Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: Findings from a study of 37,843 people in UK Biobank

Autor: Rhona A. Beynon, Fiona R. Saunders, Raja Ebsim, Monika Frysz, Benjamin G. Faber, Jennifer S. Gregory, Claudia Lindner, Aliya Sarmanova, Richard M. Aspden, Nicholas C. Harvey, Timothy Cootes, Jonathan H. Tobias

Publikováno v: Osteoarthritis and Cartilage Open, Vol 6, Iss 2, Pp 100468- (2024)

Objective: We aimed to create an imaging biomarker for knee shape using knee dual-energy x-ray absorptiometry (DXA) scans and investigate its potential association with subsequent total knee replacement (TKR), independently of radiographic features o

Externí odkaz: https://doaj.org/article/c4c3ff415ab44f73aa0ce2a06285f078

Surrogate vascular input function measurements from the superior sagittal sinus are repeatable and provide tissue-validated kinetic parameters in brain DCE-MRI

Autor: Daniel Lewis, Xiaoping Zhu, David J. Coope, Sha Zhao, Andrew T. King, Timothy Cootes, Alan Jackson, Ka-loh Li

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Accurate vascular input function (VIF) derivation is essential in brain dynamic contrast-enhanced (DCE) MRI. The optimum site for VIF estimation is, however, debated. This study sought to compare VIFs extracted from the internal carotid arte

Externí odkaz: https://doaj.org/article/f5f0fd600e9044c2aae76b9af6408220

Deriving alpha angle from anterior-posterior dual-energy x-ray absorptiometry scans: an automated and validated approach [version 2; peer review: 2 approved]

Autor: George Davey Smith, Benjamin G. Faber, Monika Frysz, Fiona R. Saunders, Raja Ebsim, Jonathan H. Tobias, Claudia Lindner, Timothy Cootes

Publikováno v: Wellcome Open Research, Vol 6 (2022)

Introduction: Alpha angle (AA) is a widely used imaging measure of hip shape that is commonly used to define cam morphology, a bulging of the lateral aspect of the femoral head. Cam morphology has shown strong associations with hip osteoarthritis (OA

Externí odkaz: https://doaj.org/article/34ec24b7713345399b1392d981c0d0bc

A Genome‐Wide Association Study Meta‐Analysis of Alpha Angle Suggests Cam‐Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults

Autor: Benjamin G. Faber, Monika Frysz, April E. Hartley, Raja Ebsim, Cindy G. Boer, Fiona R. Saunders, Jennifer S. Gregory, Richard M. Aspden, Nicholas C. Harvey, Lorraine Southam, William Giles, Christine L. Le Maitre, J. Mark Wilkinson, Joyce B.J. van Meurs, Eleftheria Zeggini, Timothy Cootes, Claudia Lindner, John P. Kemp, George Davey Smith, Jonathan H. Tobias

Publikováno v: Faber, B G, Frysz, M, Hartley, A E, Ebsim, R, Boer, C G, Saunders, F R, Gregory, J S, Aspden, R M, Harvey, N C, Southam, L, Giles, W, Le Maitre, C L, Wilkinson, J M, van Meurs, J B J, Zeggini, E, Cootes, T, Lindner, C, Kemp, J P, Davey Smith, G & Tobias, J H 2023, ' A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults ', Arthritis & rheumatology (Hoboken, N.J.) . https://doi.org/10.1002/art.42451
Faber, B G, Frysz, M, Hartley, A E, Ebsim, R, Boer, C G, Saunders, F R, Gregory, J S, Aspden, R M, Harvey, N C, Southam, L, Giles, W, Le Maitre, C L, Wilkinson, J M, van Meurs, J B J, Zeggini, E, Cootes, T, Lindner, C, Kemp, J P, Davey Smith, G & Tobias, J H 2023, ' A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults ', Arthritis and Rheumatology, vol. 75, no. 6, pp. 900-909 . https://doi.org/10.1002/art.42451
Arthritis and Rheumatology, 75(6), 900-909. John Wiley & Sons Ltd.

Objective: To examine the genetic architecture of cam morphology using alpha angle (AA) as a proxy measure and conduct an AA genome-wide association study (GWAS) followed by Mendelian randomization (MR) to evaluate its causal relationship with hip os

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd8b0936adf27c13378ae0983ce92e5
https://doi.org/10.1002/art.42451

OA20 Radiographic hip osteoarthritis classified semi-automatically on dual-energy x-ray absorptiometry scans is strongly predictive of total hip replacement: findings from UK Biobank

Autor: Benjamin G Faber, Raja Ebsim, Fiona R Saunders, Monika Frysz, Claudia Lindner, Jennifer S Gregory, Richard M Aspden, Nicholas C Harvey, George Davey Smith, Timothy Cootes, Jonathan H Tobias

Publikováno v: Rheumatology. 61

Background/Aims Radiographic hip osteoarthritis (rHOA) is traditionally defined on hip x-rays, using subjective methods such as Kellgren-Lawrence scoring. Associations between subjective rHOA measures and symptoms are inconsistent. Applying digital t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e26630c76670b35ad5a81db8e059a74
https://doi.org/10.1093/rheumatology/keac132.020