Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Timothy D. Bigby"'
Autor:
Cynthia S. Indralingam, Alma K. Gutierrez‐Gonzalez, Scott C. Johns, Tzuhan Tsui, Daniel T. Cannon, Mark M. Fuster, Timothy D. Bigby, Patricia A. Jennings, Ellen C. Breen
Publikováno v:
Physiological Reports, Vol 10, Iss 3, Pp n/a-n/a (2022)
Abstract Pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality. PAH is characterized by pulmonary artery remodeling, elevated right ventricular pressure (RVP) and, ultimately, cardiac failure. Pulmonary endothel
Externí odkaz:
https://doaj.org/article/c4c7b8281da64dfbabf6ca2aa3b147cb
Autor:
Jasmine Lee, Kendra L. Hailey, Timothy D. Bigby, Steven A. Vitorino, Ellen C. Breen, Patricia A. Jennings
Publikováno v:
American journal of respiratory cell and molecular biology, vol 61, iss 5
Chronic obstructive pulmonary disease (COPD) is a worldwide threat. Cigarette smoke (CS) exposure causes cardiopulmonary disease and COPD and increases the risk for pulmonary tumors. In addition to poor lung function, patients with COPD are susceptib
Autor:
Kunio Saruta, Jenna M. Magat, Jinghong Li, Mitra Rebek, Joanna Thomas, Dariush Ajami, Julius Rebek, Justin P. Dumouchel, Timothy D. Bigby
Publikováno v:
The Journal of Immunology. 200:4036-4043
IL-33 and its receptor ST2 play important roles in airway inflammation and contribute to asthma onset and exacerbation. The IL-33/ST2 signaling pathway recruits adapter protein myeloid differentiation primary response 88 (MyD88) to transduce intracel
Publikováno v:
Experimental physiology. 102(3)
What is the central question of this study? Non-invasive, quantitative methods to assess right cardiac function in mice with pulmonary hypertension have not been demonstrated. What is the main finding and its importance? This study shows the potentia
Publikováno v:
The FASEB Journal. 29
Pulmonary arterial hypertension (PAH) is a condition characterized by elevated mean pulmonary artery pressure, pulmonary vascular remodeling and secondary right heart failure. Mouse models are inst...
Publikováno v:
Annals of Allergy, Asthma & Immunology. 97:190-195
Background Intranasal administration of aspirin-lysine has been used in Europe for the diagnosis of aspirin-exacerbated respiratory disease. It has a low adverse effect profile and is believed to be safer for asthmatic patients, particularly those wi
Publikováno v:
American Journal of Physiology-Cell Physiology. 288:C1125-C1133
We examined induced expression of the 5-lipoxygenase-activating protein (FLAP), which is critical for leukotriene synthesis in mononuclear phagocytes. Prolonged exposure to the bacterial component, lipopolysaccharide (LPS), increased FLAP gene transc
Autor:
Timothy D. Bigby, Lev Libet, Eyal Raz, Kenji Takabayashi, Anthony A. Horner, Chul Hee Lee, Chae-Seo Rhee, Stephen M. Baird, Dugald Chisholm
Publikováno v:
Immunology. 113:106-113
While effective for the prevention and treatment of allergic rhinitis (AR) symptoms, currently available medications do not reverse allergen specific hypersensitivities. Therefore, pharmacotherapeutics are not curative and their daily use is often re
Autor:
Sriram S. Narsipur, Timothy D. Bigby, Francis B. Gabbai, Robert C. Smith, Orjan W. Peterson, Sampath Parthasarathy, Roland C. Blantz, Curtis B. Wilson
Publikováno v:
Journal of the American Society of Nephrology. 14:1748-1755
Significant glomerular vasoconstriction and production of reactive oxygen species has been known to occur with exposure to anti-glomerular basement membrane antibody (AGBM-Ab) in the rat model. Previously published studies have demonstrated that such
Publikováno v:
Journal of Biological Chemistry. 278:13810-13818
We examined expression of the 5-lipoxygenase activating protein (FLAP), which is critical for inflammatory cell leukotriene synthesis. A 3.4-kb segment of the FLAP gene 5'-untranslated region accounted for a 22-fold increase in promoter activity when