Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Timothy C Hardman"'
Autor:
Timothy C Hardman, Rob Aitchison, Richard Scaife, Jean Edwards, Gill Slater, on behalf of the Committee of the Pharmaceutical Contract Management Group
Publikováno v:
Drugs in Context, Iss 12, Pp 1-11 (2023)
A workshop held at the 18th Annual Conference of the Pharmaceutical Contract Management Group in Krakow on 9 September 2022 asked over 200 delegates what the clinical trial landscape would look like in 2050. Issues considered included who will be run
Externí odkaz:
https://doaj.org/article/37e553d98af14ff69754bad71979b7c7
Autor:
Sergey V Efimov, Natallia V Matsiyeuskaya, Olga V Boytsova, Luydmila Yu Akhieva, Elena V Kuntsevich, Anastasia A Troshina, Elena I Kvasova, Anton A Tikhonov, Nadezhda F Khomyakova, Francisco Harrison, Jean-François Rossi, Timothy C Hardman
Publikováno v:
Drugs in Context, Vol 11, Pp 1-15 (2022)
Background: Evidence-based therapies used to treat coronavirus disease (COVID-19) remain limited. Azoximer bromide (AZB; Polyoxidonium®) is an immunomodulating molecule frequently used in the Russian Federation. It offers demonstrable therapeutic be
Externí odkaz:
https://doaj.org/article/b12998c3391243a29138d4def3168c6d
Autor:
Matthew C. Eastwood, John Busby, David J. Jackson, Ian D. Pavord, Catherine E. Hanratty, Ratko Djukanovic, Ashley Woodcock, Samantha Walker, Timothy C. Hardman, Joseph R. Arron, David F. Choy, Peter Bradding, Chris E. Brightling, Rekha Chaudhuri, Douglas Cowan, Adel H. Mansur, Stephen J. Fowler, Peter Howarth, James Lordan, Andrew Menzies-Gow, Timothy Harrison, Douglas S. Robinson, Cecile T.J. Holweg, John G. Matthews, Liam G. Heaney
Publikováno v:
Eastwood, M C, Busby, J, Jackson, D J, Pavord, I D, Hanratty, C E, Djukanovic, R, Woodcock, A, Walker, S, Hardman, T C, Arron, J R, Choy, D F, Bradding, P, Brightling, C E, Chaudhuri, R, Cowan, D, Mansur, A H, Fowler, S J, Howarth, P, Lordan, J, Menzies-Gow, A, Harrison, T, Robinson, D S, Holweg, C T J, Matthews, J G, Heaney, L G & RASPUK Investigators 2023, ' A randomized trial of a composite T2-biomarker strategy adjusting corticosteroid treatment in severe asthma: a post-hoc analysis by sex ', The Journal of Allergy and Clinical Immunology: In Practice, vol. 11, no. 4, pp. 1233-1242.e5 . https://doi.org/10.1016/j.jaip.2022.12.019
RASPUK Investigators 2023, ' A randomised trial of a T2-composite-biomarker strategy adjusting corticosteroidtreatment in severe asthma, a post-hoc analysis by sex ', The journal of allergy and clinical immunology. In practice . https://doi.org/10.1016/j.jaip.2022.12.019
RASPUK Investigators 2023, ' A randomised trial of a T2-composite-biomarker strategy adjusting corticosteroidtreatment in severe asthma, a post-hoc analysis by sex ', The journal of allergy and clinical immunology. In practice . https://doi.org/10.1016/j.jaip.2022.12.019
BackgroundApproximately 5% to 10% of patients with asthma have severe disease, with a consistent preponderance in females. Current asthma guidelines recommend stepwise treatment to achieve symptom control with no differential treatment considerations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2581de96dba8e402e322395e7e2048b7
https://pure.qub.ac.uk/en/publications/0e19d403-6512-483c-99ba-4c785bc87c1f
https://pure.qub.ac.uk/en/publications/0e19d403-6512-483c-99ba-4c785bc87c1f
Autor:
Susan Reijntjes, Muna Albayaty, James Bush, Joseph Cheriyan, Anthea Cromie, Annelize Koch, Michael Hammond, Stuart Mair, Peter Scholes, Ulrike Lorch, Steffan Stringer, Jorg Taubel, Timothy C. Hardman
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The Association for Human Pharmacology in the Pharmaceutical Industry (AHPPI) annual meeting focused on the changing face of early phase drug development and opened with a keynote speech concerning the revolution in pharmaceutical medicine over the l
