Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Timothy C. Baranowski"'
Autor:
Lucjan Strekowski, Jarosław Sączewski, Elizabeth A. Raux, Nilmi T. Fernando, Jeff Klenc, Shirish Paranjpe, Aldona Raszkiewicz, Ava L. Blake, Adam J. Ehalt, Samuel Barnes, Timothy C. Baranowski, Shannon M. Sullivan, Grzegorz Satała, Andrzej J. Bojarski
Publikováno v:
Molecules, Vol 21, Iss 4, p 433 (2016)
A series of piperazin-1-yl substituted unfused heterobiaryls was synthesized as ligands of the 5-HT7 receptors. The goal of this project was to elucidate the structural features that affect the 5-HT7 binding affinity of this class of compounds repres
Externí odkaz:
https://doaj.org/article/9c87c1194100413685666fe2342c8fb9
Autor:
Eric M. Sandberg, Raymond Dingledine, Thanh N. Doan, Amy L. Rubinstein, Timothy C. Baranowski, Temitope Aiyejorun, Audrey White, Delali Blavo, Jamil Haider, Blossom Sneed, T. Cameron Tran
Supplementary Tables 1-2 from Automated, Quantitative Screening Assay for Antiangiogenic Compounds Using Transgenic Zebrafish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392aa07bb020147d584a4c8e6d8e9e6d
https://doi.org/10.1158/0008-5472.22370612
https://doi.org/10.1158/0008-5472.22370612
Autor:
Eric M. Sandberg, Raymond Dingledine, Thanh N. Doan, Amy L. Rubinstein, Timothy C. Baranowski, Temitope Aiyejorun, Audrey White, Delali Blavo, Jamil Haider, Blossom Sneed, T. Cameron Tran
Pathologic angiogenesis has emerged as an important therapeutic target in several major diseases. Zebrafish offer the potential for high-throughput drug discovery in a whole vertebrate system. We developed the first quantitative, automated assay for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c648c8b485a09004e9a0c96afeb422f1
https://doi.org/10.1158/0008-5472.c.6496457.v1
https://doi.org/10.1158/0008-5472.c.6496457.v1
Autor:
Samuel Barnes, Jarosław Sączewski, Andrzej J. Bojarski, Timothy C. Baranowski, Ava L. Blake, Shirish Paranjpe, Nilmi T Fernando, Adam J Ehalt, Grzegorz Satała, Jeffrey Klenc, Shannon Sullivan, Elizabeth Raux, Lucjan Strekowski, Aldona Raszkiewicz
Publikováno v:
Molecules; Volume 21; Issue 4; Pages: 433
Molecules, Vol 21, Iss 4, p 433 (2016)
Molecules, Vol 21, Iss 4, p 433 (2016)
A series of piperazin-1-yl substituted unfused heterobiaryls was synthesized as ligands of the 5-HT7 receptors. The goal of this project was to elucidate the structural features that affect the 5-HT7 binding affinity of this class of compounds repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef0c81b72b0995a81fcc36168d45cb9
Autor:
Jennifer L. Anderson, Elayne Provost, Steven A. Farber, Amy L. Rubinstein, Kotaro Hama, Steven D. Leach, Timothy C. Baranowski
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G445-G453
Optical clarity of larvae makes the zebrafish ideal for real-time analyses of vertebrate organ function through the use of fluorescent reporters of enzymatic activities. A key function of digestive organs is to couple the generation of enzymes with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f627558d4eb1d1844da0778d0c54c90
https://doi.org/10.1152/ajpgi.90513.2008
https://doi.org/10.1152/ajpgi.90513.2008
Autor:
Jamil Haider, Raymond Dingledine, Eric M. Sandberg, T. Cameron Tran, Amy L. Rubinstein, Audrey White, Delali Blavo, Thanh Doan, Timothy C. Baranowski, Blossom Sneed, Temitope Aiyejorun
Publikováno v:
Cancer Research. 67:11386-11392
Pathologic angiogenesis has emerged as an important therapeutic target in several major diseases. Zebrafish offer the potential for high-throughput drug discovery in a whole vertebrate system. We developed the first quantitative, automated assay for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3128bc237bd05eb95c41a25b49d148e5
https://doi.org/10.1158/0008-5472.can-07-3126
https://doi.org/10.1158/0008-5472.can-07-3126
Autor:
Marcin Król, Lucjan Strekowski, Ewa Broclawik, Tomasz Borowski, Maria J. Mokrosz, Timothy C. Baranowski
Publikováno v:
Journal of Medicinal Chemistry. 43:1901-1909
Antagonists of the 5-HT(2A) receptor are being used to treat many psychiatric disorders. The present work focuses on a group of 27 antagonists possessing varying affinities toward the receptor. These are 26 title compounds and clozapine as a referenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa6c08d052236396faee0cac6accf1d
https://doi.org/10.1021/jm9911332
https://doi.org/10.1021/jm9911332
Autor:
Ibrahim M. Abdou, Aleksandra Kłodzińska, Lucjan Strekowski, Maria J. Mokrosz, Timothy C. Baranowski, Beata Duszyńska, A. Deren‐Wesolek, Ewa Chojnacka-Wójcik, Naomi P. Redmore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1635-1638
The title pyrimidines 7–12 are potent 5-HT2A receptor ligands with fairly strong behavioral antagonistic activity. A comparison of the structural and binding properties within the entire group of these and other pyrimidines demonstrates two differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a19cf18716ede987b86645934754a771
https://doi.org/10.1016/s0960-894x(97)00291-6
https://doi.org/10.1016/s0960-894x(97)00291-6
Autor:
Lucjan Strekowski, Timothy C. Baranowski, W. D. Wilson, Alexander S. Kiselyov, Shou-Yuan Lin, Alesia N. Parker, Yuri Gulevich, Farial A. Tanious
Publikováno v:
ChemInform. 28
4-[N-(Aminoalkyl)amino]-2-arylquinolines with conformational freedom around positions 2 and 4 of the quinoline stabilize strongly poly(dT·dA·dT) (triplex DNA) and bind weakly to poly(dA·dT) (duplex DNA). Basicity of N1 of the quinoline parallels t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d92a615432fd3cbe04e4a26f6f559af
https://doi.org/10.1002/chin.199704162
https://doi.org/10.1002/chin.199704162
Autor:
Amy L. Rubinstein, Thanh Doan, Timothy C. Baranowski, Enid T. McKinley, Delali Blavo, Candace Cato
Publikováno v:
Brain research. Molecular brain research. 141(2)
Parkinson's disease is characterized by a severe loss of dopaminergic neurons resulting in a range of motor deficits. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is known to cause a similar loss of dopaminergic neurons in the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55324859e3e401f0839647172e0f53c8
https://pubmed.ncbi.nlm.nih.gov/16209898
https://pubmed.ncbi.nlm.nih.gov/16209898