Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Timothy D. Christen"'
Autor:
Matthew Trendowski, Joseph N. Zoino, Timothy D. Christen, Christopher Acquafondata, Thomas P. Fondy
Publikováno v:
Translational Oncology, Vol 8, Iss 4, Pp 308-317 (2015)
An effective and inexpensive protocol for producing cytochalasins A and B is being disclosed to propose a viable method by which to examine the in vivo antineoplastic activity of these congeners in preclinical tumor-bearing mammalian models. In addit
Externí odkaz:
https://doaj.org/article/b3475074d10a476696731331b7c81668
Autor:
Matthew Trendowski, Victoria Wong, Thomas P. Fondy, Lauren Gadeberg, Joseph N. Zoino, Michelle Sansky, Timothy D. Christen
Publikováno v:
Cancer Letters. 360(2):160-170
Sonodynamic therapy (SDT) is a form of ultrasound therapy that has been shown to preferentially damage malignant cells based on the relatively enlarged size and altered cytology of neoplastic cells in comparison to normal cells. This study sought to
Publikováno v:
BMC Cancer
Background Although the actin cytoskeleton is vital for carcinogenesis and subsequent pathology, no microfilament-directed agent has been approved for cancer chemotherapy. One of the most studied classes of microfilament-directed agents has been the
Autor:
Thomas P. Fondy, Matthew Trendowski, Christopher Acquafondata, Timothy D. Christen, Joseph N. Zoino
Publikováno v:
Journal of Visualized Experiments : JoVE
Low frequency ultrasound in the 20 to 60 kHz range is a novel physical modality by which to induce selective cell lysis and death in neoplastic cells. In addition, this method can be used in combination with specialized agents known as sonosensitizer
Publikováno v:
European journal of medicinal chemistry. 98
Tetra-O-acetate haloacetamido carbohydrate analogs (Tet-OAHCs) are novel alkylating agents that appear to have alkylating activity at the plasma membrane, specificity against neoplastic cells, and may potentiate host leukocyte influx. This study soug
Publikováno v:
Cancer Research. 76:3802-3802
Despite inherent differences between the cytoskeletal networks of malignant and normal cells, and the clinical antineoplastic activity of microtubule-directed agents, there has yet to be a microfilament-directed agent approved for clinical use. Cytoc
Autor:
Thomas P. Fondy, Joseph N. Zoino, Timothy D. Christen, Christopher Acquafondata, Matthew Trendowski
Publikováno v:
Translational Oncology, Vol 8, Iss 4, Pp 308-317 (2015)
Translational Oncology
Translational Oncology
An effective and inexpensive protocol for producing cytochalasins A and B is being disclosed to propose a viable method by which to examine the in vivo antineoplastic activity of these congeners in preclinical tumor-bearing mammalian models. In addit
Autor:
Matthew Trendowski, Tenzin Kusang, Thomas P. Fondy, Timothy D. Christen, Antoaneta A. Andonova, Berlini Narampanawe, Ashlee Thibaud
Publikováno v:
Investigational New Drugs
SummaryThe mechanistic target of rapamycin (mTOR) controls cell growth and enlargement and has been found to be aberrant in a wide variety of malignancies. Although mTOR is already an attractive antineoplastic target, overexpression or aberrant expre