Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Timothy B. Ware"'
Autor:
Syed S. Hussain, Tuyet-Minh Tran, Timothy B. Ware, Melissa A. Luse, Christopher T. Prevost, Ashley N. Ferguson, Jennifer A. Kashatus, Ku-Lung Hsu, David F. Kashatus
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109451- (2021)
Summary: Lipid droplets (LDs) are dynamic organelles that undergo dynamic changes in response to changing cellular conditions. During nutrient depletion, LD numbers increase to protect cells against toxic fatty acids generated through autophagy and p
Externí odkaz:
https://doaj.org/article/7d1ca44d34e043e18caedbea8c3d9b61
Autor:
Harun Ozturk, Harun Cingoz, Turan Tufan, Jiekun Yang, Sara J. Adair, Krishna Seshu Tummala, Cem Kuscu, Meric Kinali, Gamze Comertpay, Sarbajeet Nagdas, Bernadette J. Goudreau, Husnu Umit Luleyap, Yagmur Bingul, Timothy B. Ware, William L. Hwang, Ku-lung Hsu, David F. Kashatus, David T. Ting, Navdeep S. Chandel, Nabeel Bardeesy, Todd W. Bauer, Mazhar Adli
Publikováno v:
Developmental cell. 57(11)
Pancreatic ductal adenocarcinoma (PDA) cells reprogram their transcriptional and metabolic programs to survive the nutrient-poor tumor microenvironment. Through in vivo CRISPR screening, we discovered islet-2 (ISL2) as a candidate tumor suppressor th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2e0e642572c6c4aa1439895ffe9fc4
https://pubmed.ncbi.nlm.nih.gov/35508175
https://pubmed.ncbi.nlm.nih.gov/35508175
Autor:
Timothy B. Ware, Ku-Lung Hsu
Publikováno v:
Curr Opin Chem Biol
Advancements in chemical proteomics and mass spectrometry lipidomics are providing new opportunities to understand lipid kinase activity, specificity, and regulation on a global cellular scale. Here, we describe recent developments in chemical biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede7511d047303f99e6a58e227ad28c3
https://europepmc.org/articles/PMC8671151/
https://europepmc.org/articles/PMC8671151/
Publikováno v:
Cannabis Cannabinoid Res
Background: Patients with rheumatoid arthritis (RA) experience joint swelling and cartilage destruction resulting in chronic pain, functional disability, and compromised joint function. Current RA treatments, including glucocorticoid receptor agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df9078eeac7ab1541161a4ce7e2d597
https://europepmc.org/articles/PMC8217598/
https://europepmc.org/articles/PMC8217598/
Autor:
Jeffrey W. Brulet, Emmanuel K. Toroitich, Adam L. Borne, Ku-Lung Hsu, Adam H. Libby, Kun Yuan, Rebecca L. McCloud, Heung Sik Hahm, Anthony M. Ciancone, Timothy B. Ware
Publikováno v:
Nature chemical biology
Covalent probes serve as valuable tools for global investigation of protein function and ligand binding capacity. Despite efforts to expand coverage of residues available for chemical proteomics (e.g. cysteine and lysine), a large fraction of the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e67754184c57e1858402514e5bc77d0
https://doi.org/10.1038/s41589-019-0404-5
https://doi.org/10.1038/s41589-019-0404-5
Publikováno v:
Biochim Biophys Acta Mol Cell Biol Lipids
The metabolic serine hydrolases hydrolyze ester, amide, or thioester bonds found in broad small molecule substrates using a conserved activated serine nucleophile. The mammalian central nervous system (CNS) express a diverse repertoire of serine hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a181faa1fbaa79d2f45f3ebaec4441
https://doi.org/10.1016/j.bbalip.2018.08.007
https://doi.org/10.1016/j.bbalip.2018.08.007
Autor:
Tuyet-Minh Tran, Ku-Lung Hsu, Christopher T. Prevost, Ashley N. Ferguson, Syed Saad Hussain, Melissa A. Luse, David F. Kashatus, Jennifer A. Kashatus, Timothy B. Ware
Publikováno v:
Cell reports
Cell Reports, Vol 36, Iss 4, Pp 109451-(2021)
Cell Reports, Vol 36, Iss 4, Pp 109451-(2021)
SUMMARY Lipid droplets (LDs) are dynamic organelles that undergo dynamic changes in response to changing cellular conditions. During nutrient depletion, LD numbers increase to protect cells against toxic fatty acids generated through autophagy and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b6c784578bf34ffa6c8653e718d753
https://doi.org/10.1016/j.celrep.2021.109451
https://doi.org/10.1016/j.celrep.2021.109451
Autor:
Timothy B. Ware, Andreas Gahlmann, Thurl E. Harris, Kwon-Sik Park, Mingxing Zhang, Mitchell E. Granade, Kee-Beom Kim, Ku-Lung Hsu, Caroline E. Franks
Publikováno v:
Nature chemical biology
C1 domains are lipid-binding modules that regulate membrane activation of kinases, nucleotide exchange factors and other C1-containing proteins to trigger signal transduction. Despite annotation of typical C1 domains as diacylglycerol (DAG) and phorb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274bcd64d87fecb54691e3b5f607dfbc
https://pubmed.ncbi.nlm.nih.gov/31932721
https://pubmed.ncbi.nlm.nih.gov/31932721
Publikováno v:
Cell Chem Biol
Here, we apply quantitative chemical proteomics and untargeted lipidomics to assign a polyunsaturated fatty acid (PUFA)-specific triacylglycerol (TAG) lipase activity for diacylglycerol lipase-beta (DAGLβ) in macrophages. We demonstrate that DAGLβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d0b8ffaf81d6d4ded51743dacabeaa
https://doi.org/10.2139/ssrn.3464032
https://doi.org/10.2139/ssrn.3464032
Publikováno v:
Methods Enzymol
Lipids exert key structural, metabolic, and signaling functions in cells. Lipid diversity found in cells and tissues is regulated principally by metabolic enzymes whose activity is modulated post-translationally to shape head group and fatty acyl com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f40c21b366b13d473b320fb10238f1e
https://doi.org/10.1016/bs.mie.2019.06.027
https://doi.org/10.1016/bs.mie.2019.06.027