Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Timothy D. Heath"'
Autor:
Timothy D. Heath, Robert J. Debs, Stephen Chmura, Alice Ye, Chakkrapong Handumrongkul, Sarah Ursu, Ron G. Rosenfeld
Publikováno v:
Journal of the Endocrine Society. 5:A550-A551
Recombinant human growth hormone (rhGH), the mainstay of hGH replacement therapy, is injected daily for years to enable children to achieve normal stature. Daily rhGH injections are required because its serum-T1/2 is 230 days; 2) Concurrently, hGH-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37da55879d29133f557f4549052e10ff
https://doi.org/10.1210/jendso/bvab048.1121
https://doi.org/10.1210/jendso/bvab048.1121
Autor:
Stephen Chmura, Yong Liu, Ryan J Ice, David B. Lewis, Liliana Soroceanu, Alice L. Ye, Robert Thistle, Denny Liggitt, Methawee Myers, Chakkrapong Handumrongkul, Mohammed Kashani-Sabet, Robert J. Debs, Sarah Ursu, Marissa Mack, Timothy D. Heath
Publikováno v:
Science Advances
HEDGES, a tunable nonviral DNA-based gene therapy platform, durably expresses human therapeutic proteins in immunocompetent mice.
Recombinant adeno-associated virus (AAV) vectors are transforming therapies for rare human monogenic deficiency dis
Recombinant adeno-associated virus (AAV) vectors are transforming therapies for rare human monogenic deficiency dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a82e7e5a17981e499fb82dac6a28dd
https://pubmed.ncbi.nlm.nih.gov/31807699
https://pubmed.ncbi.nlm.nih.gov/31807699
Autor:
Timothy D. Heath, Adel M. Talaat, Ruth Sullivan, Sarah A. Marcus, Rebekah K. Franklin, Butch K. KuKanich, Lisa Krugner-Higby
Publikováno v:
Drug Metabolism and Disposition
Doxycycline (doxy) is used in treating intracellular and extracellular infections. Liposomal (LE) antibiotics allow low-frequency dosing and extended efficacy compared with standard (STD) formulations. We developed a novel sulfuric acid–loading met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8276433f55430a155c003cee2acccc9f
Publikováno v:
Veterinary Anaesthesia and Analgesia. 40:537-545
Objective To evaluate the pharmacokinetics, in dogs, of liposome–encapsulated oxymorphone and hydromorphone made by the ammonium sulfate gradient loading technique (ASG). Animals Four healthy purpose–bred Beagles aged 9.5 ± 3.2 months and weighi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd8e17a6efd7e7dba4014f05da3ba11
https://doi.org/10.1111/vaa.12042
https://doi.org/10.1111/vaa.12042
Autor:
Joanne R Paul-Murphy, Timothy D. Heath, Nicholas S. Keuler, David Sanchez-Migallon Guzman, Lisa Krugner-Higby, Jana M. Braun, Paulo V. Steagall, Carolyn S. Brown
Publikováno v:
American Journal of Veterinary Research. 74:196-200
Objective—To evaluate the thermal antinociceptive effects and duration of action of nalbuphine decanoate after IM administration to Hispaniolan Amazon parrots (Amazona ventralis). Animals—10 healthy adult Hispaniolan Amazon parrots of unknown sex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5989544fb6ccae248ed0c132fb03d6
https://doi.org/10.2460/ajvr.74.2.196
https://doi.org/10.2460/ajvr.74.2.196
Autor:
Joanne R Paul-Murphy, Timothy D. Heath, Carolyn S. Brown, Steven A. Barker, Lisa Krugner-Higby, Butch KuKanich, David Sanchez-Migallon Guzman
Publikováno v:
American Journal of Veterinary Research. 74:191-195
Objective—To evaluate the pharmacokinetics of nalbuphine decanoate after IM administration to Hispaniolan Amazon parrots (Amazona ventralis). Animals—9 healthy adult Hispaniolan Amazon parrots of unknown sex. Procedures—Nalbuphine decanoate (37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414cdc3b3fb751e76586bbcdc512dd98
https://doi.org/10.2460/ajvr.74.2.191
https://doi.org/10.2460/ajvr.74.2.191
Autor:
Andrea Smetana, Timothy D. Heath, Carolyn S. Brown, Brynn Schmidt, Lisa Krugner-Higby, Laura Wunsch, Lesley J. Smith
Publikováno v:
Journal of the American Animal Hospital Association. 47:185-195
The purpose of this study was to determine the experimental side effects of liposome-encapsulated hydromorphone (LE-Hydro) in beagles and to evaluate LE-Hydro analgesia in dogs undergoing ovariohysterectomies (OVH). Beagles were injected subcutaneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389216122cac83f616f5c7b7c532e58b
https://doi.org/10.5326/jaaha-ms-5599
https://doi.org/10.5326/jaaha-ms-5599
Autor:
Timothy D. Heath, Eric J. Wagner, Jennifer R. Mather, Cecilia Scholcoff, Lisa Krugner-Higby, Carolyn S. Brown
Publikováno v:
Journal of Pharmaceutical Sciences. 99:1800-1809
We have used a murine model of Acetaminophen induced hepatoxicity to determine if S-adenosyl methionine 1,4 butanedisulfonate (SD4) in liposomes can prevent liver injury when administered immediately prior to acetaminophen, as judged by serum asparta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573ca56ea6c402f276c4c27558f2b33c
https://doi.org/10.1002/jps.21950
https://doi.org/10.1002/jps.21950
Autor:
Carolyn S. Brown, Julia M. Klauer, Joanne R Paul-Murphy, Nicholas S. Keuler, Timothy D. Heath, Lisa Krugner-Higby, Ben Stading, Kurt K. Sladky
Publikováno v:
American Journal of Veterinary Research. 70:1201-1210
Objective—To evaluate the microcrystalline sodium urate (MSU) method for inducing arthritis in parrots and to compare the analgesic efficacy of long-acting liposome-encapsulated butorphanol (LEBT), carprofen, or a combination of both. Animals—20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4aa5350d40888bfacd54c267c807bbf
https://doi.org/10.2460/ajvr.70.10.1201
https://doi.org/10.2460/ajvr.70.10.1201
Autor:
Brynn Schmidt, Timothy D. Heath, Carolyn S. Brown, Lesley J. Smith, Lisa Krugner-Higby, Butch KuKanich
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 330:135-141
The objectives of the study were to determine the pharmacokinetics of oxymorphone (oxy) and of ammonium sulfate-loaded, liposome-encapsulated oxymorphone (LE-ASG oxy) and to evaluate the behavioral effects of both opioid preparations by using ethogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce96907e2737a3437082f07f727a7d6c
https://doi.org/10.1124/jpet.108.150052
https://doi.org/10.1124/jpet.108.150052