Zobrazeno 1 - 10
of 563
pro vyhledávání: '"Timothy D. Veenstra"'
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1513 (2023)
Huntington’s Disease (HD) is a severely debilitating neurodegenerative disorder in which sufferers exhibit different combinations of movement disorders, dementia, and behavioral or psychiatric abnormalities. The disorder is a result of a trinucleot
Externí odkaz:
https://doaj.org/article/0f12de5ea86a44e3b81849e2a1d2a1d5
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 96 (2023)
The relatively recent developments in mass spectrometry (MS) have provided novel opportunities for this technology to impact modern medicine. One of those opportunities is in biomarker discovery and diagnostics. Key developments in sample preparation
Externí odkaz:
https://doaj.org/article/5da3364f990942868942697f38cf1b95
Autor:
Wei Tang, Ming Zhou, Tiffany H. Dorsey, DaRue A. Prieto, Xin W. Wang, Eytan Ruppin, Timothy D. Veenstra, Stefan Ambs
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-14 (2018)
Abstract Background Transcriptome analysis of breast cancer discovered distinct disease subtypes of clinical significance. However, it remains a challenge to define disease biology solely based on gene expression because tumor biology is often the re
Externí odkaz:
https://doaj.org/article/3eae996b1f73443095d4e08a8cb9995d
Autor:
Joseph Paul, Timothy D. Veenstra
Publikováno v:
Separations, Vol 9, Iss 4, p 89 (2022)
There are probably no biological samples that did more to spur interest in proteomics than serum and plasma. The belief was that comparing the proteomes of these samples obtained from healthy and disease-affected individuals would lead to biomarkers
Externí odkaz:
https://doaj.org/article/ee8c2771014742939844cc5167e35430
Autor:
Xiaojun Xia, Shuang Liu, Zuoxiang Xiao, Feng Zhu, Na-Young Song, Ming Zhou, Bigang Liu, Jianjun Shen, Kunio Nagashima, Timothy D. Veenstra, Sandra Burkett, Mahesh Datla, Jami Willette-Brown, Haifa Shen, Yinling Hu
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1243-1255 (2013)
The inflammatory microenvironment promotes skin tumorigenesis. However, the mechanisms by which cells protect themselves from inflammatory signals are unknown. Downregulation of IKKα promotes skin tumor progression from papillomas to squamous cell c
Externí odkaz:
https://doaj.org/article/82c7880764134d168b07a3bf8eeda293
Autor:
Papa M. Drame, Zhaojing Meng, Sasisekhar Bennuru, Jesica A. Herrick, Timothy D. Veenstra, Thomas B. Nutman
Publikováno v:
mBio, Vol 7, Iss 1 (2016)
ABSTRACT Immunoassays are currently needed to quantify Loa loa microfilariae (mf). To address this need, we have conducted proteomic and bioinformatic analyses of proteins present in the urine of a Loa mf-infected patient and used this information to
Externí odkaz:
https://doaj.org/article/85a2e55e0d4c4d7e9c2b4b8de7c856f4
Autor:
Joseph W. Briggs, Ling Ren, Rachel Nguyen, Kristi Chakrabarti, Jessica Cassavaugh, Said Rahim, Gulay Bulut, Ming Zhou, Timothy D. Veenstra, Qingrong Chen, Jun S. Wei, Javed Khan, Aykut Uren, Chand Khanna
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 4, Pp 297-310 (2012)
We previously associated the cytoskeleton linker protein, Ezrin, with the metastatic phenotype of pediatric sarcomas, including osteosarcoma and rhabdomyosarcoma. These studies have suggested that Ezrin contributes to the survival of cancer cells aft
Externí odkaz:
https://doaj.org/article/8e7ac71289f543b79be9f4bbfc7dfee5
Autor:
Timothy Waybright, William K. Gillette, Dominic Esposito, Robert M. Stephens, David A. Lucas, James L. Hartley, Timothy D. Veenstra
Publikováno v:
BioTechniques, Vol 45, Iss 3, Pp 307-315 (2008)
This article describes an improved pooled open reading frame (ORF) expression technology (POET) that uses recombinational cloning and solution-based tandem mass spectrometry (MS/MS) to identify ORFs that yield high levels of soluble, purified protein
Externí odkaz:
https://doaj.org/article/83b7559ac3a54d6bba46460b5f92964c
Autor:
Ming Zhou, Timothy D. Veenstra
Publikováno v:
BioTechniques, Vol 44, Iss 5, Pp 667-670 (2008)
While definitely not a new technology, mass spectrometry (MS) has seen incredible growth over the past 25 years. Mass spectrometry has rapidly evolved to the forefront of analytical techniques; its ability to analyze proteins is the major driving for
Externí odkaz:
https://doaj.org/article/0c81a51d6f0d46eebacff02e8a9835f1
Autor:
Haleem J. Issaq, Timothy D. Veenstra
Publikováno v:
BioTechniques, Vol 44, Iss 5, Pp 697-700 (2008)
The recent trend in science is to assay as many biological molecules as possible within a single experiment. This trend is evident in proteomics where the aim is to characterize thousands of proteins within cells, tissues, and organisms. While advanc
Externí odkaz:
https://doaj.org/article/d9cce465e6e745a0a234158d44ad4fe0