Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Timothy Cardozo"'
Autor:
Mohammad Arif Rahman, Manuel Becerra-Flores, Yury Patskovsky, Isabela Silva de Castro, Massimiliano Bissa, Shraddha Basu, Xiaoying Shen, LaTonya D. Williams, Sarkis Sarkis, Kombo F. N’guessan, Celia LaBranche, Georgia D. Tomaras, Pyone Pyone Aye, Ronald Veazey, Dominic Paquin-Proulx, Mangala Rao, Genoveffa Franchini, Timothy Cardozo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionAn efficacious HIV vaccine will need to elicit a complex package of innate, humoral, and cellular immune responses. This complex package of responses to vaccine candidates has been studied and yielded important results, yet it has been a
Externí odkaz:
https://doaj.org/article/f271626acd674386b239c0823d800dfb
Autor:
Sang Bae Lee, Luciano Garofano, Aram Ko, Fulvio D’Angelo, Brulinda Frangaj, Danika Sommer, Qiwen Gan, KyeongJin Kim, Timothy Cardozo, Antonio Iavarone, Anna Lasorella
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Tissue-specific transcriptional activity is silenced in mitotic cells. Here the authors reveal a general phosphorylation-dependent mechanism of recognition for the anaphase-promoting complex (APC) substrates, and show that the APC targets ID2 during
Externí odkaz:
https://doaj.org/article/6f441f5daf114e89a17e33b1ead8f3cd
Autor:
Deepika Vasudevan, Sarah D. Neuman, Amy Yang, Lea Lough, Brian Brown, Arash Bashirullah, Timothy Cardozo, Hyung Don Ryoo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Translation of ATF4 mRNA is stimulated during the integrated stress response. Here the authors show that two noncanonical translation initiation factors eIF2D and DENR are required for translational induction of ATF4 mRNA in Drosophila and human cell
Externí odkaz:
https://doaj.org/article/cb19d805a6b24e2eacdacbc663f41ff9
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Autoimmune diseases are often associated with autoantibodies that abnormally target self-antigens (autoantigens). An intuitive therapeutic strategy for diseases caused by aAbs is to design decoys, or soluble molecules that target the antigen combinin
Externí odkaz:
https://doaj.org/article/bf1af461684546c2af61dbcff94b4f91
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Tyrosinase (TYR) is a copper-containing monooxygenase central to the function of melanocytes. Alterations in its expression or activity contribute to variations in skin, hair and eye color, and underlie a variety of pathogenic pigmentary phenotypes,
Externí odkaz:
https://doaj.org/article/1ccbb8e8c9fa48e6becdf097d1853670
Autor:
David N. Hernandez, Kayan Tam, Bo Shopsin, Emily E. Radke, Karen Law, Timothy Cardozo, Victor J. Torres, Gregg J. Silverman
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Staphylococcus aureus infection is a major public health threat in part due to the spread of antibiotic resistance and repeated failures to develop a protective vaccine. Infection is associated with production of virulence factors that inclu
Externí odkaz:
https://doaj.org/article/5fd5c02cfeea46f7987a4235a59bedfc
Autor:
Laurensia Yuniati, Angela Lauriola, Manouk Gerritsen, Susana Abreu, Eric Ni, Chiara Tesoriero, Jacob O. Onireti, Teck Yew Low, Albert J.R. Heck, Andrea Vettori, Timothy Cardozo, Daniele Guardavaccaro
Publikováno v:
Cell Reports, Vol 31, Iss 7, Pp - (2020)
Summary: Cullin-RING ligases (CRLs) control key cellular processes by promoting ubiquitylation of a multitude of soluble cytosolic and nuclear proteins. Subsets of CRL complexes are recruited and activated locally at cellular membranes; however, few
Externí odkaz:
https://doaj.org/article/787396060bef4facbcca34a0292af729
Autor:
Lea Lough, Dan Sherman, Manuel Becerra-Flores, Deepika Vasudevan, Olga Lavinda, Eric Ni, Hong Wang, Hyung Don Ryoo, Raoul Tibes, Timothy Cardozo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1092- (2020)
Externí odkaz:
https://doaj.org/article/cbe1d0a197a840e29dee21cd26fc075e
Autor:
Lea Lough, Dan Sherman, Manuel Becerra-Flores, Deepika Vasudevan, Olga Lavinda, Eric Ni, Hong Wang, Hyung Don Ryoo, Raoul Tibes, Timothy Cardozo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 350-360 (2018)
Cellular stress signals activate adaptive signaling pathways of the mammalian integrated stress response (ISR), of which the unfolded protein response (UPR) is a subset. These pathways converge at the phosporylation of eIF2α. Drug-like, potent and s
Externí odkaz:
https://doaj.org/article/b2607cfd86264689b36c66533b602104
Autor:
Alexandra M. Pinzaru, Robert A. Hom, Angela Beal, Aaron F. Phillips, Eric Ni, Timothy Cardozo, Nidhi Nair, Jaehyuk Choi, Deborah S. Wuttke, Agnel Sfeir, Eros Lazzerini Denchi
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2170-2184 (2016)
Genome sequencing studies have revealed a number of cancer-associated mutations in the telomere-binding factor POT1. Here, we show that when combined with p53 deficiency, depletion of murine POT1a in common lymphoid progenitor cells fosters genetic i
Externí odkaz:
https://doaj.org/article/41a03a414ad34762bf0a0a0270c0b8f8