Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Timothy D. Spitzer"'
Publikováno v:
Journal of Heterocyclic Chemistry. 50:863-867
An imidazolidinone intermediate (3) used in the synthesis of novel HIV-entry inhibitors was prepared on multihundred gram scales in four steps and 40% overall yield. The penultimate step in the synthesis involved regioselective N-cyclization of N-(2-
Publikováno v:
Magnetic Resonance in Chemistry. 46:558-563
We describe here new versions of the DEPT phase-encoded HMQC experiment that offer robust performance and improved sensitivity. The new sequences rely on frequency-swept proton and carbon pulses to minimize signal losses from miscalibrated pulses whi
Publikováno v:
Magnetic Resonance in Chemistry. 46:564-570
This article describes new versions of the DEPT phase-edited heteronuclear single quantum correlation (HSQC) pulse sequence with sensitivity enhancement. The sequences incorporate frequency-swept carbon and proton pulses. The new experiments are inhe
Autor:
Randy D. Rutkowske, Sergey S. Golotvin, Antony J. Williams, Timothy D. Spitzer, Brent A. Lefebvre, Rostislav Pol, Eugene Vodopianov
Publikováno v:
Magnetic Resonance in Chemistry. 45:803-813
A method for structure validation based on the simultaneous analysis of a 1D 1H NMR and 2D 1H13C single-bond correlation spectrum such as HSQC or HMQC is presented here. When compared with the validation of a structure by a 1D 1H NMR spectrum alone,
Autor:
Eugene Vodopianov, Antony J. Williams, Sergey S. Golotvin, Timothy D. Spitzer, Brent A. Lefebvre
Publikováno v:
Magnetic Resonance in Chemistry. 44:524-538
A unique opportunity exists when an experimental NMR spectrum is obtained for which a specific chemical structure is anticipated. A process of Verification—the confirmation of a postulated structure—is now possible, as opposed to Elucidation—th
Autor:
Andrea M. Sefler, Timothy D. Spitzer, Edgar R. Wood, O. Bradley McDonald, Bryan R. Reep, Eric E. Boros, James B. Thompson
Publikováno v:
Journal of Heterocyclic Chemistry. 41:355-358
5-Methoxy and 5-anilinopyrido[2,3-d]pyrimidin-7(8H)-ones 2a-2f were obtained by a tandem Michael addition-cyclization reaction of methanol and anilines with pyrimidinylpropynoate 5. Methoxy derivative 2a was obtained in 62% yield by treatment of 5 wi
Autor:
John J. Savarese, Douglas L. Cohn, Vicente Samano, Paul L. Feldman, Michael McNulty, Timothy D. Spitzer, William B. Wastila, Robert A. Mook, Patel Sanjay Shashikant, Eric E. Boros, Mir Hashim, Matthew R. Belmont, Jan-Ake I. Schultz, Philip F. Morgan
Publikováno v:
Anesthesiology. 100:835-845
Background No replacement for succinylcholine is yet available. GW280430A (AV430A) is a representative of a new class of nondepolarizing neuromuscular blocking drugs called asymmetric mixed-onium chlorofumarates. It undergoes rapid degradation in pla
Autor:
Peter Kitrinos, Edward P. Garvey, Zhihong Xu, Timothy D. Spitzer, Octerloney B. McDonald, Masayoshi Oyama, Rosie R.J. Jones, Kuo Hsiung Lee
Publikováno v:
Letters in Drug Design & Discovery. 1:24-29
A novel undecylresorcinol dimer ( 1 ) was isolated from Coleophoma sp. andinhibited cFMS receptor tyrosine kinase (IC 50 of 0.4 µM), with greater than 10-foldselectivity versus nine other protein kinases. The known fungal metabolites balanoland alte
Publikováno v:
Magnetic Resonance in Chemistry. 39:539-543
Two new pulse sequences are presented for the acquisition of DEPT–HMQC spectra, based on the original experiment of Kessler et al. The new sequences employ modifications intended to make the experiment well suited for high-throughput acquisition an
Autor:
Gary E. Martin, John P. Shockcor, Daniel W. Reynolds, Robert L. Johnson, Robert W. Morrison, Timothy D. Spitzer, Ronald C. Crouch
Publikováno v:
Journal of Heterocyclic Chemistry. 32:1255-1259
During the development of the bis-indole alkaloid anticancer drug Navelbine® (vinorelbine), several chemical degradants of the drug were isolated and identified. These included 7′-nor-6′,9′-secovinorelbine (7′,8′-bisnor-6′,9′-secoanhyd