Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Timothy Burwell"'
Autor:
Gabriela M. Marchetti, Jennifer Cann, Keith W Rickert, Ruchi Gupta, Weiguang Zhao, Qing Li, Jonathan T. Boyd, Richard N. Hanna, Timothy Burwell, Herren Wu, M. Jack Borrok, William Dall'acqua, Joseph Grimsby, Emily L. Ongstad, Norman C. Peterson, Ping Tsui, Maureen Kennedy
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-10 (2019)
Communications Biology
Communications Biology
Systemic administration of bio-therapeutics can result in only a fraction of drug reaching targeted tissues, with the majority of drug being distributed to tissues irrelevant to the drug’s site of action. Targeted delivery to specific organs may al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32077e33fd53ad432f6d3fc3ce090745
http://link.springer.com/article/10.1038/s42003-019-0337-2
http://link.springer.com/article/10.1038/s42003-019-0337-2
Autor:
Michael Seungchu Yu, Timothy Burwell, Jane Connor, Norman C. Peterson, Jeongmin Hwang, Yufeng Huang, Stephen J. Weiss, Yang Li
Publikováno v:
ACS Nano
Collagen, the major structural component of nearly all mammalian tissues, undergoes extensive proteolytic remodeling during developmental states and a variety of life-threatening diseases such as cancer, myocardial infarction, and fibrosis. While deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972fabeaafa4c8b4a0a453452a726400
https://doi.org/10.1021/acsnano.7b03150
https://doi.org/10.1021/acsnano.7b03150
Autor:
Robert Lafyatis, Isabelle de-Mendez, Anthony J. Coyle, Ronald Herbst, Meggan Czapiga, Raphael Lemaire, Timothy Burwell, Jane Connor, Julie Bakken, Tracy Delaney, Hong Sun, Marlon Rebelatto, Lily Cheng
Publikováno v:
Arthritis & Rheumatology. 68:473-483
Objective Systemic sclerosis (SSc) is a fibrotic disease characterized by an obliterative vasculopathy with thrombosis and impairment of the coagulation–fibrinolysis balance. Plasminogen activator inhibitor 1 (PAI-1) is the major inhibitor of profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9f4fb9b8cba4f01b42501d30e3c318
https://doi.org/10.1002/art.39443
https://doi.org/10.1002/art.39443
Autor:
Alan M. Carruthers, Darryl A. Knight, Milena S. Espindola, David M. Habiel, Elena Miranda, Richard N. Hanna, Ethan Grant, Hao Liu, Timothy Burwell, Arthur Lewis, Cory M. Hogaboam, Lynne Murray, Fernanda Pilataxi, Ana Camelo, Ana Lucia Coelho, Matthew J. Bell, Bethany B. Moore, Lori A. Clarke
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Lung fibrosis is an unabated wound healing response characterized by the loss and aberrant function of lung epithelial cells. Herein, we report that extracellular Clusterin promoted epithelial cell apoptosis whereas intracellular Clusterin maintained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6249dbae7d6833ce5e2c2bb0c203ac15
http://europepmc.org/articles/PMC5684342
http://europepmc.org/articles/PMC5684342
Autor:
Jia Lin, Gianluca Carlesso, Nanette Mittereder, Xiang Guo, Huifang Dong, Wendy I. White, Li Yu, Michael A. Bowen, Karma Dacosta, Weiguang Zhao, Devon K. Taylor, Marie-Claude Gaudreau, Charles Brown, Ellen Kuta, Lily Cheng, Madhu Ramaswamy, Robert M. Woods, Tracy Delaney, Jie Zhu, Ronald Herbst, Changshou Gao, Anmarie Boutrin, Timothy Burwell
Publikováno v:
Science translational medicine. 10(431)
Systemic sclerosis (SSc) is a debilitating inflammatory and fibrotic disease that affects the skin and internal organs. Although the pathophysiology of SSc remains poorly characterized, mononuclear cells, mainly macrophages and T cells, have been imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0b681ed550f8f515a8ae68977f1a70
https://pubmed.ncbi.nlm.nih.gov/29626172
https://pubmed.ncbi.nlm.nih.gov/29626172
Autor:
Timothy Burwell, Fred D. Finkelman, Michael F. Gurish, K. Frank Austen, Alison A. Humbles, Tatiana G. Jones, Jenny Hallgren, Pilar Alcaide
Publikováno v:
The Journal of Immunology. 183:5251-5260
Pulmonary mast cell progenitor (MCp) numbers increase dramatically in sensitized and aerosolized Ag-challenged mice. This increase depends on CD4+ T cells, as no MCp increase occurs in the lungs of sensitized wild-type (WT) mice after mAb depletion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbd771cdf807a29d8f66006615269793
https://doi.org/10.4049/jimmunol.0901471
https://doi.org/10.4049/jimmunol.0901471
Autor:
Raphaël, Lemaire, Timothy, Burwell, Hong, Sun, Tracy, Delaney, Julie, Bakken, Lily, Cheng, Marlon C, Rebelatto, Meggan, Czapiga, Isabelle, de-Mendez, Anthony J, Coyle, Ronald, Herbst, Robert, Lafyatis, Jane, Connor
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 68(2)
Systemic sclerosis (SSc) is a fibrotic disease characterized by an obliterative vasculopathy with thrombosis and impairment of the coagulation-fibrinolysis balance. Plasminogen activator inhibitor 1 (PAI-1) is the major inhibitor of profibrinolytic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3eaa479ddbea59d333739f362452fd28
https://pubmed.ncbi.nlm.nih.gov/26414805
https://pubmed.ncbi.nlm.nih.gov/26414805
Autor:
Ethan P. Grant, Alisa Croci, Timothy Burwell, Tracy Delaney, Anthony J. Coyle, Alison A. Humbles, Michael J. Briskin, Nicole Avitahl, Jose-Carlos Gutierrez-Ramos, Dominic Picarella, Craig Gerard
Publikováno v:
The Journal of Experimental Medicine
A characteristic feature of rheumatoid arthritis is the abundance of inflammatory cells in the diseased joint. Two major components of this infiltrate are neutrophils in the synovial fluid and macrophages in the synovial tissue. These cells produce c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349d8a5d093040d3e9e5d8edf0c67167
https://doi.org/10.1084/jem.20020205
https://doi.org/10.1084/jem.20020205
Autor:
Annette Robichaud, Sophie Pegorier, Roland Kolbeck, Clare M. Lloyd, Yambasu A. Brewah, Jonas S. Erjefält, Carla P. Jones, Peter A. Kiener, Timothy Burwell, Cecilia Andersson, Jennifer Kearley, Anthony J. Coyle, Ebony Benjamin, Alison A. Humbles, Leif Bjermer
Publikováno v:
American journal of respiratory and critical care medicine. 183(7)
IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma.The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47366e2c82a968af5c1871fb2087b5f
https://pubmed.ncbi.nlm.nih.gov/21471072
https://pubmed.ncbi.nlm.nih.gov/21471072