Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Timothy Bourne"'
Autor:
Andrew Novak, David Laughton, Rebecca Lane, Emma Blackham, Jennifer Thomas, Elli Chatzopoulou, Joseph Wrigglesworth, Abdul Quddus, Saleh Ahmed, David Cousin, Lorna Duffy, Nathalie Dubois, John Unitt, Katalin Orban, Edward Browne, Michelle Ward, David Mycock, Maria Ieva, Nicholas Bland, Pascal George, Timothy Bourne, Hélène Asnagli, Louise Birch, Geraint Jones
Publikováno v:
Journal of Medicinal Chemistry. 65:16640-16650
Herein, we report the discovery of a first-in-class chemotype 2-(alkylsulfonamido)thiazol-4-yl)acetamides that act as pan-selective inhibitors of cytidine 5'-triphosphate synthetase (CTPS1/2), critical enzymes in the
Publikováno v:
Clinical Immunology and Immunopathology. 80:S23-S30
Allergic inflammatory responses are regulated by cytokines [interleukin (IL)-4, IL-5, IL-10, and IL-13] produced by CD4+ helper (Th0and Th2) cells. The activation of these T cells follows engagement of T-cell antigen receptors (TCR) by antigenic pept
Publikováno v:
Clinical and experimental immunology. 111(3)
SUMMARYCells spontaneously secreting IgG or IgM (ISC) are present at a high level in the blood of patients with systemic lupus erythematosus (SLE). By use of magnetic-bead techniques, mononuclear cells from such patients and healthy donors were fract
Autor:
Charlotte Hetzel, John D. Hayball, Nanna M. Kristensen, J. R. Lamb, Timothy Bourne, Gerard F. Hoyne
Publikováno v:
International immunology. 8(7)
In this study we demonstrate that immunization of H-2(b) mice with the allergen Der p 1 induces MHC class II restricted T cells that proliferate to residues 15-29 of Der p 1 (p15-29) and to the murine MHC class II-associated invariant chain derived p
Publikováno v:
Journal of autoimmunity. 9(1)
Blood cells spontaneously secreting IgG and IgM and the level of plasma immunoglobulins and antibodies to dsDNA, ssDNA and influenza virus haemagglutinin have been determined in families of patients with SLE, in 'normal' families and groups of 'norma
Autor:
Nanna M. Kristensen, Jonathan Robert Lamb, Charlotte Hetzel, Gerard F. Hoyne, D. C. Tsitoura, Timothy Bourne
Publikováno v:
MHC Molecules: Expression, Assembly and Function ISBN: 9781468464641
Allergic disorders such as asthma and atopic dermatitis are the result of inappropriate immune responses to environmental allergens, particularly those derived from house dust mites, pollens, animal dander, fungal spores, insect venom and certain foo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c765c2a8b871860f44bea4d8d402f62
https://doi.org/10.1007/978-1-4684-6462-7_16
https://doi.org/10.1007/978-1-4684-6462-7_16
Autor:
John L. Francis, Todd Meyer, Ali Amirkhosravi, Christopher L. Peters, Olivier Harari, Anthony Shock, Timothy Bourne, Yen-Ming Hsu, Lihe Su, Ian Wakefield, Linda C. Burkly
Publikováno v:
Blood. 116:5128-5128
Abstract 5128 Objectives: Hu5c8, a whole IgG1 anti-CD40L antibody, is known to cause thrombotic side effects in patients with Systemic Lupus Erythematosus (SLE). Anti-CD40L-mediated activation of platelets in vitro was shown to be FcγRIIa-dependent1
Autor:
Ellen Garber, Christopher Peters, Alison Maloney, Ali Amirkhosravi, David L. Hutto, Linda C. Burkly, Roland Foulkes, Neil Weir, Alastair D. G. Lawson, Frederick R. Taylor, Derek Thomas Brown, Martyn K. Robinson, Todd Meyer, Olivier A. Harari, John L. Francis, Ian Wakefield, Janine Ferrant, Timothy Bourne, Sarah Malcolm, Yen-Ming Hsu, Stevan Shaw, Lihe Su, Anthony Shock
Publikováno v:
Arthritis Research & Therapy
Introduction CD40 ligand (CD40L) blockade has demonstrated efficacy in experimental autoimmune models. However, clinical trials of hu5c8, an anti-human CD40L IgG1 antibody, in systemic lupus erythematosus (SLE) were halted due to an increased inciden