Externí odkaz:
https://doaj.org/article/142ed6f8be4d431691147e0fb3990447
Autor:
Luc Van Bortel, Hildegard Sourgens, Kerstin Breithaupt-Grögler, Henri Caplain, Yves Donazzolo, Ingrid Klingmann, Michael Hammond, Timothy C. Hardman, Steffan Stringer, Jan de Hoon
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2018)
The first formal conference of the EUropean Federation for Exploratory MEdicines Development (EUFEMED) held in London was the result of a collaborative effort of its founding associations: the Association for Applied Human Pharmacology (AGAH; Germany
Externí odkaz:
https://doaj.org/article/e8d56503f6a649c0a713009e2c78b9b5
Autor:
Hildegard Sourgens, Katharina Erb-Zohar, Gerd Mikus, Frank Donath, Kerstin Breithaupt-Groegler, Stephanie Plassmann, Jens Rengelshausen, Georg Wensing, Timothy C. Hardman
Publikováno v:
Therapeutic Innovation & Regulatory Science
Purpose A discussion forum was hosted by the Association for Applied Human Pharmacology (AGAH e.V.) to critically debate how to interpret and optimise the Investigator’s Brochure (IB) for meaningful risk assessment of early clinical trials. Materia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371232e0b364d853672206a9bd809a26
http://europepmc.org/articles/PMC7857342
http://europepmc.org/articles/PMC7857342
Autor:
David C. Jackson, Catherine E. Hanratty, Kian Fan Chung, John G. Matthews, Ratko Djukanovic, Maria Nunez, Robert Niven, Douglas S. Robinson, Liam G Heaney, Michelle Bourne, Catherine Borg, Clare Connolly, Mary Bellamy, Val Hudson, Gareth M. Davies, Christopher E. Brightling, Beverley Hargadon, Traceyanne Grandison, Ian M. Adcock, Sebastian L. Johnston, Rekha Chaudhuri, Geraldine Jones, James Lordan, Andrew Menzies-Gow, Adnam Azim, Dominic E. Shaw, John Busby, Ashley Woodcock, Freda Yang, Peter Bradding, Christopher Corrigan, David F. Choy, Cecile T.J. Holweg, Douglas C. Cowan, Paula McCourt, Tim Harrison, Peter H. Howarth, AH Mansur, Joel Solis, Avril Horn, Joseph R. Arron, Gabrielle Gainsborough, Sarah E Davies, Stephen J. Fowler, Roisin Stone, Timothy C. Hardman, Ian D. Pavord, Samantha Walker, Richard W. Costello, Katherine C. Smith
Publikováno v:
The Lancet. Respiratory Medicine
Heaney, L G, Busby, J, Hanratty, C E, Djukanovic, R, Woodcock, A, Walker, S M, Hardman, T C, Arron, J R, Choy, D F, Bradding, P, Brightling, C E, Chaudhuri, R, Cowan, D C, Mansur, A H, Fowler, S J, Niven, R M, Howarth, P H, Lordan, J L, Menzies-Gow, A, Harrison, T W, Robinson, D S, Holweg, C T J, Matthews, J G & Pavord, I D 2020, ' Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial ', The Lancet Respiratory Medicine, vol. 9, no. 1, pp. 57-68 . https://doi.org/10.1016/S2213-2600(20)30397-0
Investigators for the MRC Refractory Asthma Stratification Programme 2020, ' Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma : a multicentre, single-blind, parallel group, randomised controlled trial ', The Lancet. Respiratory medicine, vol. 9, no. 1, pp. 57-68 . https://doi.org/10.1016/S2213-2600(20)30397-0
Heaney, L G, Busby, J, Hanratty, C E, Djukanovic, R, Woodcock, A, Walker, S M, Hardman, T C, Arron, J R, Choy, D F, Bradding, P, Brightling, C E, Chaudhuri, R, Cowan, D C, Mansur, A H, Fowler, S J, Niven, R M, Howarth, P H, Lordan, J L, Menzies-Gow, A, Harrison, T W, Robinson, D S, Holweg, C T J, Matthews, J G & Pavord, I D 2020, ' Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial ', The Lancet Respiratory Medicine, vol. 9, no. 1, pp. 57-68 . https://doi.org/10.1016/S2213-2600(20)30397-0
