Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Timothy D. Ocain"'
1
NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ
Autor: Serkan Ismail Göktuna, Nico van Rooijen, Roland M. Schmid, Melek C. Arkan, Jason Goode, Justus Duyster, Michael Neuenhahn, Florian R. Greten, Joshua Fierer, Stephan Paxian, Bruce Jaffee, Michael Karin, Cornelius Miething, Julia Bollrath, Timothy D. Ocain, Yajun Xu, Li-Chung Hsu, Dirk H. Busch, Lars Eckmann
Publikováno v: Cell. 130(5):918-931
IKKbeta-dependent NF-kappaB activation plays a key role in innate immunity and inflammation, and inhibition of IKKbeta has been considered as a likely anti-inflammatory therapy. Surprisingly, however, mice with a targeted IKKbeta deletion in myeloid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28b8d92069a40fbed53bf182719335e
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2
Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8
Autor: Mingshi Dai, Swanee Jacutin-Porte, Wei Yin, Charles A. Minor, Shan Huang, Tracy J. Jenkins, Weirong Chen, Gang Li, Thomas E. Lightburn, Daniel Cardillo, Matthew Jones, Shomir Ghosh, Douglas F. Burdi, Christopher Blackburn, Robert Bennett, Roland Kolbeck, Sean Smith, B. Scott Freeze, Timothy D. Ocain, Geraldine C Harriman, Kenneth M. Gigstad, Bing Guan
Publikováno v: Journal of Medicinal Chemistry. 50:566-584
The design, synthesis, and structure-activity relationship development of naphthalene-derived human CCR8 antagonists is described. In vitro binding assay results of these investigations are reported, critical interactions of the antagonists with CCR8
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ece8a43fb824560f99d9d32c158515
https://doi.org/10.1021/jm061118e
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3
Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop
Autor: Bruce Jaffee, Ping Li, Anlai Wang, Yajun Xu, Terri Addona, Zhi Li, Timothy D. Ocain, Hong Cheng, Hasmik Keshishian, Thomas F. Parsons, Chafen Lu, Marion Dorsch, Erik Dahlstrand
Publikováno v: Biochemical and Biophysical Research Communications. 352:609-616
Interleukin-1 stimulation leads to the recruitment of MyD88, interleukin-1 receptor-associated kinase 1 (IRAK-1) and interleukin-1 receptor-associated kinase 4 (IRAK-4) to the IL-1 receptor. The formation of the IL-1 receptor complex triggers a serie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793b267f9ab3585051d7b6197d7ae84a
https://doi.org/10.1016/j.bbrc.2006.11.068
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4
Quantitation of peripheral blood markers of rat experimental autoimmune encephalomyelitis
Autor: Timothy D. Ocain, Russell M. Walker, Michael Fitzgerald, Aileen Healy, Elena S. Izmailova, Bruce Jaffee
Publikováno v: Autoimmunity. 40:355-365
Identification and quantitation of peripheral blood non-invasive, cell-surface markers of EAE disease activity and drug response would facilitate the preclinical development of potential therapeutics. Towards this end, we characterized the influx of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc99ca7b93b7ef9659add5e6bc484457
https://doi.org/10.1080/08916930701391579
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5
In vitro immunomodulatory activity of ruthenium complexes
Autor: J. C. Jenson, Paul G. Gregory, K. A. Gordon, B. Rivnay, M Jesson, J. R. Newcomb, S. M. Turci, J. Krieger, B. Jones, C. M. Bastos, Timothy D. Ocain, K. A. Sterne
Publikováno v: Inflammation Research. 52:263-271
Objective and Design: We have explored the in vitro immunomodulatory effects of pure ruthenium red and a series of pyridine and imidazole substituted ruthenium complexes (RCs). Material: Human peripheral blood lymphocytes and purified T cells were us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe299ce2e6bcfc081fb9cccd5de1014
https://doi.org/10.1007/s00011-003-1169-5
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6
Novel Small-Molecule Inhibitors of RNA Polymerase III
Autor: Deborah R. Wysong, Tony Wood, Patrick R. Errada, Tanya Parkinson, Karen J. McGovern, Ian M. Willis, Ronald K. Blackman, Liping Wu, Alexandra E. Gould, Vala Thoroddsen, Timothy D. Ocain, Daniel Kornitzer, Lawrence R. Dick, Patrick Dorr, Christine E. Bulawa, Jing Pan, Ziva Weissman
Publikováno v: Eukaryotic Cell. 2:256-264
A genetic approach utilizing the yeast Saccharomyces cerevisiae was used to identify the target of antifungal compounds. This analysis led to the identification of small molecule inhibitors of RNA polymerase (Pol) III from Saccharomyces cerevisiae .
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea39b926c7746449d970b5756a2e85ca
https://doi.org/10.1128/ec.2.2.256-264.2003
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7
T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection
Autor: Emiko Mizoguchi, Timothy D. Ocain, Linda K. Clayton, Yoseph Ghendler, Vishva M. Dixit, Kim Orth, Raymond J. Patch, Atul K. Bhan, Ellis L. Reinherz
Publikováno v: The EMBO Journal. 16:2282-2293
T-cell receptors (TCRs) are created by a stochastic gene rearrangement process during thymocyte development, generating thymocytes bearing useful, as well as unwanted, specificities. Within the latter group, autoreactive thymocytes arise which are su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204c563ad0b6e70ec188cbcbb467c965
https://doi.org/10.1093/emboj/16.9.2282
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8
Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma
Autor: Martin R. Hodge, Mingshi Dai, Wei Yin, Roland Kolbeck, Timothy D. Ocain, Jacqueline C. Pulido, Elise LaMantia-Martin, Lin Wang, Tracy J. Jenkins
Publikováno v: Thorax. 68(6)
Background Expression of the T-cell-associated chemokine receptor CCR8 and its ligand CCL1 have been demonstrated to be elevated in patients with asthma. CCR8 deficiency or inhibition in models of allergic airway disease in mice resulted in conflicti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbad04498d5663c87372f014a56821e
https://pubmed.ncbi.nlm.nih.gov/23457038
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9
Conformational sensitivity analysis of FKBP-FK506/rapamycin complexes
Autor: Roberta Susnow, Nancie A. Senko, Timothy D. Ocain
Publikováno v: Journal of Computational Chemistry. 15:1074-1090
Sensitivity analysis techniques are applied to the FKBP–FK506 and FKBP–rapamycin complexes to quantify the conformational relationships between FKBP and its ligands. Crystal structures of the two FKBP complexes are energy minimized in the Amber f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e8a46a293b5104f4d7b37151dabfe54
https://doi.org/10.1002/jcc.540151004
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