Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Timothy C. Meredith"'
Autor:
Michael Maybin, Aditi M. Ranade, Ursula Schombel, Nicolas Gisch, Uwe Mamat, Timothy C. Meredith
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Polymyxins [colistin and polymyxin B (PMB)] comprise an important class of natural product lipopeptide antibiotics used to treat multidrug-resistant Gram-negative bacterial infections. These positively charged lipopeptides interact with lipo
Externí odkaz:
https://doaj.org/article/93209f08620b44d7839200c2088766f4
Autor:
John H. Gardiner, Gloria Komazin, Miki Matsuo, Kaitlin Cole, Friedrich Götz, Timothy C. Meredith
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Bacterial lipoproteins (Lpps) are a class of membrane-associated proteins universally distributed among all bacteria. A characteristic N-terminal cysteine residue that is variably acylated anchors C-terminal globular domains to the extracell
Externí odkaz:
https://doaj.org/article/0dc2e21b11354398ab1fff8f78158146
Autor:
Bruno P. Lima, Kelvin Kho, Brittany L. Nairn, Julia R. Davies, Gunnel Svensäter, Ruoqiong Chen, Amanda Steffes, Gerrit W. Vreeman, Timothy C. Meredith, Mark C. Herzberg
Publikováno v:
mSphere, Vol 4, Iss 6 (2019)
ABSTRACT Lipoteichoic acid (LTA) is an abundant polymer of the Gram-positive bacterial cell envelope and is essential for many species. Whereas the exact function of LTA has not been elucidated, loss of LTA in some species affects hydrophobicity, bio
Externí odkaz:
https://doaj.org/article/5dc7f64bae3c4a60aede78db657e9911
Autor:
Kathryn A Coe, Wonsik Lee, Madeleine C Stone, Gloria Komazin-Meredith, Timothy C Meredith, Yonatan H Grad, Suzanne Walker
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1007862 (2019)
Antibiotic-resistant Staphylococcus aureus remains a leading cause of antibiotic resistance-associated mortality in the United States. Given the reality of multi-drug resistant infections, it is imperative that we establish and maintain a pipeline of
Externí odkaz:
https://doaj.org/article/a3fcbfb5357d44ef956c36af3b3fe34d
Autor:
Jacob D. Muscato, Heidi G. Morris, Aaron Mychack, Mithila Rajagopal, Vadim Baidin, Anthony R. Hesser, Wonsik Lee, Kemal İnecik, Laura J. Wilson, Christina M. Kraml, Timothy C. Meredith, Suzanne Walker
Publikováno v:
Journal of the American Chemical Society. 144:3696-3705
Synthetic lethality occurs when inactivation of two genes is lethal but inactivation of either single gene is not. This phenomenon provides an opportunity for efficient compound discovery. Using differential growth screens, one can identify biologica
Autor:
Gloria Komazin, Amena A. Rizk, Krista M. Armbruster, Victoria A. Bonnell, Manuel Llinás, Timothy C. Meredith
Publikováno v:
Journal of Bacteriology. 205
Bacterial lipoproteins are membrane-associated proteins with a characteristic acylated N-terminal cysteine residue anchoring C-terminal globular domains to the membrane surface. While all lipoproteins are modified with acyl chains, the number, length
Autor:
Amena A. Rizk, Gloria Komazin, Michael Maybin, Nushrat Hoque, Emily Weinert, Timothy C. Meredith
Publikováno v:
Journal of bacteriology.
Two-component extracellular copper sensing from the periplasm of Gram-negative bacteria has been well studied, but copper detection at the cell surface of the Gram-positive L. monocytogenes is less understood. Collectively, our results show that EET
Publikováno v:
J Biol Chem
All bacterial lipoproteins share a variably acylated N-terminal cysteine residue. Gram-negative bacterial lipoproteins are triacylated with a thioether-linked diacylglycerol moiety and an N-acyl chain. The latter is transferred from a membrane phosph
Publikováno v:
Mol Microbiol
Surface proteins of Staphylococcus aureus play vital roles in bacterial physiology and pathogenesis. Recent work suggests that surface proteins are spatially regulated by a YSIRK/GXXS signal peptide that promotes cross-wall targeting at the mid-cell,
Autor:
Kaitlin Cole, Timothy C. Meredith, Friedrich Götz, John H. Gardiner, Miki Matsuo, Gloria Komazin
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
Bacterial lipoproteins (Lpps) are a class of membrane-associated proteins universally distributed among all bacteria. A characteristic N-terminal cysteine residue that is variably acylated anchors C-terminal globular domains to the extracellular surf