Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Timothy D Le Cras"'
Autor:
Timothy D Le Cras, Elisa Boscolo
Publikováno v:
Vascular Biology, Vol 1, Iss 1, Pp H33-H40 (2019)
The phosphoinositide 3-kinase (PI3K) pathway is a major mediator of growth factor signaling, cell proliferation and metabolism. Somatic gain-of-function mutations in PIK3CA, the catalytic subunit of PI3K, have recently been discovered in a number of
Externí odkaz:
https://doaj.org/article/b60078ec21d04d9b8c6304ffc2d65d8e
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54426 (2013)
The mammalian target of rapamycin (mTOR) plays an important role in cell growth/differentiation, integrating environmental cues, and regulating immune responses. Our lab previously demonstrated that inhibition of mTOR with rapamycin prevented house d
Externí odkaz:
https://doaj.org/article/67719c46f48c4d68bf2e78e98fb4518e
Autor:
Gerald B Lee, Eric B Brandt, Chang Xiao, Aaron M Gibson, Timothy D Le Cras, Lou Ann S Brown, Anne M Fitzpatrick, Gurjit K Khurana Hershey
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60632 (2013)
Diesel exhaust particle (DEP) exposure enhances allergic inflammation and has been linked to the incidence of asthma. Oxidative stress on the thiol molecules cysteine (Cys) and glutathione (GSH) can promote inflammatory host responses. The effect of
Externí odkaz:
https://doaj.org/article/de105367b1c04fa7ae99ff3af3d59e37
Autor:
Elizabeth M Mushaben, Gurjit Khurana Hershey, Michael W Pauciulo, William C Nichols, Timothy D Le Cras
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32468 (2012)
Loss-of-function mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene have been identified in patients with heritable pulmonary arterial hypertension (PAH); however, disease penetrance is low, suggesting additional factors play a
Externí odkaz:
https://doaj.org/article/5dbbd149044f4910a502e42253d5c70a
Autor:
Elisa Boscolo, Patricia Pastura, Sandra Schrenk, Jillian Goines, Rachael Kang, Devin Pillis, Punam Malik, Timothy D. Le Cras
Publikováno v:
Angiogenesis. 25:331-342
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7064664e88f9f0520fd4cb852f6cc832
https://doi.org/10.1007/s10456-022-09836-7
https://doi.org/10.1007/s10456-022-09836-7
Autor:
C. Griffin McDaniel, Denise M. Adams, Kimberley E. Steele, Adrienne M. Hammill, A. Carl Merrow, Janet L. Crane, Christopher L. Smith, Harry P. W. Kozakewich, Timothy D. Le Cras
Publikováno v:
Pediatric Blood & Cancer. 70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c972028cdaa70e422539d392946800ad
https://doi.org/10.1002/pbc.30219
https://doi.org/10.1002/pbc.30219
Autor:
Timothy D. Le Cras, Brandon Michael Henry, Giuseppe Lippi, Justin L. Benoit, David S. Cooper, Isaac Cheruiyot, Maria Helena Santos de Oliveira, Stefanie W. Benoit
Publikováno v:
Angiogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8804b17da08c8274eb2a403602bf9c2
http://europepmc.org/articles/PMC7985913
http://europepmc.org/articles/PMC7985913
Autor:
Nora Lakes, Denise M. Adams, Patricia A. Pastura, Elisa Boscolo, Adrienne M. Hammill, Jillian Goines, Timothy D. Le Cras
Publikováno v:
Angiogenesis
Capillary lymphatic venous malformations (CLVM) are complex vascular anomalies characterized by aberrant and enlarged lymphatic and blood vessels. CLVM appear during fetal development and enlarge after birth, causing life-long complications such as c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cf948748f6e0a193f3276a3a658448
https://doi.org/10.1007/s10456-020-09722-0
https://doi.org/10.1007/s10456-020-09722-0
Autor:
Elisa, Boscolo, Patricia, Pastura, Sandra, Schrenk, Jillian, Goines, Rachael, Kang, Devin, Pillis, Punam, Malik, Timothy D, Le Cras
Publikováno v:
Angiogenesis
Somatic mutations in NRAS drive the pathogenesis of melanoma and other cancers but their role in vascular anomalies and specifically human endothelial cells is unclear. The goals of this study were to determine whether the somatic-activating NRAS(Q61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be78c0ad8a39011de89b237b5ecea5fc
https://pubmed.ncbi.nlm.nih.gov/35391614
https://pubmed.ncbi.nlm.nih.gov/35391614
Autor:
Elisa Boscolo, Xian Li, Adam Lane, Lars Brichta, Timothy D. Le Cras, Jillian Goines, Yuqi Cai, Patricia A. Pastura
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective— Venous malformations (VMs) arise from developmental defects of the vasculature and are characterized by massively enlarged and tortuous venous channels. VMs grow commensurately
Objective— Venous malformations (VMs) arise from developmental defects of the vasculature and are characterized by massively enlarged and tortuous venous channels. VMs grow commensurately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb9654fa8f0dded168de832cbe7c646
http://europepmc.org/articles/PMC6392210
http://europepmc.org/articles/PMC6392210