Výsledky vyhledávání - "Timothy B. Parks"

Expanding the Therapeutic Potential of the Iron Chelator Deferasirox in the Development of Aqueous Stable Ti(IV) Anticancer Complexes

Autor: Yamixa Delgado, Timothy B. Parks, Angel L. Vazquez-Maldonado, Lenny J. Negrón, Arthur D. Tinoco, Josué A. Benjamín-Rivera, Sergio A. Loza-Rosas, Charlene Munet-Colón, Alexandra M. Vázquez-Salgado, Kennett I. Rivero

Publikováno v: Inorganic Chemistry. 56:7788-7802

The recent X-ray structure of titanium(IV)-bound human serum transferrin (STf) exhibiting citrate as a synergistic anion reveals a difference in Ti(IV) coordination versus iron(III), the metal endogenously delivered by the protein to cells. This find

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8be488261bc9375018801d193c2ec8
https://doi.org/10.1021/acs.inorgchem.7b00542

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The unusual synergism of transferrin and citrate in the regulation of Ti(IV) speciation, transport, and toxicity

Autor: Manoj Saxena, Arthur D. Tinoco, Shweta Sharma, Ernesto P. Quiñones González, Nicholas Noinaj, Yamixa Delgado, Steven E. Conklin, Timothy B. Parks, Sergio A. Loza-Rosas, Nicole Zambrana

Human serum transferrin (sTf) is a protein that mediates the transport of iron from blood to cells. Assisted by the synergistic anion carbonate, sTf transports Fe(III) by binding the metal ion in a closed conformation. Previous studies suggest sTf's

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6279ff61ffba2b7bff3edf256d76d263
https://europepmc.org/articles/PMC4865248/

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Applying the Fe(III) binding property of a chemical transferrin mimetic to Ti(IV) anticancer drug design

Autor: Yahaira M. Cruz, Timothy B. Parks, Arthur D. Tinoco

Publikováno v: Inorganic chemistry. 53(3)

As an endogenous serum protein binder of Ti(IV), transferrin (Tf) serves as an excellent vehicle to stabilize the hydrolysis prone metal ion and successfully transport it into cells. This transporting role is thought to be central to Ti(IV)'s antican

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fe92c1023c951647faf1f83dba0174
https://pubmed.ncbi.nlm.nih.gov/24422475

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Abstract 3105A: Titanium(IV) regulation by serum transferrin and citrate sheds new insight into the use of chemical transferrin mimetics for Ti(IV) anticancer drug development

Autor: Annelis Sanchez, Yamixa Delgado, Lenny M. Negron, Sergio A. Loza-Rosas, Arthur D. Tinoco, Timothy B. Parks, Shweta Sharma, Alexandra Vazquez, Manoj Saxena, Kennett I. Rivero, Nicole Zambrana

Publikováno v: Cancer Research. 76:3105A-3105A

A recently resolved structure of Ti(IV) bound human serum transferrin (sTf) and cell viability studies reveal that the small molecule citrate and the iron(III) transport protein sTf work together to maintain Ti(IV) in a nontoxic speciation in the bod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3580124b1ba68a9efc2b91b4e791452
https://doi.org/10.1158/1538-7445.am2016-3105a

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