Figueroa, Tim P. Chendrimada, Louise C Evans, Douglas J. DeMarini, Anthony Sulpizio, Zuojun Lin, Angela K. Clouse, Kevin S. Thorneloe, Nicholas J. Laping, Xiaoping Xu, Steven A. Sheardown
Publikováno v:
Scopus-Elsevier
The transient receptor potential (TRP) vanilloid 4 (TRPV4) member of the TRP superfamily has recently been implicated in numerous physiological processes. In this study, we describe a small molecule TRPV4 channel activator, ( N -((1 S )-1-{[4-((2 S )
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d26d906fa78708a003171b1058374c
https://doi.org/10.1124/jpet.108.139295
https://doi.org/10.1124/jpet.108.139295
Autor:
Charlene Wu, Shaila S. Shabbir, Pat M. Woollard, Alan D. Borthwick, Simon Peace, Fabrizio Nerozzi, David E. Davies, Timothy D. Westfall, John Liddle, Wendy R. Irving, Deirdre Mary Bernadette Hickey, Joanne Philp, Christopher Charles Frederick Hamlett, Derek Pollard, Mark Pullen, David P. Brooks, Gerald P. McCafferty, Richard M. Edwards, Andrew M. Mason, Steve L. Sollis, Michael Allen, Anne M. Exall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:90-94
Optimisation of a series of oxazole diketopiperazines has led to the discovery of a very potent and selective oxytocin antagonist GSK221149A. GSK221149A has been shown to inhibit oxytocin-induced uterine contractions in the anaesthetised rat.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7169b86c2410cd3ad98037d3bf0d45c4
https://doi.org/10.1016/j.bmcl.2007.11.008
https://doi.org/10.1016/j.bmcl.2007.11.008
Autor:
Erin S. Riedel, Christopher P. Evans, Gerald P. McCafferty, Gian C Rivera, Nambi Aiyar, Robert W. Coatney, Trudy D Luce, Timothy D. Westfall, Mark Pullen, J. Paul Hieble, Alexandra Hicks
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 323:202-209
Functional studies have demonstrated that adrenoceptor agonist-evoked relaxation is mediated primarily by beta3-adrenergic receptors (ARs) in human bladder. Thus, the use of selective beta3-AR agonists in the pharmacological treatment of overactive b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17cdfb1ca21c612e6d9888dac476f51
https://doi.org/10.1124/jpet.107.125757
https://doi.org/10.1124/jpet.107.125757
Autor:
Pascal Rischmann, Timothy D. Westfall, Philippe Camparo, Moez Rekik, Stewart W. McCallum, Céline Rouget, Henry Botto, Stefano Palea, Philippe Lluel
Publikováno v:
Journal of Urology. 193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec8c8b8496bb7f36ed7b3f24c3c3728e
https://doi.org/10.1016/j.juro.2015.02.1358
https://doi.org/10.1016/j.juro.2015.02.1358
Publikováno v:
British Journal of Pharmacology. 138:757-766
(1) The involvement of Rho-kinase (ROCK) in the contractile mechanisms mediating smooth muscle contraction of the rat urinary bladder was investigated using expression studies and the ROCK inhibitor Y-27632. (2) Both isoforms of ROCK (ROCK I and ROCK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a05793211b2ad87ff28991072764892
https://doi.org/10.1038/sj.bjp.0705109
https://doi.org/10.1038/sj.bjp.0705109
Autor:
R Liberman, David P. Westfall, Peter Sneddon, N Ramphir, J R W Menzies, Timothy D. Westfall, Charles Kennedy, S Waterston
Publikováno v:
British Journal of Pharmacology. 131:909-914
The properties of the ATPase released during electrical field stimulation (EFS) (8 Hz, 25 s) of the sympathetic nerves of the superfused rabbit isolated vas deferens were investigated. Superfusate collected during EFS rapidly metabolised exogenous AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::573f2928379a69e793a8929d45fb545d
https://doi.org/10.1038/sj.bjp.0703662
https://doi.org/10.1038/sj.bjp.0703662
Publikováno v:
British Journal of Pharmacology. 129:1684-1688
The release of ATPase activity evoked by electrical field stimulation (EFS) (8 Hz, 25 s) was investigated in several tissues in which adenosine 5′-triphosphate (ATP) acts as a neurotransmitter. Superfusate collected during EFS of sympathetic nerves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74e20c076b27b31d143a0e04591b746a
https://doi.org/10.1038/sj.bjp.0703271
https://doi.org/10.1038/sj.bjp.0703271