Výsledky vyhledávání - "Timothy C. Horan"

Akademický článek

Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model.

Autor: Richard G Moore, Thilo S Lange, Katina Robinson, Kyu K Kim, Alper Uzun, Timothy C Horan, Nada Kawar, Naohiro Yano, Sharon R Chu, Quanfu Mao, Laurent Brard, Monique E DePaepe, James F Padbury, Leggy A Arnold, Alexander Brodsky, Tun-Li Shen, Rakesh K Singh

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34443 (2012)

BACKGROUND:Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hypercalcemia in human trials to treat cancer. We identified the first non-hypercalcemic anti-cancer vitamin D analog MT19c by altering the A-ring of er

Externí odkaz: https://doaj.org/article/1ab19dbd7f644ccbadcc68da0d5af459

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PT19c, Another Nonhypercalcemic Vitamin D2 Derivative, Demonstrates Antitumor Efficacy in Epithelial Ovarian and Endometrial Cancer Models

Autor: Nicholi Vorsa, Preetpal S. Sidhu, Thilo S. Lange, Laurent Brard, N. Kawar, Russell Hopson, Timothy C. Horan, Shannon MacLaughlan, James F. Padbury, Richard G. Moore, Alper Uzun, Rakesh K. Singh, Ajay P. Singh, Kyle A. Glass, Sunil K. Shaw, Leggy A. Arnold, Kyu K. Kim

Publikováno v: Genes & Cancer. 4:524-534

Hypercalcemia remains a major impediment to the clinical use of vitamin D in cancer treatment. Approaches to remove hypercalcemia and development of nonhypercalcemic agents can lead to the development of vitamin D-based therapies for treatment of var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe48b8abc5ea0e9cf7203e9ca9af784b
https://doi.org/10.1177/1947601913507575

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Cytotoxic Properties of Adamantyl Isothiocyanate and Potential In vivo Metabolite Adamantyl-N-Acetylcystein in Gynecological Cancer Cells

Autor: Nicholi Vorsa, Richard G. Moore, Thilo S. Lange, Kyu K. Kim, Ajay P. Singh, Timothy C. Horan, Laurent Brard, Rakesh K. Singh

Publikováno v: Chemical Biology & Drug Design. 79:92-103

This study determined the in vitro potential of novel compounds adamantyl-N-acetylcystein and adamantyl isothiocyanate to treat gynecological cancers. Adamantyl-N-acetylcystein is postulated to be an in vivo metabolite of adamantyl isothiocyanate as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a0faadc8759d856fd49e1d41ea3035c
https://doi.org/10.1111/j.1747-0285.2011.01251.x

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HE4 (WFDC2) gene overexpression promotes ovarian tumor growth

Autor: Naohiro Yano, Shannon MacLaughlan, Emily K. Hill, Rakesh K. Singh, James F. Padbury, M. Craig Miller, Kyu Kwang Kim, Thilo S. Lange, Timothy C. Horan, YiTang Don Tseng, Richard G. Moore, Geralyn Lambert-Messerlian

Publikováno v: Scientific Reports

Selective overexpression of Human epididymal secretory protein E4 (HE4) points to a role in ovarian cancer tumorigenesis but little is known about the role the HE4 gene or the gene product plays. Here we show that elevated HE4 serum levels correlate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68889c33e67dc15832a9512dd52a5e30
http://europepmc.org/articles/PMC3880958

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7 Methyl indole ethyl isothiocyanate causes ROS mediated apoptosis and cell cycle arrest in endometrial cancer cells

Autor: Joong Sub Choi, Laurent Brard, Kyu Kwang Kim, Timothy C. Horan, Katrin Kristjansdottir, Rakesh K. Singh, Richard G. Moore

Publikováno v: Gynecologic oncology. 126(2)

Objective Chemotherapy options for advanced endometrial cancer are limited and newer therapeutic agents are urgently needed. This study describes the therapeutic potential of 7 Methyl-indole ethyl isothiocyanate (7Me-IEITC) in endometrial cancer cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972fbb8dd3f947da143d068e6507b85d
https://pubmed.ncbi.nlm.nih.gov/22561404

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Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model

Autor: Quanfu Mao, Katina Robinson, Leggy A. Arnold, Tun-Li Shen, Alexander S. Brodsky, James F. Padbury, Naohiro Yano, Kyu K. Kim, Timothy C. Horan, Alper Uzun, Laurent Brard, N. Kawar, Sharon Chu, Monique E. DePaepe, Thilo S. Lange, Rakesh K. Singh, Richard G. Moore

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34443 (2012)
PLoS ONE

Background Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hypercalcemia in human trials to treat cancer. We identified the first non-hypercalcemic anti-cancer vitamin D analog MT19c by altering the A-ring of er

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931d2966003d2889e08df4e62ed51560
http://europepmc.org/articles/PMC3317945?pdf=render

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Cytotoxic properties of Adamantyl isothiocyanate and potential in vivo metabolite adamantyl-N-acetylcystein in gynecological cancer cells

Autor: Thilo S, Lange, Timothy C, Horan, Kyu K, Kim, Ajay P, Singh, Nicholi, Vorsa, Laurent, Brard, Richard G, Moore, Rakesh K, Singh

Publikováno v: Chemical biologydrug design. 79(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f6147a4e615f77803135a9399f166fe
https://pubmed.ncbi.nlm.nih.gov/21974809

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Purified cranberry proanthocyanidines (PAC-1A) cause pro-apoptotic signaling, ROS generation, cyclophosphamide retention and cytotoxicity in high-risk neuroblastoma cells

Autor: Nicholi Vorsa, Kyu K. Kim, Richard G. Moore, Rakesh K. Singh, Ajay P. Singh, Laurent Brard, Thilo S. Lange, Timothy C. Horan

Publikováno v: International Journal of Oncology.

Optimized purification of oligomeric proanthocyanidines (PAC) from cranberry generated PAC-1A which selectively affected the viability of various neuroblastoma (NB) cell lines representing a spectrum of high-risk NB features. PAC-1A caused a loss of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4ff00a63374f74cea0864286676e7f
https://doi.org/10.3892/ijo.2011.1225

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Description of the cytotoxic effect of a novel drug Abietyl-Isothiocyanate on endometrial cancer cell lines

Autor: Thilo S. Lange, Richard G. Moore, Timothy C. Horan, Kyu Kwang Kim, Christopher T. Seto, Michael A. Zompa

Publikováno v: Investigational new drugs. 30(4)

The objective of the present study was to determine the in-vitro effect of Abietyl-Isothiocyanate (ABITC), a representative of a new class of anti-cancer drugs, on endometrial cancer (EC) cell lines. ABITC at concentrations ≥1 μM displayed dose-de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbc7ca43c6621b7a92b924820d4d4c3
https://pubmed.ncbi.nlm.nih.gov/21809024

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