Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Timothy C. Elston"'
Autor:
Siarhei Hladyshau, Kaiyun Guan, Nivedita Nivedita, Beverly Errede, Denis Tsygankov, Timothy C. Elston
Publikováno v:
Cells, Vol 13, Iss 16, p 1358 (2024)
Cell polarity refers to the asymmetric distribution of proteins and other molecules along a specified axis within a cell. Polarity establishment is the first step in many cellular processes. For example, directed growth or migration requires the form
Externí odkaz:
https://doaj.org/article/82fdabb893754399bcbd11ad374eae0f
Autor:
J. Cody Herron, Shiqiong Hu, Takashi Watanabe, Ana T. Nogueira, Bei Liu, Megan E. Kern, Jesse Aaron, Aaron Taylor, Michael Pablo, Teng-Leong Chew, Timothy C. Elston, Klaus M. Hahn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Podosomes are actin structures important in multiple cell functions. Here, the authors use iPALM microscopy to reveal an “hourglass” shape of the podosome actin core, a protruding “knob” at the bottom of the core, and two actin networks exten
Externí odkaz:
https://doaj.org/article/1167ad13520d4e38b9c084543afa1e3a
Autor:
Luhong Jin, Bei Liu, Fenqiang Zhao, Stephen Hahn, Bowei Dong, Ruiyan Song, Timothy C. Elston, Yingke Xu, Klaus M. Hahn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Super-resolution microscopy typically requires high laser powers which can induce photobleaching and degrade image quality. Here the authors augment structured illumination microscopy (SIM) with deep learning to reduce the number of raw images requir
Externí odkaz:
https://doaj.org/article/cb59b1d9328d413d81e5520a618431fc
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Cell migration refers to the ability of cells to translocate across a substrate or through a matrix. To achieve net movement requires spatiotemporal regulation of the actin cytoskeleton. Computational approaches are necessary to identify and quantify
Externí odkaz:
https://doaj.org/article/0bf369615a73480585d86af1d9a9b2be
Autor:
Virginia Tajadura-Ortega, Ritu Garg, Richard Allen, Claudia Owczarek, Michael D. Bright, Samuel Kean, Aisyah Mohd-Noor, Anita Grigoriadis, Timothy C. Elston, Klaus M. Hahn, Anne J. Ridley
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-20 (2018)
Abstract Background Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects migration has not be
Externí odkaz:
https://doaj.org/article/ff58e5f3ece74db8839b003b8eba8180
Autor:
Cherise R. Glodowski, Kevin R. Mott, Denis Okumu, Michael P. East, Timothy C. Elston, Gary L. Johnson, Charles M. Perou
Publikováno v:
Cancer Research. 83:PD4-09
Introduction: Triple Negative Breast Cancer (TNBC) is an aggressive disease with a poor prognosis that accounts for 10-20% of breast cancer cases worldwide. Intra-tumoral heterogeneity and tumor cell plasticity are thought to contribute to drug resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aed8cc4bc2c0b65710ad24ba0fd9eb9
https://doi.org/10.1158/1538-7445.sabcs22-pd4-09
https://doi.org/10.1158/1538-7445.sabcs22-pd4-09
Many cells adjust the direction of polarized growth or migration in response to external directional cues. The yeastSaccharomyces cerevisiaeorient their cell fronts (also called polarity sites) up pheromone gradients in the course of mating. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d3e5040568fa771981eb640ba67f101
https://doi.org/10.1101/2023.05.01.538889
https://doi.org/10.1101/2023.05.01.538889
Publikováno v:
Plant Physiol
G-proteins are molecular on–off switches that are involved in transmitting a variety of extracellular signals to their intracellular targets. In animal and yeast systems, the switch property is encoded through nucleotides: a GDP-bound state is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985bbb59a48039107b713862ca5b35a7
https://doi.org/10.1093/plphys/kiab534
https://doi.org/10.1093/plphys/kiab534
Publikováno v:
2022 European Control Conference (ECC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f01e4e7750bdff567c497fb736da8c1
https://doi.org/10.23919/ecc55457.2022.9838423
https://doi.org/10.23919/ecc55457.2022.9838423
Autor:
Daniel J. Lew, Michael Pablo, Nicholas T. Henderson, Debraj Ghose, Manuella R. Clark-Cotton, Timothy C. Elston
Publikováno v:
Molecular Biology of the Cell. 32:1048-1063
Yeast decode pheromone gradients to locate mating partners, providing a model for chemotropism. How yeast polarize toward a single partner in crowded environments is unclear. Initially, cells often polarize in unproductive directions, but then they r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc86d3d06f00c81326b26e4e9ea51d3c
https://doi.org/10.1091/mbc.e21-02-0068
https://doi.org/10.1091/mbc.e21-02-0068