Investigators for the MRC Refractory Asthma Stratification Programme 2020, ' Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma : a multicentre, single-blind, parallel group, randomised controlled trial ', The Lancet. Respiratory medicine, vol. 9, no. 1, pp. 57-68 . https://doi.org/10.1016/S2213-2600(20)30397-0
Background: Asthma treatment guidelines recommend increasing corticosteroid dose to control symptoms and reduce exacerbations. This approach is potentially flawed because symptomatic asthma can occur without corticosteroid responsive type-2 (T2)-driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ef6be32c033198e4b8e575dc156cd9
http://europepmc.org/articles/PMC7783382
http://europepmc.org/articles/PMC7783382
Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma
Autor:
James Lordan, Catherine E. Hanratty, Stephen J. Fowler, Robert Niven, Peter H. Howarth, Ian D. Pavord, Ratko Djukanovic, Douglas C. Cowan, Timothy C. Hardman, Douglas S. Robinson, Rekha Chaudhuri, David F. Choy, Joseph R. Arron, John Busby, Peter Bradding, Cecile T.J. Holweg, Christopher E. Brightling, Liam G Heaney, Samantha Walker, Andrew Menzies-Gow, Tim Harrison, AH Mansur, John G. Matthews, Ashley Woodcock
Publikováno v:
investigators for the MRC Refractory Asthma Stratification Program 2021, ' Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma ', The European respiratory journal . https://doi.org/10.1183/13993003.00768-2021
Busby, J, Matthews, J G, Chaudhuri, R, Pavord, I D, Hardman, T C, Arron, J R, Bradding, P, Brightling, C E, Choy, D F, Cowan, D C, Djukanovic, R, Hanratty, C E, Harrison, T W, Holweg, C T, Howarth, P H, Fowler, S J, Lordan, J L, Mansur, A H, Menzies-Gow, A, Niven, R M, Robinson, D S, Walker, S M, Woodcock, A & Heaney, L G 2022, ' Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma ', European Respiratory Journal, vol. 59, no. 4, 2100768 . https://doi.org/10.1183/13993003.00768-2021
Busby, J, Matthews, J G, Chaudhuri, R, Pavord, I D, Hardman, T C, Arron, J R, Bradding, P, Brightling, C E, Choy, D F, Cowan, D C, Djukanovic, R, Hanratty, C E, Harrison, T W, Holweg, C T, Howarth, P H, Fowler, S J, Lordan, J L, Mansur, A H, Menzies-Gow, A, Niven, R M, Robinson, D S, Walker, S M, Woodcock, A & Heaney, L G 2022, ' Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma ', European Respiratory Journal, vol. 59, no. 4, 2100768 . https://doi.org/10.1183/13993003.00768-2021
Background: understanding why patients with severe asthma do not follow healthcare provider (HCP) advice to adjust treatment is critical to achieving personalised disease management.Methods: we reviewed patient choice to follow HCP advice to adjust a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffac3e57c1bd41f1d84d5c166a75da1
https://eprints.soton.ac.uk/452216/
https://eprints.soton.ac.uk/452216/
Autor:
John Busby, Timothy C. Hardman, Gabrielle Gainsborough, Nazanin Zounemat Kermani, Yike Guo, Liam G Heaney, Ian M. Adcock, Ioannis Pandis, Kai Sun
Publikováno v:
Monitoring airway disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f11b324350d92d40e9e6c2286a0935de
https://doi.org/10.1183/13993003.congress-2021.oa4058
https://doi.org/10.1183/13993003.congress-2021.oa4058
Autor:
Ashley Woodcock, Liam G Heaney, Samantha Walker, James Lordan, John Busby, Peter Bradding, Douglas N. Robinson, John Matthews, Robert Niven, Rekha Chaudhuri, Cecile T.J. Holweg, Timothy C. Hardman, Adel H. Mansur, Catherine E. Hanratty, Peter H. Howarth, David F. Choy, Christopher E. Brightling, Douglas C. Cowan, Stephen J. Fowler, Tim Harrison, Ratko Djukanovic, Joseph R. Arron, Andrew Menzies-Gow, Ian D. Pavord
Publikováno v:
Epidemiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22aad1c6cdea4397fe0a4d19b62126fd
https://doi.org/10.1183/13993003.congress-2021.pa638
https://doi.org/10.1183/13993003.congress-2021.pa638