Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Timothy D. Warner"'
Autor:
Ami Vadgama, James Boot, Nicola Dark, Harriet E. Allan, Charles A. Mein, Paul C. Armstrong, Timothy D. Warner
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 5, Pp 102523- (2024)
Background: Platelet function is driven by the expression of specialized surface markers. The concept of distinct circulating subpopulations of platelets has emerged in recent years, but their exact nature remains debatable. Objectives: To design a s
Externí odkaz:
https://doaj.org/article/8ec091d9bcdb4e8381e3ad21edd45326
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Research into the natural aging process of platelets has garnered much research interest in recent years, and there have long been associations drawn between the proportion of newly formed platelets in the circulation and the risk of thrombosis. Howe
Externí odkaz:
https://doaj.org/article/a07bef35f153430baceb089435b11e4e
Autor:
Ambra Cappelletto, Harriet E. Allan, Marilena Crescente, Edoardo Schneider, Rossana Bussani, Hashim Ali, Ilaria Secco, Simone Vodret, Roberto Simeone, Luca Mascaretti, Serena Zacchigna, Timothy D. Warner, Mauro Giacca
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2023)
Thrombosis of the lung microvasculature is a characteristic of COVID-19 disease, which is observed in large excess compared to other forms of acute respiratory distress syndrome and thus suggests a trigger for thrombosis that is endogenous to the lun
Externí odkaz:
https://doaj.org/article/4d9c6b235b4c46048734a1b26cae79e3
Autor:
Melissa V. Chan, Melissa A. Hayman, Suthesh Sivapalaratnam, Marilena Crescente, Harriet E. Allan, Matthew L. Edin, Darryl C. Zeldin, Ginger L. Milne, Jonathan Stephens, Daniel Greene, Moghees Hanif, Valerie B. O'Donnell, Liang Dong, Michael G. Malkowski, Claire Lentaigne, Katherine Wedderburn, Matthew Stubbs, Kate Downes, Willem H. Ouwehand, Ernest Turro, NIHR BioResource, Daniel P. Hart, Kathleen Freson, Michael A. Laffan, Timothy D. Warner
Publikováno v:
Haematologica, Vol 106, Iss 5 (2020)
We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 in PTGS1 (the gene encoding cyclo-oxygenase 1, COX-1, the target of anti-thrombotic aspirin therapy). We report that in the homozygous state within a l
Externí odkaz:
https://doaj.org/article/67d8336da71a4f9fa0252ac3ddc88ca1
Publikováno v:
Platelets, Vol 29, Iss 7, Pp 686-689 (2018)
In this short article, submitted as part of the review on platelet function testing, we illustrate the quantitative and qualitative differences between classical light transmission aggregometry (LTA) and 96-well plate aggregometry. We show that respo
Externí odkaz:
https://doaj.org/article/84c977599e23402ea3e4b2f850012f77
Publikováno v:
Platelets, Vol 29, Iss 7, Pp 650-655 (2018)
While there are many bench and bedside tests to assess platelet reactivity, ex vivo light transmission aggregometry (LTA) remains the gold standard. LTA, however, is expensive, time-consuming and requires dedicated equipment and staff, making it impr
Externí odkaz:
https://doaj.org/article/e6b552c6264f4ba4aedf70f1a543d310
Autor:
Rebecca B. Knowles, Matthew J. Lawrence, Plinio M. Ferreira, Melissa A. Hayman, Lindsay A. D’Silva, Sophie N. Stanford, Ahmed Sabra, Arthur T. Tucker, Karl M. Hawkins, Phylip R. Williams, Timothy D. Warner, Phillip A. Evans
Publikováno v:
Platelets, Vol 29, Iss 2, Pp 162-170 (2018)
Despite the interwoven nature of platelet activation and the coagulation system in thrombosis, few studies relate both analysis of protein and cellular parts of coagulation in the same population. In the present study, we use matched ex vivo samples
Externí odkaz:
https://doaj.org/article/305d318329e04f2a8626aaf53c2fd6c1
Autor:
Hannah Hsu, Melissa V. Chan, Paul C. Armstrong, Marilena Crescente, Dea Donikian, Mayuko Kondo, Timothy Brighton, Vivien Chen, Qiang Chen, David Connor, Joanne Joseph, Marie-Christine Morel-Kopp, William S. Stevenson, Christopher Ward, Timothy D. Warner, David J. Rabbolini
Publikováno v:
Pathology. 54:746-754
Identification of disordered platelet function is important to guide peri-operative bleeding management as well as long term treatment and prognostic strategies in individuals with platelet bleeding disorders. Light transmission aggregometry (LTA), t
Autor:
David Bishop-Bailey, Timothy D. Warner, Desmond T. Walsh, Robert Carpenter, Márta Korbonits, Karen E. Swales
Bile acids are present at high concentrations in breast cysts and in the plasma of postmenopausal women with breast cancer. The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that regulates bile acid homeostasis. FXR was d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b2d40e87ff0db7666e2e4d56380513
https://doi.org/10.1158/0008-5472.c.6494070
https://doi.org/10.1158/0008-5472.c.6494070
Autor:
David Bishop-Bailey, Timothy D. Warner, Desmond T. Walsh, Robert Carpenter, Márta Korbonits, Karen E. Swales
Supplementary Figures 1-4 from The Farnesoid X Receptor Is Expressed in Breast Cancer and Regulates Apoptosis and Aromatase Expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7665d61760ae181bda0c8f60095a1103
https://doi.org/10.1158/0008-5472.22364202.v1
https://doi.org/10.1158/0008-5472.22364202.v1